Oleanolic Acid Powder

Acidul oleanolic , care este o perioadă de trei triterpenoide pentaciclice izolate din plante Gentianaceae de Swertia mileensis întreaga iarbă sau privet fruct, cu un corp liber și glicozide în multe plante. Acidul oleanolic are o gamă largă în plante, iar conținutul mediu este de 0,2% - 2%. Conținut ridicat de cucurbitacee este de 1,5% ~ cocoșată fund 2%, conținut de fructe privet de 0,6% ~ 0,7% acid .Oleanolic este un fel de compus triterpenice pentaciclic izolat din fructul din genul Asteraceae, Syzygium sylvestris sau Ligustrum lucidum. Este un adjuvant boala de ficat si utilizat clinic pentru infecția terapeutică. Hepatită acută icter are efecte evidente asupra reducerii alaninaminotransferaza și acid yellowing.Oolic este o triterpenoide pentaciclice izolate din fructul chinensis Swertia sau fructus ligustris din planta Gentianaceae. Acidul oleanolic este larg găsit în plante, cu un conținut de 0,2% generală ~ 2% [1]. Conținutul de jos a calabash a fost de 1,5% ~ 2%, iar conținutul de fructe al ligustris fructus a fost de 0,6% ~ 0,7%. Acid oleanolic este cristal alb acicular (etanol), inodor și fără gust. Instabil la acizi și baze. Punct de 308 ~ 310 ℃ de topire, [alfa] 20 d + 73,3 ° (c = 0,15, cloroform, insolubil în apă, solubil în metanol, etanol, eter etilic, acetonă și acid chloroform.Oleanolic este un triterpenoid în mod natural, distribuite pe scară largă în plantele alimentare și medicinale, legate de acidul betulinic. poate fi găsit în Phytolacca americana (pokeweed american) și Syzygium spp, usturoi, etc. este relativ non-toxic, hepatoprotector, și prezintă o antitumorală și proprietăți antivirale.
acidul oleanolic a fost a constatat că prezintă o puternică activitate anti-HIV, acidul betulinic compus înrudit a fost utilizat pentru a crea primul medicament inhibitor al maturizării comercial. a fost studiată mai întâi și izolat din mai multe plante, inclusiv Rosa woodsii (frunze), Prosopis glandulosa (frunze și ramuri), Phordendron juniperinum (planta întreagă), syzygium claviflorum (frunze), Hyptis capitata (planta întreagă) și Ternstromia gymnanthera (partea aeriană). Alte specii syzygium inclusiv java măr (Syzygium samarangense) și a crescut de mere s - l conțin.

Nume produs: Acid oleanolic  98 %

Specificații: 98% prin HPLC

Botanic Sursa: Olea Europea Extras

Denumire chimică: (3β) -3-Hydroxyolean-12-en-28-oic

CAS: 508-02-1

Partea Folosit: Frunza

Culoare: Pulbere albă, cu miros caracteristic și gust

Statut OMG: OMG

Ambalaj: în butoaie de fibre 25kgs

Depozitare: A se păstra recipientul sigilat în loc rece, uscat, se ține la distanță de lumină puternică

Valabilitate: 24 luni de la data productiei

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Funcţie:

Acidul 1.Oleanolic este relativ non-toxic, antitumoral și hepatoprotectoare, precum și prezintă proprietăți antivirale.
Acidul 2.Oleanolic a fost descoperit că prezintă o puternică activitate anti-HIV.
Acid 3.Oleanolic este un protector major al celulelor împotriva stresului oxidativ și electrofil.
Acid 4.Oleanolic are mare efect asupra trating virusului hepatitei, hepatita acuta icterica si hepatita cronică.
Aplicație:
1. Aplicate în domeniul alimentar, se poate comporta ca materii prime de ceai pentru a reduce flegma;
2. Aplicate în domeniul farmaceutic, acesta devine un nou medicament anti-cancer , cu toxicitate redusă;
3. Aplicate în domeniul cosmetic, poate revigora circulația sângelui și elimina băutură.