Oleanolic Acid Powder

Oleanolic acid na kung saan ay isang tatlong pentacyclic triterpenoids ihiwalay mula Gentianaceae halaman ng Swertia mileensis ang buong damo o privet prutas, na may isang libreng katawan at glycosides sa maraming mga halaman. Oleanolic acid ay may isang malawak na hanay sa mga halaman, at ang average na nilalaman ay 0.2% - 2%. Cucurbitaceae mataas na nilalaman ay 1.5% ~ kuba ibaba 2%, privet prutas nilalaman ng 0.6% ~ 0.7% .Oleanolic acid ay isang uri ng pentacyclic triterpenoid tambalang ihiwalay mula sa mga bunga ng genus Asteraceae, Syzygium sylvestris, o Ligustrum lucidum. Ito ay isang sakit sa atay adjuvant at clinically ginagamit para sa panterapeutika impeksiyon. Talamak paninilaw ng balat hepatitis ay halata epekto sa pagbabawas ng alanine aminotransferase at yellowing.Oolic acid ay isang pentacyclic triterpenoids ihiwalay mula sa mga bunga ng Swertia chinensis o fructus ligustris mula sa gentianaceae halaman. Oleanolic acid ay malawakang natagpuan sa mga halaman, na may isang pangkalahatang nilalaman ng 0.2% ~ 2% [1]. Ang nilalaman ng ibaba ng kalabas ay 1.5% ~ 2%, at ang nilalaman ng bunga ng fructus ligustris ay 0.6% ~ 0.7%. Oleanolic acid ay puti acicular kristal (ethanol), walang amoy at hindi masarap. Hindi Matatag na asido at base. Temperatura ng pagkatunaw 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, kloropormo, hindi malulutas sa tubig, natutunaw sa methanol, ethanol, eter, acetone at chloroform.Oleanolic acid ay isang natural na nagaganap triterpenoid, malawak na ipinamamahagi sa pagkain at panggamot halaman, na may kaugnayan sa betulinic acid. maaari itong matagpuan sa Phytolacca americana (American pokeweed), at Syzygium spp, bawang, atbp Ito ay relatibong non-nakakalason, hepatoprotective, at exhibits anti-tumor at antiviral properties.
oleanolic acid ay ang nahanap sa eksibit malakas na aktibidad na anti-HIV, ang mga kaugnay na compound betulinic acid ay ginagamit upang lumikha ng unang komersyal na pagkahinog inhibitor gamot. Ito ay unang nag-aral at ihiwalay mula sa ilang mga halaman, kabilang Rosa woodsii (dahon), Prosopis glandulosa (dahon at twigs), Phordendron juniperinum (buong planta), Syzygium claviflorum (dahon), Hyptis capitata (buong planta), at Ternstromia gymnanthera (aerial bahagi). Iba pang mga Syzygium species kabilang ang java apple (makopa) at rose apple s maglaman ito.

Pangalan ng Produkto: oleanolic acid  98 %

Specification: 98% sa pamamagitan ng HPLC

Botanic Source: Olea Europea Extract

Chemical Pangalan: (3β) -3-Hydroxyolean-12-en-28-oic acid

Cas No: 508-02-1

Bahagi Ginamit: Leaf

Kulay: White pulbos na may katangi-amoy at lasa

Katayuan sa GMO: GMO Free

Packing: sa 25kgs fiber drums

Imbakan: Panatilihin ang lalagyan di pa nabubuksang sa mga cool na, tuyo na lugar, Panatilihin ang layo mula sa malakas na ilaw

Shelf Life: 24 buwan mula sa petsa ng produksyon

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Function:

1.Oleanolic acid ay relatibong non-nakakalason, anti-tumor, at hepatoprotective, pati na rin exhibiting antiviral properties.
2.Oleanolic acid ay natagpuan na nagpapakita ng malakas na aktibidad na anti-HIV.
3.Oleanolic acid ay isang pangunahing tagapagtanggol ng mga cell laban sa oxidative at electrophile stress.
4.Oleanolic acid ay may mahusay na epekto sa nahahadlangan virus hepatitis, talamak na may paninilaw ng balat hepatitis at talamak sakit sa atay.
application:
1. Inilapat sa larangan na pagkain, kaya nito ay gumaganap bilang raw na materyales ng tsaa upang mabawasan ang plema;
2. Inilapat sa pharmaceutical patlang, ito ay nagiging isang bagong anti-kanser na gamot na may mababang nakakalason;
3. Inilapat sa cosmetic patlang, maaari itong pasiglahin ang sirkulasyon ng dugo at alisin ang inumin.