Oleanolic Acid Powder

Oleanolic skābe, kas ir trīs pentacyclic triterpenoids izolēti no Gentianaceae augiem Swertia mileensis visu zāli vai privet augļus, ar bezmaksas ķermeni un glikozīdi daudzās iekārtās. Oleanolic skābe ir plašs iekārtās, un vidējais saturs ir 0,2% - 2%. Ķirbju dzimta augsts saturs ir 1,5% ~ kuprītis bottom 2%, privet augļi saturs no 0.6% ~ 0.7% .Oleanolic skābes ir sava veida pentacyclic triterpēnu savienojuma, kas izolēts no ģints augļu Asteraceae, Syzygium sylvestris, vai Ligustrum lucidum. Tā ir aknu slimība adjuvants un klīniski izmanto terapeitiskā infekciju. Akūta dzelte hepatīts ir acīmredzama ietekme uz samazinot alanīna aminotransferāzes un yellowing.Oolic skābe ir pentacyclic triterpenoids izolēta no augļiem swertia chinensis vai fructus ligustris no gentianaceae auga. Oleanolic skābe ir plaši atrodami augi, ar vispārēju saturu 0,2% ~ 2% [1]. No apakšas Calabash saturs bija 1,5% ~ 2%, un saturs augļiem fructus ligustris bija 0,6% ~ 0.7%. Oleanolic skābe ir balts acicular kristāls (etanols), bez smaržas un garšas. Nestabila skābēm un bāzēm. Kušanas temperatūra 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, hloroforms, nešķīst ūdenī, šķīst metanolā, etanolā, etilacetāts, dietilēteris, acetons un chloroform.Oleanolic skābe ir dabiskas izcelsmes triterpēnu, plaši izplatīts pārtikas un ārstniecības augiem, kas saistīti ar betulinic skābi. to var atrast Fitolaku dzimtas americana (American pokeweed) un Syzygium spp, ķiplokiem, uc Tas ir salīdzinoši nav toksisks, aknas, un eksponāti pretaudzēju un pretvīrusu īpašības.
Oleanolic acid bija konstatēts, piemīt spēcīga anti-HIV aktivitāti, ar to saistītais savienojums betulinic skābes tika izmantoti, lai izveidotu pirmo komerciālo nobriešanas inhibitora zāles. vispirms tika pētīta un izolēts no vairākiem augiem, ieskaitot Rosa woodsii (lapas), Prosopis glandulosa (lapām un zariem); Phordendron juniperinum (viss augs), Syzygium claviflorum (lapas), Hyptis capitata (viss augs), un Ternstromia gymnanthera (antenas daļa). Pārējās Syzygium sugas, tostarp java ābols (Syzygium samarangense) un rožu ābols s satur to.

Produkta nosaukums: Oleanolic Acid  98 %

Specifikācija: 98% ar HPLC

Botāniskais Avots: Olea Europea ekstrakts

Ķīmiskais nosaukums: (3β) -3-Hydroxyolean-12-en-28-OIC acid

CAS Nr: 508-02-1

Daļa lietota: Leaf

Krāsa: Balts pulveris ar raksturīgu smaržu un garšu

ĢMO Statuss: ĢMO brīva

Iepakojums: in 25kgs šķiedras bungas

Uzglabāšana: Uzglabāt neatvērts vēsā, sausā vietā Glabāt prom no spēcīgas gaismas

Uzglabāšanas laiks: 24 mēneši no ražošanas datuma

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Funkcija:

1.Oleanolic skābe ir relatīvi netoksisku, pretaudzēju, un aknas, kā arī uzrāda pretvīrusu īpašības.
2.Oleanolic acid tika konstatēts, tiem piemīt spēcīga anti-HIV aktivitāti.
3.Oleanolic skābe ir galvenais aizsargs šūnu pret oksidatīvu un elektrofīlu stress.
4.Oleanolic skābe ir liela ietekme uz īpaši izskatot vīrusu hepatīts, akūtu icteric hepatīts un hronisku hepatītu.
Pielietojums:
1. Lietišķā pārtikas nozarē, tas var darbojas kā izejvielu tējas samazināt flegma;
2. Applied farmācijā, tas kļūst par jaunu pretvēža zāles ar zemu toksisks;
3. Lietišķā kosmētikas jomā, tā var uzmundrina asinsriti un noņemt dzērienu.