Oleanolic Acid Powder

Aigéad oleanolic is trí triterpenoids pentacyclic scoite amach ó phlandaí Gentianaceae na Swertia mileensis an féar nó pribhéad torthaí ar fad, le comhlacht saor in aisce agus gliocóisídí i go leor plandaí. Tá aigéad oleanolic réimse leathan i bplandaí, agus is é an t-ábhar ar an meán 0.2% - 2%. Is ábhar Cucurbitaceae ard 1.5% ~ Tá bun hunchback 2%, cion torthaí pribhéad de 0.6% ~ 0.7% .Oleanolic aigéad ar chineál an cumaisc triterpenoid pentacyclic scoite amach ón torthaí den ghéineas Asteraceae, Syzygium sylvestris, nó Ligustrum lucidum. Is aidiúvach galar ae agus go cliniciúil a úsáidtear le haghaidh ionfhabhtú teiripeacha. Tá Géar jaundice heipitíteas éifeachtaí soiléir ar laghdú aminotransferase alanine agus tá aigéad yellowing.Oolic a triterpenoids pentacyclic scoite amach ó thoradh chinensis Swertia nó samhail ar ár dtáirgí ligustris ó na plandaí gentianaceae. Tá aigéad oleanolic le fáil go forleathan i ngléasraí, a bhfuil cion ginearálta 0.2% ~ 2% [1]. Bhí ábhar na bun an calabash 1.5% ~ 2%, agus ba é an t-ábhar na torthaí de ligustris samhail ar ár dtáirgí 0.6% ~ 0.7%. Is aigéad oleanolic criostail bán acicular (eatánól), bholadh agus gan bhlas. Éagobhsaí le aigéid agus bunanna. Leáphointe pointe 308 ~ 310 ℃, [alfa] 20 d + 73.3 ° (c = 0.15, Clóraform, go héasca in uisce, intuaslagtha i meatánól, eatánól, eitile éitear, haicéatón agus aigéad chloroform.Oleanolic tá triterpenoid a tharlaíonn go nádúrtha, a dháileadh go forleathan i mbia agus míochaine plandaí, a bhaineann le aigéad betulinic. Is féidir é a fháil i Phytolacca Americana (pokeweed Mheiriceá), agus Syzygium spp, gairleog, etc tá sé sách neamh-tocsaineach, hepatoprotective, agus taispeántais antitumor agus airíonna antiviral.
ba aigéad oleanolic fuair a chur ar taispeáint láidir frith-VEID, baineadh úsáid as an aigéad betulinic cumaisc gaolmhar a chruthú ar an chéad drugaí aibithe inhibitor tráchtála. bhí sé staidéar ar dtús agus scoite amach ó phlandaí éagsúla, lena n-áirítear Rosa woodsii (duilleoga), Prosopis glandulosa (duilleoga agus craobhóga), Phordendron juniperinum (planda iomlán), Syzygium claviflorum (duilleoga), Hyptis capitata (planda iomlán), agus Ternstromia gymnanthera (chuid ón aer). speiceas Syzygium eile lena n-áirítear úll java (Syzygium samarangense) agus d'ardaigh úll Go bhfuil sé s.

Ainm Táirge: oleanolic Aigéad  98 %

Sonraíocht: 98% de réir HPLC

Lus Foinse: Olea EORPAIGH Sliocht

Ainm Cheimiceach: (3β) -3-Hydroxyolean-12-en-28-Oifig an Choimisinéara Faisnéise aigéad

CAS No: 508-02-1

Cuid Úsáidte: Leaf

Dath: Púdar bán le boladh sainiúil agus blas

Stádas GMO: GMO Saor

Pacáil: 25kgs in drumaí snáithín

Stóráil: Coinnigh coimeádán oscailt in áit, fionnuar tirim, Choinneáil ar shiúl ó solas láidir

Saol Scairbh: 24 mhí ó dháta an táirgthe

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Feidhm:

Is aigéad 1.Oleanolic sách neamhthocsaineach, antitumor, agus hepatoprotective, chomh maith le taispeáint airíonna antiviral.
Fuarthas go raibh aigéad 2.Oleanolic a chur ar taispeáint láidir frith-VEID.
Is aigéad 3.Oleanolic protector mór de chealla in aghaidh ocsaídiúcháin agus strus electrophile.
Tá aigéad 4.Oleanolic bhfeidhm go mór ar trating heipitíteas víreas, heipitíteas icteric géara agus heipitíteas ainsealach.
Feidhmchlár:
1. Fheidhmeach i réimse an bia is féidir, gníomhaíonn sé mar amhábhair tae phlegm a laghdú;
2. Fheidhmeach i réimse na cógaisíochta, bíonn sé ina drugaí nua frith-ailse le íseal tocsaineach;
3. Fheidhmeach i réimse cosmaideacha, is féidir é a invigorate scaipeadh fola agus bain dí.