ກົດ Oleanolic ທີ່ເປັນສາມ triterpenoids pentacyclic ຫ່າງໄກສອກຫລີກຈາກພືດ GENTIANACEAE ຂອງ Swertia mileensis ຫຍ້າຫຼື privet ທັງຫມົດຫມາກໄມ້, ທີ່ມີຮ່າງກາຍແລະ glycoside ທີ່ໃນພືດຈໍານວນຫຼາຍ. ກົດ Oleanolic ມີລະດັບຄວາມກ້ວາງໃນການປູກ, ແລະເນື້ອໃນໂດຍສະເລ່ຍແມ່ນ 02% - 2%. Cucurbitaceae ເນື້ອຫາສູງຄື 15% ~ hunchback ລຸ່ມ 2%, ເນື້ອຫມາກ privet 0,6% ~ 07% .Oleanolic ກົດແມ່ນປະເພດຂອງການປະສົມ triterpenoid pentacyclic ຫ່າງໄກສອກຫລີກຈາກຫມາກຂອງສະກຸນ Asteraceae, Syzygium sylvestris ຫລື Ligustrum lucidum ໄດ້. ມັນເປັນ adjuvant ພະຍາດຕັບແລະນໍາໃຊ້ຫ້ອງການຊ່ວຍເຫຼືອສໍາລັບພະຍາດຊຶມເຊື້ອ therapeutic. ພະຍາດຫມາກເຫຼືອງອັກເສບຕັບສຽບພັນມີຜົນກະທົບທີ່ຊັດເຈນກ່ຽວກັບການຫຼຸດຜ່ອນ aminotransferase Alanine ແລະກົດ yellowing.Oolic ເປັນ triterpenoids pentacyclic ຫ່າງໄກສອກຫລີກຈາກຫມາກຂອງ chinensis swertia ຫຼື Fructus ໄດ້ ligustris ຈາກພືດ GENTIANACEAE ໄດ້. ກົດ Oleanolic ໄດ້ຖືກພົບເຫັນຢ່າງກວ້າງຂວາງໃນການປູກ, ທີ່ມີເນື້ອໃນໂດຍທົ່ວໄປຂອງ 02% ~ 2% [1]. ເນື້ອໃນຂອງທາງລຸ່ມຂອງນ້ໍາເຕົ້າແມ່ນ 1.5% ~ 2%, ແລະເນື້ອໃນຂອງຫມາກຂອງ ligustris Fructus ແມ່ນ 06% ~ 07%. ກົດ Oleanolic ເປັນສີຂາວໄປເຊຍກັນ acicular (ethanol), ບໍ່ມີກິ່ນແລະ tasteless. Unstable ກັບອາຊິດແລະຖານ. ຈຸດຂອງ 308 ~ 310 Melting ℃, [alpha] 20 d + 733 ° (c = 015, chloroform, insoluble ໃນນ້ໍາ, ລະລາຍໃນ methanol, ethanol, ethyl ether, ນໍ້າຍາລ້າງເລັບແລະກົດ chloroform.Oleanolic ເປັນ triterpenoid ທໍາມະຊາດເກີດ, ແຈກຢາຍຢ່າງກວ້າງຂວາງ ໃນອາຫານແລະໃຊ້ເປັນຢາພືດທີ່ກ່ຽວຂ້ອງກັບກົດ betulinic. ມັນສາມາດໄດ້ຮັບການພົບເຫັນຢູ່ໃນ Phytolacca americana (American pokeweed), ແລະ Syzygium spp, ຜັກທຽມ, ແລະອື່ນໆມັນແມ່ນຂ້ອນຂ້າງທີ່ບໍ່ແມ່ນເປັນສານພິດ, hepatoprotective, ແລະງານວາງສະແດງຕ້ານ tumor ແລະຄຸນສົມບັດຕ້ານເຊື້ອໄວຣັ.
ກົດ Oleanolic ແມ່ນ ພົບກັບສະແດງກິດຈະກໍາຕໍ່ຕ້ານເຊື້ອໂລກເອດສທີ່ເຂັ້ມແຂງ, ປະສົມທີ່ກ່ຽວຂ້ອງກົດ betulinic ໄດ້ຖືກນໍາໃຊ້ເພື່ອສ້າງການຄ້າຢາເສບຕິດການເຕີບໂຕເຕັມ inhibitor ຄັ້ງທໍາອິດ. ມັນໄດ້ສຶກສາຄັ້ງທໍາອິດແລະຫ່າງໄກສອກຫລີກຈາກພືດຈໍານວນຫນຶ່ງ, ລວມທັງ Rosa woodsii (ໃບ), Prosopis glandulosa (ໃບແລະກິ່ງງ່າ), Phordendron juniperinum (ພືດທັງຫມົດ), Syzygium claviflorum (ໃບ), Hyptis capitata (ພືດທັງຫມົດ), ແລະ Ternstromia gymnanthera (ສ່ວນທາງອາກາດ). ຊະນິດ Syzygium ອື່ນ ໆ ລວມທັງ java ຈາກຫນາກແອບເປີ (Syzygium samarangense) ແລະເພີ່ມຂຶ້ນຈາກຫນາກແອບເປີ s ບັນຈຸມີມັນ.
