Wholesale Oleanolic Acid powder manufacturers and suppliers | Tong Rui Bio-Tech

Oleanolic Acid Powder

Deskripsi Singkat:

asam oleanolic ditemukan menunjukkan aktivitas anti-HIV yang kuat, asam betulinic senyawa terkait digunakan untuk membuat obat pematangan inhibitor komersial pertama. Ini pertama kali dipelajari dan diisolasi dari beberapa tanaman, termasuk Rosa woodsii (daun), Prosopis glandulosa (daun dan ranting), Phordendron juniperinum (seluruh tanaman), Syzygium claviflorum (daun), Hyptis capitata (seluruh tanaman), dan Ternstromia gymnanthera (aerial bagian). Spesies Syzygium lainnya termasuk java apple (jambu semarang) dan naik apel mengandung itu.


  • FOB Harga: US $0.5 - 2000 / KG
  • Min.order Jumlah: 1 KG
  • Kemampuan Supply: 10000 KG / per Bulan
  • Port: SHANGHAI / BEIJING
  • Ketentuan Pembayaran: L / C, D / A, D / P, T / T
  • :
  • Rincian produk

    Tags produk

    Asam oleanolic yang merupakan tiga triterpenoid pentasiklik diisolasi dari gentianaceae tanaman dari Swertia mileensis seluruh rumput atau privet buah, dengan tubuh bebas dan glikosida dalam banyak tanaman. Asam oleanolic memiliki berbagai macam tanaman, dan kandungan rata-rata 0,2% - 2%. Cucurbitaceae konten tinggi 1,5% ~ bungkuk bawah 2%, privet konten buah 0,6% ~ 0,7% .Oleanolic asam adalah sejenis senyawa triterpenoid pentasiklik diisolasi dari buah dari genus Asteraceae, Syzygium sylvestris, atau Ligustrum lucidum. Ini adalah ajuvan penyakit hati dan klinis digunakan untuk infeksi terapi. Akut ikterus hepatitis memiliki efek yang jelas pada pengurangan SGPT dan asam yellowing.Oolic adalah triterpenoid pentasiklik diisolasi dari buah swertia chinensis atau fructus ligustris dari tanaman gentianaceae. Asam oleanolic secara luas ditemukan pada tumbuhan, dengan kandungan umum 0,2% ~ 2% [1]. Isi dari bawah labu adalah 1,5% ~ 2%, dan kandungan buah ligustris fructus adalah 0,6% ~ 0,7%. Asam oleanolic putih kristal acicular (etanol), tidak berbau dan berasa. Stabil terhadap asam dan basa. Titik 308 ~ 310 mencair ℃, [alpha] 20 d + 73,3 ° (c = 0,15, kloroform, tidak larut dalam air, larut dalam metanol, etanol, etil eter, aseton dan asam chloroform.Oleanolic adalah triterpenoid alami, didistribusikan secara luas dalam makanan dan obat tanaman, terkait dengan asam betulinic. Hal ini dapat ditemukan di Phytolacca americana (Amerika pokeweed), dan Syzygium spp, bawang putih, dll Hal ini relatif tidak beracun, hepatoprotektif, dan pameran antitumor dan antivirus.
    asam oleanolic adalah ditemukan menunjukkan aktivitas anti-HIV yang kuat, asam betulinic senyawa terkait digunakan untuk membuat obat pematangan inhibitor komersial pertama. ini pertama kali dipelajari dan diisolasi dari beberapa tanaman, termasuk Rosa woodsii (daun), Prosopis glandulosa (daun dan ranting), Phordendron juniperinum (seluruh tanaman), Syzygium claviflorum (daun), Hyptis capitata (seluruh tanaman), dan Ternstromia gymnanthera (bagian udara). spesies Syzygium lain termasuk java apple (jambu semarang) dan jambu s berisi itu.

     

    Nama Produk: oleanolic Acid  98 %

    Keterangan: 98% dengan HPLC

    Botanic Sumber: Olea Europea Extract

    Nama Kimia: (3β) -3-Hydroxyolean-12-en-28-OKI asam

    CAS No: 508-02-1

    Bagian Digunakan: Daun

    Warna: Serbuk putih dengan bau yang khas dan rasa

    Status GMO: GMO Gratis

    Packing: 25kgs di drum fiber

    Penyimpanan: Simpan wadah yang belum dibuka dalam sejuk dan kering, Jauhkan dari cahaya yang kuat

    Shelf Life: 24 bulan dari tanggal produksi

     

    What is oleanolic acid?

    Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

    Oleanolic acid structure

    Where can you find oleanolic acid?

    Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

    Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

    oleanolic acid sources

    Herb Name Oleanolic acid content Test method
    Ligustrum lucidum Ait 0.8028% HPLC
    Verbena Officinalis L 0.071%-0.086% HPLC
    Prunella vulgaris L 3.47%-4.46% HPLC
    Hemsley Chinensis Cogn. 1.5%~2% HPLC

    Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

    Hemsley Chinensis Cogn. Introduction

    Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

    Familia: Cucurbitaceae

    Tribus: Gomphogyneae

    Genus: Hemsleya

    Species: H. amabilis

    The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

    Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

    Medicinal Values:

    Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

    Hemsleya chinensis Cogn

    Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

    Oleanolic acid manufacturing

    Formulas containing Oleanolic acid in Food supplements

    We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

    • Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
    • Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
    • Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

    Oleanolic acid FORMULA

    Oleanolic acid VS Ursolic acid

    Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

    These triterpenoids compounds are known to exist in medicinal herbs and foods.

