Oleanolic Acid Powder

Oleanolic sauerem dat ass eng dräi pentacyclic triterpenoids isoléiert aus Gentianaceae Planzen vun Swertia mileensis de ganzen ausgerëtscht oder privet Uebst, mat engem gratis Kierper an Glycosiden ville Planzen. Oleanolic Seier huet eng breet Palette vun Planzen, an der Moyenne Inhalt ass 0,2% - 2%. Cucurbitaceae héich Inhalt ass 1,5% ~ hunchback ënnen 2%, privet Uebst Inhalt vun 0.6% ~ 0,7% .Oleanolic sauerem ass eng Zort pentacyclic triterpenoid Facettenaen aus dem Uebst vun der Gattung isoléiert Asteraceae, Syzygium sylvestris, oder Ligustrum lucidum. Et ass eng adjuvant Liewer Krankheet a klinesch fir therapeutesch Krankheet benotzt. Fouss dohinner jaundice hepatitis huet kloer Effekter op reduzéieren alanine aminotransferase an yellowing.Oolic sauerem ass eng pentacyclic triterpenoids aus dem Uebst vun swertia chinensis oder fructus isoléiert ligustris vum gentianaceae Planz. Oleanolic sauerem ass an Planzen, mat engem allgemenge Inhalt vun 0,2% ~ 2% [1] dicht fonnt. Den Inhalt vun ënnen calabash war 1,5% ~ 2%, an den Inhalt vun Uebst vun fructus ligustris war 0.6% ~ 0,7%. Oleanolic sauerem ass wäiss acicular Kristallsglas produzéiert (Ethanol), odorless an tasteless. Onbestänneg ze Saieren a Base. Melting Punkt vun 308 ~ 310 ℃, [Alpha] 20 d + 73.3 ° (c = 0,15, chloroform, insoluble am Waasser, soluble zu methanol, Ethanol, ethyl ETHER, acetone an chloroform.Oleanolic sauerem ass, eng natierlech geschitt triterpenoid dicht verdeelt an Iessen a Medikamenter Planzen, bis betulinic sauerem dinn. Et zu Phytolacca United (American pokeweed) fonnt ginn, an Syzygium niwweleg, Knuewelek, etc. Et ass relativ net-gëfteg, hepatoprotective, a geet antitumor an antiviral Eegeschafte.
Oleanolic sauerem war fonnt staark anti-HIV Aktivitéit, déi am Zesummenhang Facettenaen betulinic sauerem benotzt gouf zu weise déi éischt kommerziell maturation inhibitor Drogenofhängeger ze schafen. Et war éischter aus verschiddene Planzen, dorënner Rosa woodsii (Blieder), Prosopis glandulosa (Blieder an twigs) studéiert an isoléiert, Phordendron juniperinum (ganz Planz), Syzygium claviflorum (Blieder), Hyptis capitata (ganz Planz), an Ternstromia gymnanthera (Loftopklärung Deel). Aner Syzygium Arten dorënner nei Adress Apple (Syzygium samarangense) an opgestan Apple den enthalen ass.

Produit Numm: Oleanolic Saier  98 %

Spezifizéierung: 98% vun HPLC

Bamschoul Source: Olea EUROPÄE Extrait

Chemeschen Numm: (3β) -3-Hydroxyolean-12-en-28-oic sauerem

Déifsten Ënnerbewosstsinn Nee: 508-02-1

Deel Occasiounsautoen: Leaf

Faarf: White Pudder mat charakteristesche Geroch a Geschmaach

GMO Status: GMO Free

Uërtschaft: an 25kgs Léngen Drums

Stockage: Verfollegt Container unopened zu cool, dréchen Plaz halt ewech staark Liichtjoer

Regal Life: 24 Méint aus Datum vun Produktioun

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Funktioun:

1.Oleanolic sauerem ass relativ Net-gëfteg, antitumor, an hepatoprotective, souwéi suer- antiviral Eegeschafte.
Staark anti-HIV Aktivitéit ze weise war 2.Oleanolic sauerem fonnt.
3.Oleanolic sauerem ass eng grouss Protecteur vun Zellen géint oxidative an electrophile Stress.
4.Oleanolic Seier huet super Effet op zent Virus hepatitis, Fouss dohinner icteric hepatitis a chronescher hepatitis.
Applikatioun:
1. sämtleche Liewensmëttel Terrain, kënne si geschlossen als Matière première vun Téi phlegm ze reduzéieren;
2. sämtleche pharmazeuteschen Terrain, gëtt et eng nei Anti-Kriibs Drogenofhängeger mat niddereg gëfteg;
3. sämtleche kosmetesch Terrain, kann et Blutt Circulatioun an ewechzehuelen Gedrénks verzauberen.