ຊື່ຜະລິດຕະພັນ: Oleanolic Acid 98 %
ຂໍ້ມູນຈໍາເພາະ: 98% ໂດຍ HPLC
ແຫຼ່ງຂໍ້ມູນສະນະພືດສາດ: Olea Europea Extract
ຊື່ທາງເຄມີ: (3β) -3, Hydroxyolean-12-en-28 oic acid
CAS No: 508-02-1
ສ່ວນທີ່ນໍາໃຊ້: ໃບ
ສີ: ແປ້ງສີຂາວທີ່ມີກິ່ນລັກສະນະແລະລົດຊາດ
ສະຖານະ GMO: GMO ຟຣີ
ການບັນຈຸ: ໃນ 25kg drums ໄຟເບີ
ການເກັບຮັກສາພາຊະນະໃຫ້ຍັງບໍ່ໄດ້ເປີດໃນເຢັນ, ສະຖານທີ່ແຫ້ງ, ເກັບໃຫ້ຫ່າງຈາກແສງສະຫວ່າງທີ່ເຂັ້ມແຂງ
Shelf ຊີວິດ: 24 ເດືອນຈາກວັນທີຂອງການຜະລິດ
What is oleanolic acid?
Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.
Where can you find oleanolic acid?
Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.
Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.
| Herb Name | Oleanolic acid content | Test method |
| Ligustrum lucidum Ait | 0.8028% | HPLC |
| Verbena Officinalis L | 0.071%-0.086% | HPLC |
| Prunella vulgaris L | 3.47%-4.46% | HPLC |
| Hemsley Chinensis Cogn. | 1.5%～2% | HPLC |
Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.
Hemsley Chinensis Cogn. Introduction
Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.
Familia: Cucurbitaceae
Tribus: Gomphogyneae
Genus: Hemsleya
Species: H. amabilis
The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.
Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate; Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.
Medicinal Values:
Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.
Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.
Formulas containing Oleanolic acid in Food supplements
We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.
- Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
- Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
- Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)
Oleanolic acid VS Ursolic acid
Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.
These triterpenoids compounds are known to exist in medicinal herbs and foods.
They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.
OA and UA difference:
| ຊື່ຜະລິດຕະພັນ | Oleanolic acid | Ursolic acid |
| CAS NO. | 508-02-1 | 77-52-1 |
| Pentacyclic triterpenes | β-Amyrin | α-Amyrin |
| Herb sources | Loquat leaf, Holy Basil, Rosemary, Olive leaf.etc. | |
| Specifications | 40%,98%powder | 15%,25%,50%,98%powder |
| Appearance(color and odor) | 40% light yellow98%white powderodorless | 15%-50% brown-yellow or yellow98%white powderCharacteristic |
| Distinguishing | IR:(1355~1392cm-1) two peaks(1245~1330cm-1) three peaksNMR:δ(C12)122.1,δ(C13)143.4 | (1355~1392cm-1) three peaks(1245~1330cm-1) three peaksδ(C12)125.5,δ(C13)138.0 |
| Derivatives | Oleanolic sodium saltOleanolic acid phosphate disodium salt3-oxo oleanolic acid
bardoxolone methyl (CDDO-Me) |
Ursolic sodium salt and its dicarboxylic acid half ester derivativesUrsolic acid ketene derivatives3-carbon ursolic acid
3-acetoxyursolic acid |
| Potential anticancer | UA is more popular than OA. | |
Biological Activities of Oleanolic Acid
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Anti-Tumour/Anti-Cancer Effects
Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis
– by Xin Wang, Hua Bai, etc. Researchers
OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.
OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.
OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.
OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.
In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…
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Antimicrobial Activity
OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.
OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).
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Hepatoprotective Ability
One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.
In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.
Oleanolic Acid and its derivatives
Oleanolic Acid Clinical Trials
Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.
Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.
Chinese Pharmacopoeia Standard of Oleanolic Acid
| ຊື່ຜະລິດຕະພັນ | Oleanolic Acid |
| ຕົວ | (1)Take 30mg of this product, put it in a test tube, add 3ml of chloroform to dissolve, add two drops of sulfuric acid, shake for 5 minutes, the chloroform layer is purple-red. |
| (2)Take about 20mg of this product, add 1ml of acetic anhydride, dissolve it with a slight heat, add sulfuric acid to the purple color, and darken after placing. | |
| (3)Take about 10mg of this product, add vanillin glacial acetic acid solution (take vanillin 0.5g, add 10ml of glacial acetic acid to dissolve, that is) 0.2ml, add 0.8ml of perchloric acid, and heat it for several minutes in a water bath. Fuchsia, add 2ml of ethyl acetate, purple-red dissolved in ethyl acetate, placed without discoloration. | |
| (4)The infrared absorption spectrum of this product should be consistent with the control spectrum. | |
| Determination of assay | Take 0.15g of this product, accurately weigh it, add 30ml of ethanol, shake it, heat it in a warm water bath to dissolve, let cool to room temperature, add 3 drops of phenolphthalein indicator solution, make potassium hydroxide solution with ethanol (0.05mol/L) Titrate immediately and correct for blank test. Potassium hydroxide solution (0.05 mol/L) per 1 ml of ethanol corresponds to 22.84 mg of C30H 48O 3. |
Oleanolic acid recommend dosage
According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.
