Oleanolic Acid Powder

L' acide oléanolique qui est un trois triterpénoïdes pentacycliques à partir de plantes Gentianaceae de Swertia mileensis l'herbe fruits entiers ou troène, avec un corps libre et glycosides dans de nombreuses plantes. L' acide oléanolique présente une large gamme de plantes, et la teneur moyenne est de 0,2% - 2%. Cucurbitaceae haute teneur est de 1,5% ~ fond bossu 2%, le troène teneur en fruits de 0,6% ~ 0,7% d' acide .Oleanolic est un type de composé pentacyclique triterpénique isolé à partir du fruit du genre Asteraceae, Syzygium sylvestris, ou Ligustrum lucidum. Il est un adjuvant de la maladie du foie et cliniquement utilisé pour l' infection thérapeutique. L' hépatite aiguë jaunisse a des effets évidents sur la réduction de l' alanine aminotransférase et de l' acide yellowing.Oolic est un triterpénoïdes pentacycliques isolé du fruit de swertia chinensis ou fructus ligustris de l'usine de Gentianaceae. L' acide oléanolique est largement présent dans les plantes, d'une teneur en général de 0,2% ~ 2% [1]. Le contenu de fond de calebasse était de 1,5% ~ 2%, et la teneur en fruits de ligustris fructus était de 0,6% ~ 0,7%. L' acide oléanolique est blanc cristal aciculaire (éthanol), inodore et insipide. Instable aux acides et aux bases. Point de fusion de 308 ~ 310 ℃, [alpha] 20 D + 73,3 ° (c = 0,15, chloroforme, insoluble dans l' eau, soluble dans le méthanol, l' éthanol, l' éther éthylique, l' acétone et l' acide chloroform.Oleanolic est un triterpénoïde d' origine naturelle, largement distribuée dans les aliments et les plantes médicinales, liées à l' acide bétulinique. Il se trouve dans Phytolacca americana (pokeweed américain), et Syzygium spp, l' ail, etc. Il est relativement non toxique, hépato et expositions antitumorale et propriétés antivirales. L'
acide oléanolique était JUGÉE présentent une forte activité anti-VIH, le composé apparenté acide bétulinique a été utilisé pour créer le premier médicament inhibiteur de maturation commerciale. Il a d' abord étudié et isolé de plusieurs plantes, dont Rosa woodsii (feuilles), Prosopis glandulosa (feuilles et brindilles), Phordendron juniperinum (plante entière), Syzygium claviflorum (feuilles), Hyptis capitata (plante entière), et Ternstromia gymnanthera (partie aérienne). d' autres espèces , y compris Syzygium pomme java (jamalac) et pomme rose s contiennent.

Nom du produit: Acide oléanolique  98 %

Caractéristique: 98% par HPLC

Botanique Source: Olea europaea Extrait

Nom chimique: (3β) -3-Hydroxyolean-12-en-28-oïque

CAS No: 508-02-1

Partie utilisée: Feuille

Couleur: Poudre blanche avec odeur et le goût caractéristique

OGM Statut: Sans OGM

Emballage: 25kgs dans des fûts en carton

Stockage: Conserver le récipient non ouvert dans un endroit frais et sec, Tenir à l'écart de la lumière forte

Durée de conservation: 24 mois à compter de la date de production

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Une fonction:

L' acide 1.Oleanolic est relativement non toxique, antitumorale et hépatoprotecteur, ainsi que présentant des propriétés antivirales.
L' acide 2.Oleanolic a été trouvé à présenter une forte activité anti-VIH.
Acide 3.Oleanolic est un protecteur majeur des cellules contre le stress oxydatif et l' électrophile.
L' acide 4.Oleanolic a un grand effet sur l' hépatite virale trant, l' hépatite aiguë et l' hépatite chronique icteric.
Application:
1. appliquée dans le domaine alimentaire, il peut agit comme matières premières de thé pour réduire le flegme;
2. appliquée dans le domaine pharmaceutique, il devient un nouveau médicament anti-cancer avec une faible toxicité;
3. appliquée dans le domaine cosmétique, il peut revigorer la circulation sanguine et éliminer les boissons.