Oleanolic Acid Powder

Swertia arasında Gentianaceae bitkilerinden izole edilmiş bir üç pentasiklik triterpenoidlerin olan oleanolik asit birçok bitkilerdeki serbest gövde ve glikozitler ile bütün ot veya Kurtbağrı meyve mileensis. Oleanolik asit bitkilerde geniş bir yelpazesine sahiptir ve ortalama içeriği% 0.2 -% 2. Kabakgiller içeriği yüksek% 1.5 ~ kambur taban% 2,% 0,6 ~% 0.7 .Oleanolic asit Kurtbağrı meyve oranı, genus Asteraceae, Syzygium sylvestris veya Ligustrum lucidum ve meyve izole pentasiklik triterpenoid bileşiği, bir tür olmasıdır. Bir karaciğer hastalığı yardımcı madde ve klinik olarak tedavi enfeksiyonu için kullanılır. Akut sarılık hepatit alanin aminotransferaz azaltılması ve yellowing.Oolic asit Swertia chinensis veya Fructus meyvesinden izole edilen bir pentasiklik triterpenoidlerin gentianaceae bitkiden ligustris olduğu ilgili belirgin etkileri vardır. Oleanolik asit yaygın olarak% 0.2 ~% 2 [1] genel içerikli bitkilerde bulunur. Sukabağı alt içeriği ~% 2,% 1.5 idi, ve Fructus ligustris meyve içeriği ~% 0.7% 0.6 idi. Oleanolik asit, beyaz iğne şekilli kristal (etanol), kokusuz ve tatsızdır. Asitler ve bazlar Kararsız. ~ 310 308 Erime noktası ℃, [a] 20D + 73.3 ° (c = 0.15, kloroform, su içinde çözünmeyen, metanol içinde çözünür, etanol, etil, aseton ve chloroform.Oleanolic asit doğal olarak oluşan bir triterpenoid, yaygın olarak dağıtılan eter Bu gibi Phytolacca americana (Amerikan pokeweed) ve Syzygium spp, sarımsak, bulunabilir betulinik asit ile ilgili yiyecek ve tıbbi bitkilerde. Bu karaciğer koruyucu, nispeten toksik olmayan ve sergiler anti-tümör ve antiviral özellikleri.
Oleanolik asit oldu güçlü bir anti-HIV aktivitesi sergiledikleri bulunmuştur, ilgili bileşik betulinik asit elde edildi. ilk ticari olgunlaşma inhibitörü ilacı oluşturmak için kullanılan ilk Rosa woodsii (yaprak), Prosopis glandulosa (yaprak ve sürgünden) dahil olmak üzere çeşitli bitkilerden incelenmiştir ve izole edilmiş, Phordendron juniperinum (tüm bitki), Syzygium claviflorum (yaprak), Hyptis capitata (tüm bitki) ve Ternstromia gymnanthera (anten bölümü). java elma dahil olmak üzere diğer Syzygium türleri (Syzygium samarangense) ve elma gül s bunu.

Ürün Adı: Oleanol Asit  98 %

Özellikler: HPLC ile% 98

Botanik Kaynak: Olea Europea Özü

Kimyasal adı: (3β) -3-Hydroxyolean-12-en-28-oik asit

CAS No: 508-02-1

Bölüm Kullanılan: Yaprak

Renk: karakteristik koku ve tadı ile beyaz toz

GDO Durum: GMO Free

Ambalaj: 25kgs fiber fıçılar içerisinde

Depolama: serin, kuru bir yerde açılmamış saklayınız güçlü ışıktan uzak tutun

Raf Ömrü: Üretim tarihinden itibaren 24 ay

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

İşlev:

1.Oleanolic asit nispeten toksik olmayan, anti-tümör ve karaciğer koruyucu ve aynı zamanda antiviral özellikleri ortaya koymanın bir.
2.Oleanolic asit güçlü bir anti-HIV aktivitesi sergiledikleri bulunmuştur.
3.Oleanolic asit oksidatif ve elektrofil strese karşı hücrelerinin ana koruyucudur.
4.Oleanolic asit virüs hepatit, akut sarılık hepatit, kronik hepatit ve süzücü üzerinde büyük bir etkisi vardır.
Uygulama:
gıda alanında 1. Uygulama, bu balgam azaltmak için çay hammadde olarak can işlev görür;
Farmasötik alanda 2. Uygulama, düşük toksik olan yeni bir anti-kanser ilaç haline gelir
Kozmetik alanında 3. Uygulamalı, kan dolaşımını canlandırmak ve içecek kaldırabilirsiniz.