Oleanolic Acid Powder

Asam Oleanolic kang telung triterpenoids pentacyclic diisolasi saka Gentianaceae tetanduran saka Swertia mileensis kabèh suket utawa privet woh, karo awak free lan glikosida ing akeh tetanduran. Asam Oleanolic wis sawetara saka sudhut ing tetanduran, lan isi rata-rata punika 0,2% - 2%. Cucurbitaceae isi dhuwur 1,5% ~ hunchback ngisor 2%, privet isi woh 0,6% ~ 0.7% .Oleanolic asam jenis senyawa triterpenoid pentacyclic diisolasi saka woh saka genus Asteraceae, Syzygium sylvestris, utawa Ligustrum lucidum. Iku adjuvant penyakit ati lan klinik digunakake kanggo infèksi babagan pengobatan. Leukemia jaundice hepatitis nduweni efek ketok ing ngurangi aminotransferase alanine lan asam yellowing.Oolic punika triterpenoids pentacyclic diisolasi saka woh saka swertia chinensis utawa fructus ligustris saka tanduran Gentianaceae. Asam Oleanolic iki digunakake ana ing tanduran, karo isi umum 0.2% ~ 2% [1]. Isi ngisor Calabash ana 1,5% ~ 2%, lan isi saka woh ligustris fructus ana 0,6% ~ 0.7%. Asam Oleanolic putih kristal acicular (alkohol), ora ana ambuné lan tasteless. Boten stabil kanggo asam lan basa. Titik 308 ~ 310 ℃ leleh, [alpha] 20 d + 73.3 ° (c = 0,15, chloroform, larut ing banyu, telat ing metanol, etanol, etil ether, aseton lan asam chloroform.Oleanolic punika triterpenoid alami, sakdawané ing pangan lan medicinal tetanduran, related kanggo asam betulinic. bisa ditemokake ing Phytolacca americana (American pokeweed), lan Syzygium spp, papak, etc. iku non-beracun, hepatoprotective, lan pameran antitumor lan antiviral.
asam Oleanolic ana ketemu ngetokne kegiatan anti-HIV kuwat, asam betulinic senyawa sing gegandhengan iki digunakake kanggo nggawe tamba mateng inhibitor komersial pisanan. Bab iki pisanan sinau lan diisolasi saka sawetara tetanduran, kalebu Rosa woodsii (godhong), Prosopis glandulosa (godhong lan twigs), Phordendron juniperinum (kabèh tetanduran), Syzygium claviflorum (godhong), Hyptis Capitata (tetanduran kabèh), lan Ternstromia gymnanthera (sisih pangeboman). spesies Syzygium Other kalebu java apple (Syzygium samarangense) lan wungu apple s ngemot iku.

Product Name: Oleanolic asam  98 %

Keterangan: 98% dening HPLC

Botanic Source: Olea Europea Extract

Jeneng kimia: (3β) -3-Hydroxyolean-12-en-28-oic asam

CAS No: 508-02-1

Part Digunakna: Leaf

Warna: bubuk putih karo ambu ora enak karakteristik lan rasa

Status GMO: GMO Free

Packing: ing 25kgs drum serat

Storage: Tansah wadhah unopened ing kelangan, garing Panggonan, Tansah adoh saka cahya kuwat

Beting urip: 24 sasi saka tanggal produksi

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

fungsi:

Asam 1.Oleanolic iku non-beracun, antitumor, lan hepatoprotective, uga mameraken antiviral.
Asam 2.Oleanolic ketemu ngetokne kegiatan anti-HIV kuwat.
Asam 3.Oleanolic iku pelindung utama saka sel marang oksidatif lan kaku elektrofil.
Asam 4.Oleanolic wis gedhe efek ing trating virus hepatitis, hepatitis icteric leukemia lan hepatitis kronis.
aplikasi:
1. Terapan ing lapangan pangan, iku bisa tumindak minangka bahan baku teh kanggo ngurangi phlegm;
2. Terapan ing lapangan pharmaceutical, dadi tamba anti-kanker anyar karo beracun kurang;
3. Terapan ing lapangan kosmetik, iku bisa invigorate getih circulation lan mbusak wedang.