    They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

    Oleanolic acid VS Ursolic acid comparison

    OA and UA difference:

    Nama Produk Oleanolic acid Ursolic acid
    CAS NO. 508-02-1 77-52-1
    Pentacyclic triterpenes  β-Amyrin α-Amyrin
    Herb sources Loquat leaf, Holy Basil, Rosemary, Olive leaf.etc.
    Specifications 40%,98%powder 15%,25%,50%,98%powder
    Appearance(color and odor) 40% light yellow98%white powderodorless 15%-50% brown-yellow or yellow98%white powderCharacteristic
    Distinguishing IR:(1355~1392cm-1) two peaks(1245~1330cm-1) three peaksNMR:δ(C12)122.1,δ(C13)143.4 (1355~1392cm-1) three peaks(1245~1330cm-1) three peaksδ(C12)125.5,δ(C13)138.0
    Derivatives Oleanolic sodium saltOleanolic acid phosphate disodium salt3-oxo oleanolic acid

    bardoxolone methyl (CDDO-Me)

    Ursolic sodium salt and its dicarboxylic acid half ester derivativesUrsolic acid ketene derivatives3-carbon ursolic acid

    3-acetoxyursolic acid

    Potential anticancer UA is more popular than OA.

    Biological Activities of Oleanolic Acid

    1. Anti-Tumour/Anti-Cancer Effects

    Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

     – by Xin Wang, Hua Bai, etc. Researchers

    OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

    OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

    OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

    OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

    In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

    Oleanolic Acid benefits

    1. Antimicrobial Activity

    OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

    OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

    1. Hepatoprotective Ability

    One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

    In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

    Oleanolic Acid and its derivatives

    Oleanolic Acid and its derivatives

    Oleanolic Acid Clinical Trials

    Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

    Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

     

    Chinese Pharmacopoeia Standard of Oleanolic Acid

    Nama produk Oleanolic Acid
    Identifikasi (1)Take 30mg of this product, put it in a test tube, add 3ml of chloroform to dissolve, add two drops of sulfuric acid, shake for 5 minutes, the chloroform layer is purple-red.
    (2)Take about 20mg of this product, add 1ml of acetic anhydride, dissolve it with a slight heat, add sulfuric acid to the purple color, and darken after placing.
    (3)Take about 10mg of this product, add vanillin glacial acetic acid solution (take vanillin 0.5g, add 10ml of glacial acetic acid to dissolve, that is) 0.2ml, add 0.8ml of perchloric acid, and heat it for several minutes in a water bath. Fuchsia, add 2ml of ethyl acetate, purple-red dissolved in ethyl acetate, placed without discoloration.
    (4)The infrared absorption spectrum of this product should be consistent with the control spectrum.
    Determination of assay Take 0.15g of this product, accurately weigh it, add 30ml of ethanol, shake it, heat it in a warm water bath to dissolve, let cool to room temperature, add 3 drops of phenolphthalein indicator solution, make potassium hydroxide solution with ethanol (0.05mol/L) Titrate immediately and correct for blank test. Potassium hydroxide solution (0.05 mol/L) per 1 ml of ethanol corresponds to 22.84 mg of C30H 48O 3.

    Oleanolic acid recommend dosage

    According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

    Oleanolic acid side effects

    Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

    If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

    Please consult your physician or pharmacist before using this product.

    Fungsi:

    Asam 1.Oleanolic relatif non-toksik, antitumor, dan hepatoprotektif, serta menunjukkan sifat antivirus.
    Asam 2.Oleanolic ditemukan menunjukkan aktivitas anti-HIV yang kuat.
    Asam 3.Oleanolic adalah pelindung utama dari sel-sel terhadap stres oksidatif dan elektrofil.
    Asam 4.Oleanolic memiliki efek yang besar pada melakukan bentuk virus hepatitis, hepatitis ikterik akut dan hepatitis kronis.
    Aplikasi:
    1. Terapan di bidang makanan, dapat bertindak sebagai bahan baku teh untuk mengurangi dahak;
    2. Terapan di bidang farmasi, menjadi obat anti-kanker baru dengan beracun rendah;
    3. Terapan di bidang kosmetik, dapat memperkuat sirkulasi darah dan menghapus minuman.

     

     

     

    Informasi lebih lanjut dari TRB

    sertifikasi Peraturan
    USFDA, CEP, halal HALAL GMP Sertifikat ISO
    Kualitas terpercaya
    Hampir 20 tahun, ekspor 40 negara dan wilayah, lebih dari 2000 batch yang diproduksi oleh TRB tidak memiliki masalah kualitas, proses pemurnian unik, kenajisan dan kontrol kemurnian bertemu USP, EP dan CP
    Sistem Mutu Komprehensif

     

    ▲ Sistem Penjaminan Mutu

    ▲ kontrol Dokumen

    ▲ Validasi Sistem

    ▲ Pelatihan Sistem

    ▲ Audit Internal Protocol

    ▲ Sistem Audit Suppler

    ▲ Peralatan Fasilitas Sistem

    ▲ Bahan Sistem Kontrol

    ▲ Sistem Pengendalian Produksi

    ▲ Kemasan Sistem Pelabelan

    ▲ Laboratorium Sistem Kontrol

    ▲ Sistem Verifikasi Validasi

    ▲ Regulatory Affairs Sistem

    Sumber dan Proses Whole kontrol
    Dikontrol secara ketat semua bahan baku, aksesori dan kemasan materials.Preferred bahan dan aksesoris dan bahan kemasan baku pemasok dengan US DMF number.Several pemasok bahan baku sebagai jaminan pasokan.
    Lembaga Koperasi yang kuat untuk mendukung
    Institute of botani / Institusi mikrobiologi / Akademi Sains dan Teknologi / Universitas

     


  • Sebelumnya:
  • Berikutnya: