Oleanolic Acid Powder

Ácido oleanólico, que é um três triterpenóides pentacíclicos isolados a partir de plantas Gentianaceae de Swertia mileensis toda a grama ou ligustro fruta, com um corpo livre e glicósidos em muitas plantas. Ácido oleanólico tem uma vasta gama de plantas, e o teor médio é de 0,2% - 2%. Cucurbitaceae alto teor é de 1,5% ~ corcunda inferior a 2%, conteúdo de fruta ligustro de 0,6% ~ 0,7% de ácido .Oleanolic é um tipo de composto triterpenóides pentacíclicos isolado a partir do fruto do género Asteraceae, Syzygium sylvestris, ou Ligustrum lucidum. É um adjuvante e doença hepática clinicamente utilizada para a infecção terapêutico. Aguda icterícia hepatite tem efeitos óbvios sobre a redução da aminotransferase de alanina e ácido yellowing.Oolic é um triterpenóides pentacíclicos isolados a partir do fruto de Swertia chinensis ou fructus ligustris a partir da planta gentianaceae. Ácido oleanólico é amplamente encontrado em plantas, com um teor geral de 0,2% a 2% ~ [1]. O conteúdo de fundo da cabaça foi de 1,5% ~ de 2%, e o conteúdo de fruta de ligustris fructus foi de 0,6% ~ 0,7%. Ácido oleanólico é cristal acicular branco (etanol), inodoro e insípido. Instável aos ácidos e bases. Ponto de derretimento 308 ~ 310 ℃, [alfa] 20 d + 73,3 ° (c = 0,15, clorofórmio, insolúvel em água, solúvel em metanol, etanol, éter etílico, acetona e ácido chloroform.Oleanolic é um triterpenoide que ocorre naturalmente, amplamente distribuído em plantas alimentares e medicinais, relacionadas com ácido betulinico. Ela pode ser encontrada em Phytolacca americana (pokeweed americana), e Syzygium spp, alho, etc. é relativamente não-tóxico, hepatoprotector, e exposições antitumoral e propriedades antivirais.
ácido oleanólico foi verificou exibirem forte actividade anti-HIV, o ácido betulínico composto relacionado foi utilizado para criar o primeiro medicamento inibidor de maturação comercial. foi estudado em primeiro lugar e isolado a partir de várias plantas, incluindo Rosa woodsii (folhas), Prosopis glandulosa (folhas e galhos), Phordendron juniperinum (planta inteira), Syzygium claviflorum (folhas), Hyptis capitata (planta inteira), e Ternstromia gymnanthera (parte aérea). Outras espécies Syzygium incluindo maçã java (Syzygium samarangense) e jambo s contê-lo.

Nome do produto: Ácido Oleanolic  98 %

Especificação: 98% por HPLC

Botânico Fonte: Extrato de Olea Europea

Nome químico: (3β) -3-Hydroxyolean-12-en-28-óico

CAS: 508-02-1

Parte utilizada: Folha

Cor: pó branco com odor característico e sabor

Estado OGM: GMO Free

Embalagem: em tambores de fibra 25kgs

Armazenamento: Mantenha o recipiente fechado em local fresco e seco, manter longe da luz forte

Validade: 24 meses a partir da data de produção

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Função:

Ácido 1.Oleanolic é relativamente não-tóxica, anti-tumoral, e hepatoprotector, bem como exibindo propriedades antivirais.
Ácido 2.Oleanolic exibia uma forte actividade anti-HIV.
Ácido 3.Oleanolic é um importante protetor de células contra o stress oxidativo e electrófilo.
Ácido 4.Oleanolic tem um grande efeito sobre trating vírus da hepatite, hepatite ictérica aguda e hepatite crónica.
Aplicação:
1. Aplicada na área de alimentos, que pode funciona como matérias-primas de chá para reduzir o catarro;
2. Aplicada no campo farmacêutico, torna-se um novo fármaco anti-cancro com baixa toxicidade;
3. Aplicada no campo cosmético, pode fortalecer a circulação sanguínea e remover bebida.