Oleanolic acid side effects
Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.
If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.
Please consult your physician or pharmacist before using this product.
ຄ່າບໍລິການ
ກົດ 1.Oleanolic ແມ່ນຂ້ອນຂ້າງທີ່ບໍ່ແມ່ນເປັນສານພິດ, ຕ້ານ tumor, ແລະ hepatoprotective, ເຊັ່ນດຽວກັນກັບສະແດງຄຸນສົມບັດຕ້ານເຊື້ອໄວຣັ.
ກົດ 2.Oleanolic ໄດ້ພົບເຫັນການສະແດງກິດຈະກໍາຕໍ່ຕ້ານເຊື້ອໂລກເອດສທີ່ເຂັ້ມແຂງ.
ກົດ 3.Oleanolic ເປັນເຄື່ອງປ້ອງກັນທີ່ສໍາຄັນຂອງຈຸລັງຕ້ານການຜຸພັງແລະຄວາມກົດດັນ electrophile.
ກົດ 4.Oleanolic ມີຜົນກະທົບຢ່າງໃຫຍ່ຫຼວງຕໍ່ trating ຕັບອັກເສບເຊື້ອໄວຣັສ, ຕັບອັກເສບ icteric ໃບສ້ວຍແຫຼມແລະຊໍາເຮື້ອຕັບ.
ຄໍາຮ້ອງສະຫມັກ:
1. ນໍາໃຊ້ໃນພາກສະຫນາມອາຫານ, ມັນສາມາດເຮັດໄດ້ເຮັດຫນ້າທີ່ເປັນວັດຖຸດິບຂອງຊາທີ່ຈະຫຼຸດຜ່ອນຂີ້ກະເທີ່;
2. ນໍາໃຊ້ໃນພາກສະຫນາມຢາ, ມັນຈະກາຍເປັນຢາເສບຕິດການຕ້ານການເປັນມະເຮັງໃຫມ່ທີ່ມີພິດຕ່ໍາ;
3. ນໍາໃຊ້ໃນພາກສະຫນາມເຄື່ອງສໍາອາງ, ມັນສາມາດກະຕຸ້ນການໄຫຼວຽນຂອງເລືອດແລະເອົາເຄື່ອງດື່ມ.
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ຂໍ້ມູນເພີ່ມເຕີມຂອງ TRB |
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| ການຮັບຮອງລະບຽບ | ||
| USFDA, ຫັດໄປສະນີ, HALAL KOSHER ໃບຢັ້ງຢືນ ISO GMP | ||
| ຄຸນນະພາບທີ່ເຊື່ອຖືໄດ້ | ||
| ເກືອບ 20 ປີ, ການສົ່ງອອກ 40 ປະເທດແລະຂົງເຂດ, ຫຼາຍກ່ວາ 2000 ຂະບວນການຜະລິດໂດຍ TRB ມີບັນຫາໃດໆຄຸນນະພາບ, ຂະບວນການການກັ່ນຕອງຊ້ໍາກັນ, ຄວາມບໍລິສຸດແລະການຄວບຄຸມຄວາມບໍລິສຸດຕອບສະຫນອງ USP, EP ແລະ CP | ||
| ລະບົບຄຸນນະພາບທີ່ສົມບູນແບບ | ||
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| ▲ລະບົບການຄວບຄຸມ Laboratory |
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| ແຫລ່ງທີ່ມາທັງຫມົດການຄວບຄຸມແລະຂະບວນການ | ||
| ສາມາດຄວບຄຸມຢ່າງເຂັ້ມງວດທັງຫມົດອຸປະກອນການເປັນວັດຖຸດິບ, ອຸປະກອນເສີມແລະການຫຸ້ມຫໍ່ materials.Preferred ອຸປະກອນແລະອຸປະກອນເສີມແລະອຸປະກອນການຫຸ້ມຫໍ່ດິບສະຫນອງກັບສະຫະລັດ DMF number.Several ຜູ້ສະຫນອງວັດຖຸດິບເປັນການຮັບປະກັນການສະຫນອງ. | ||
| ສະຖາບັນສະຫະກອນທີ່ເຂັ້ມແຂງທີ່ຈະສະຫນັບສະຫນູນ | ||
| ສະຖາບັນຂອງ botany / ສະຖາບັນຂອງ microbiology / Academy of Science and Technology / University | ||
