Oleanolic Acid Powder

Oleanolic acid nga mao ang usa ka sa tulo ka pentacyclic triterpenoids-inusara gikan Gentianaceae mga tanom sa Swertia mileensis sa tibuok balili o privet bunga, uban sa usa ka libre nga lawas ug glycosides sa daghan nga mga tanom. Oleanolic acid adunay usa ka halapad nga-laing sa mga tanom, ug ang average nga sulod mao ang 0.2% - 2%. Cucurbitaceae hataas nga sulod mao ang 1.5% ~ buktot ubos 2%, privet bunga sulod sa 0.6% ~ 0.7% .Oleanolic acid mao ang usa ka matang sa pentacyclic triterpenoid compound-inusara gikan sa bunga sa henero Asteraceae, Syzygium sylvestris, o Ligustrum lucidum. Kini mao ang usa ka sakit sa atay adjuvant ug clinically nga gigamit alang sa terapyutik impeksyon. Acute jaundice hepatitis adunay klaro nga mga epekto sa pagkunhod alanine aminotransferase ug yellowing.Oolic acid mao ang usa ka pentacyclic triterpenoids-inusara gikan sa bunga sa swertia chinensis o fructus ligustris gikan sa gentianaceae tanom. Oleanolic acid kaylap nga makita diha sa mga tanom, uban sa usa ka kinatibuk-ang sulod sa 0,2% ~ 2% [1]. Ang sulod sa ubos sa tabayag mao 1.5% ~ 2%, ug sa unod sa bunga sa fructus ligustris mao 0.6% ~ 0.7%. Oleanolic acid mao ang puti nga acicular kristal (ethanol), walay baho ug tasteless. Nagabukal sa mga asido ug ang mga ugbokanan. Nagkahilis punto sa 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, ang chloroform, insoluble sa tubig, matunaw sa methanol, ethanol, ethyl ether, acetone ug chloroform.Oleanolic acid mao ang usa ka natural nga nahitabo triterpenoid, kaylap-apod-apod sa pagkaon ug medisina sa mga tanom, nga may kalabutan sa betulinic acid. Kini makita diha sa Phytolacca americana (American pokeweed), ug Syzygium spp, ahos, ug uban pa Kini mao ang medyo dili-makahilo, hepatoprotective, ug exhibits antitumor ug antiviral kabtangan.
Oleanolic acid mao nakaplagan nga ipakita ang lig-on nga kalihokan sa anti-HIV, ang may kalabutan sa compound betulinic acid gigamit sa paghimo sa unang komersyal nga maturation tigdili, tigpugong drug. Kini unang gitun-an ug nahimulag gikan sa pipila ka mga tanom, lakip na ang Rosa woodsii (dahon), Prosopis glandulosa (dahon ug mga sanga), Phordendron juniperinum (bug-os nga tanom), Syzygium claviflorum (dahon), Hyptis capitata (bug-os nga tanom), ug Ternstromia gymnanthera (aerial bahin). Ang ubang mga Syzygium sakop sa henero nga lakip na ang java apple (Syzygium samarangense) ug mitindog mansanas s naglakip niini.

Ngalan Product: Oleanolic Acid  98 %

Paghingalan: 98% sa HPLC

Botanic Source: Olea Europea Kinuha

Chemical Ngalan: (3β) -3-Hydroxyolean-12-en-28-OIC acid

CAS Walay: 508-02-1

Bahin Gigamit: Dahon

Kolor: White powder uban sa kinaiya baho ug lami

Status GMO: GMO Free

Packing: sa 25kgs fiber drums

Pagtipig: Padayon nga sudlanan wala maablihi sa bugnaw, uga nga dapit, Padayon gikan sa lig-on nga kahayag

Shelf Kinabuhi: 24 ka bulan gikan sa petsa sa produksyon

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

function:

1.Oleanolic acid mao ang medyo dili-makahilo, antitumor, ug hepatoprotective, ingon man usab sa magpasundayag antiviral kabtangan.
2.Oleanolic acid nakaplagan nga ipakita ang lig-on nga kalihokan sa anti-HIV.
3.Oleanolic acid mao ang usa ka mayor nga tigpanalipod sa mga selula batok sa oxidative ug electrophile stress.
4.Oleanolic acid adunay dako nga epekto sa trating virus hepatitis, mahait icteric hepatitis ug laygay nga hepatitis.
Paggamit:
1. Applied sa kapatagan sa pagkaon, mahimo kini naglihok ingon nga hilaw nga materyales sa tsa sa pagpakunhod phlegm;
2. Applied sa pharmaceutical uma, kini mahimo nga usa ka bag-o nga anti-cancer drug uban sa ubos nga makahilo;
3. Applied sa cosmetic uma, kini palagsikon sa dugo sa sirkulasyon ug kuhaon ilimnon.