Oleanolic Acid Powder

Oleanolicʻakika a mea he ekolu pentacyclic triterpenoids kaʻawale mai Gentianaceae mea kanu o Swertia mileensis ka a pau mauʻu a privet ka hua, a me ka noa kino a me glycosides i loko o na mea kanu. Oleanolicʻakika i ke akea huahelu i ka mea kanu, a me ka awelika maʻiʻo mea 0.2% - 2%. Cucurbitaceae kiʻekiʻe maʻiʻo mea 1.5% ~ kuapuu lalo 2%, privet hua maʻiʻo o 0,6% ~ 0,7% .Oleanolicʻakika mea heʻano o pentacyclic triterpenoid hui kaʻawale mai o ka hua o ka genus Asteraceae, Syzygium sylvestris, a Ligustrum lucidum. He He ake maʻi adjuvant a clinically hoʻohana no ka pākōlea maʻiʻaʻai. Huʻi jaundice hepatitis i maopopo 'ole ma hoemi alanine aminotransferase a yellowing.Oolicʻakika mea he pentacyclic triterpenoids kaʻawale mai o ka hua o ka swertia chinensis a fructus ligustris mai ka gentianaceae loa. Oleanolicʻakika ua hoʻomano i loaʻa i loko o mea kanu, a me ka nui ka maʻiʻo o ka 0.2% ~ 2% [1]. Ka maʻiʻo o lalo o ka ipu ua 1.5% ~ 2%, a me ka maʻiʻo o ka hua o ka fructus ligustris ua 0,6% ~ 0,7%. Oleanolicʻakika mea keʻokeʻo acicular aniani (ethanol), odorless a me tasteless. He hu wale me nāʻakika a me nā kumu. Ke Kēhaupaʻa wahi o ka 308 ~ 310 ℃, [Alpha] 20 b + 73.3 ° (c = 0,15, chloroform, insoluble i loko o ka wai, wailana ma ka metanola, ethanol,'eto me Etera, a me acetone chloroform.Oleanolicʻakika ua he maoli ai i hana triterpenoid, hoʻomano haawi ma ka ai, a me ka lāʻau lapaʻau mea kanu, e pili pū ana i ka betulinicʻakika. ua hiki ke loaʻa i loko o Phytolacca americana ( 'Amelika pokeweed), a me Syzygium spp, kālika, etc. he kŘpa ole-ʻawahia, hepatoprotective, a me ka ho'āʻoʻia antitumor a me antiviral waiwai.
Oleanolicʻakika ua ike mai la laua i ka ho'āʻo ikaika Anati-HIV haʻawina, na nā hui betulinicʻakika ua hoʻohana 'ia e hana i ka mua kalepa maturation inhibitor lāʻau. It ua aʻo mua, a kaʻawale, mai kekahi mau mea kanu, a me Rosa woodsii (lau), Prosopis glandulosa (lau a me twigs), Phordendron juniperinum (a pau kanu), Syzygium claviflorum (lau), Hyptis capitata (a pau kanu), a me Ternstromia gymnanthera (Honolulu hapa). Other Syzygium ioeo me Iawa kii onohi (Syzygium samarangense), a ku ae la kii onohi mau māmala'ōlelo i loko o laila.

Product Name: Oleanolicʻakika  98 %

Hoakaka: 98% ma ka HPLC

Botanic Source: Olea Europea extract

Nine Name: (3β) -3-Hydroxyolean-12-em-28-oicʻakika

CAS No: 508-02-1

Part Used: lau

Waihoʻoluʻu: White ka pauka me ka ano ala a me kaʻaiʻana

GMO you: GMO Free

Hāʻawe: i 25kgs puluniu pahu

Waho pūnaewele: E ipu unopened i ka me, maloo wahi, E aku mai ka ikaika kukui

Holopapa Life: 24 mahina mai ka la aku o ka? Iecaianoaaiiuo

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Launch:

1.Oleanolicʻakika, kŘpa ole-ʻawahia, antitumor, a me hepatoprotective, e like me hoike antiviral waiwai.
2.Oleanolicʻakika Ua loaʻa e ho'āʻo ikaika Anati-HIV hope.
3.Oleanolicʻakika mea he nui pale o ke keena e ku e oxidative a me electrophile stress.
4.Oleanolicʻakika mea nui ia ma luna o trating mea hoʻomaʻi hepatitis, huʻi icteric hepatitis a me ka maʻi hepatitis.
palapala noi:
1. haʻapili i kaʻai ke kahua, ka mea e hiki hana like maka mea o ka kī, e ho'ēmi i phlegm;
2. haʻapili i ka mea lāʻau lapaʻau ke kahua, ka mea lilo i ka hou Anati-Ka maʻi 'aʻai lāʻau me ka haʻahaʻaʻawahia;
3. haʻapili i ka mea hoʻonani ke kahua, ka mea hiki ke hoʻoulu hou ke koko holo, a wehe i ka mea inu.