Oleanolic Acid Powder

Oleanolic acid eyi ti o jẹ a mẹta pentacyclic triterpenoids ya sọtọ lati Gentianaceae eweko ti Swertia mileensis gbogbo koriko tabi privet eso, pẹlu kan free ara ati glycosides ni ọpọlọpọ awọn eweko. Oleanolic acid ni o ni kan jakejado ibiti o ni eweko, ati awọn apapọ akoonu jẹ 0.2% - 2%. Cucurbitaceae ga akoonu jẹ 1.5% ~ hunchback isalẹ 2%, privet eso akoonu ti 0.6% ~ 0,7% .Oleanolic acid ni a irú ti pentacyclic triterpenoid yellow ya sọtọ lati eso ti awọn iwin Asteraceae, Syzygium sylvestris, tabi Ligustrum lucidum. O ti wa ni a ẹdọ arun adjuvant ati aarun lo fun mba ikolu. Ńlá jaundice jedojedo ni o ni kedere ipa lori olorijori ti alanine aminotransferase ati yellowing.Oolic acid ni a pentacyclic triterpenoids ya sọtọ lati eso swertia chinensis tabi fructus ligustris lati gentianaceae ọgbin. Oleanolic acid ni o gbajumo ri ni eweko, pẹlu kan gbogbo akoonu ti 0.2% ~ 2% [1]. Awọn akoonu ti isalẹ ti igba wà 1.5% ~ 2%, ati awọn akoonu ti eso ti fructus ligustris wà 0.6% ~ 0,7%. Oleanolic acid ni funfun acicular gara (ẹmu), odorless ati obu. Riru to acids ati ìtẹlẹ. Yo ojuami ti 308 ~ 310 ℃, [Alpha] 20 d + 73.3 ° (c = 0.15, chloroform, insoluble ninu omi, tiotuka ninu kẹmika, ẹmu, ethyl ether, acetone ati chloroform.Oleanolic acid ni a nipa ti sẹlẹ ni triterpenoid, ni opolopo pin ni ounje ati ti oogun eweko, jẹmọ si betulinic acid. O le wa ni ri ni Phytolacca americana (American pokeweed), ati Syzygium spp, ata, bbl O ti wa ni jo ti kii-majele ti, hepatoprotective, ati ifihan antitumor ati antiviral-ini.
Oleanolic acid je ri lati maa lagbara egboogi-HIV aṣayan iṣẹ-ṣiṣe, awọn ti o ni ibatan yellow betulinic acid a lo lati ṣẹda awọn akọkọ ti owo maturation onidalẹkun oògùn. O ti a ti akọkọ iwadi ati ya sọtọ lati orisirisi awọn eweko, pẹlu Rosa woodsii (leaves), Prosopis glandulosa (leaves ati eka), Phordendron juniperinum (gbogbo ọgbin), Syzygium claviflorum (leaves), Hyptis capitata (gbogbo ọgbin), ati Ternstromia gymnanthera (eriali apa). Miiran Syzygium eya pẹlu Java apple (Syzygium samarangense) ati si dide apple s ni o.

Ọja orukọ: Oleanolic Acid  98 %

Specification: 98% nipa HPLC

Botanic Orisun: Olea Europea jade

Chemical Name: (3β) -3-Hydroxyolean-12-en-28-OIC acid

CAS No: 508-02-1

Apá lo: bunkun

Awọ: funfun lulú pẹlu iwa awọn wònyí ati ki o lenu

GMO Ipo: GMO Free

Iṣakojọpọ: ni 25kgs fiber ilu ti n lu

Ibi: Jeki eiyan unopened ni itura, gbẹ ibi, Jeki kuro lati lagbara ina

Selifu Life: 24 osu lati ọjọ ti gbóògì

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

iṣẹ:

1.Oleanolic acid ni jo ti kii-majele ti, antitumor, ati hepatoprotective, bi daradara bi latile antiviral-ini.
2.Oleanolic acid a ri lati maa lagbara egboogi-HIV aṣayan iṣẹ-ṣiṣe.
3.Oleanolic acid ni pataki kan Olugbeja ti ẹyin si ti oyi ati electrophile wahala.
4.Oleanolic acid ni o ni nla ipa lori trating kokoro jedojedo, ńlá icteric jedojedo ati onibaje jedojedo.
ohun elo:
1. Applied ni ounje oko, o le ìgbésẹ bi aise ohun elo tii lati din kẹlẹbẹ;
2. Applied ni elegbogi oko, o di titun kan egboogi-akàn oògùn pẹlu kekere majele ti;
3. Applied ni ohun ikunra oko, o le invigorate ẹjẹ san ki o si yọ nkanmimu.