Oleanolic Acid Powder

Asiti Oleanolic tseo ke tse tharo pentacyclic triterpenoids thōko ho tloha dimela Gentianaceae tsa Swertia mileensis kaofela joang kapa privet litholoana, le 'mele oa mahala le glycosides limeleng tse ngata. Asiti Oleanolic na e mengata e fapaneng ka dimela, le dikahare karolelano ke 0,2% - 2%. Cucurbitaceae phahameng le dikahare ke 1.5% ~ hunchback tlase 2%, privet tholoana dikahare tsa tse 0.6% ~ 0.7% .Oleanolic acid e ke mofuta oa pentacyclic triterpenoid komponeng thōko ho tloha litholoana tsa genus Asteraceae, Syzygium alpinum, kapa Ligustrum lucidum. Ke lefu le sebete adjuvant le ea bongaka sebediswa bakeng sa tshwaetso phekolo. Hlobaetsang nyooko lefu la sebete na litla totobetseng ka fokotsa alanine aminotransferase le asiti yellowing.Oolic ke triterpenoids pentacyclic thōko ho tloha litholoana tsa swertia chinensis kapa fructus ligustris tloha dimela gentianaceae. Asiti Oleanolic ho pharaletseng a fumanoa ka dimela, ka dikahare kakaretso ea 0,2% ~ 2% [1]. The dikahare tsa botlaaseng ba calabash ne 1.5% ~ 2%, le diteng tsa litholoana tsa ligustris fructus ne tse 0.6% ~ 0.7%. Asiti Oleanolic e tšoeu acicular kristale (ethanol), odorless le tasteless. Sa tsitsang ho acid le makalana. Qhibiliha ntlha ea 308 ~ 310 ℃, [, alpha] 20: d + 73.3 ° (c = 0,15, chloroform, insoluble ka metsi, qhibilihang ka har'a ka methanol, ethanol, ethyl phenylate, monohalogen acetone le chloroform.Oleanolic acid e ke triterpenoid tlhaho li etsahala, le ajoang ka lijo le meriana dimela, amanang le asiti betulinic. E ka fumanoa ka ho Phytolacca Americana (American pokeweed), le Syzygium spp, konofolo, joalo-joalo Ke batlang e le batho bao e seng chefo, hepatoprotective, le lipontsuoa antitumor le thepa antiviral.
acid e Oleanolic ne fumana ho bontša matla mosebetsi-ba khahlanong le tšoaetso ea HIV, e amana komponeng acid e betulinic ne e sebelisetsoa ho bopa pele khoebo le nonofo ya mmele sesitisa lithethefatsi ho ile pele a ithuta le ka thōko ho tloha dimela tse 'maloa, ho akarelletsa le Rosa woodsii (makhasi a), Prosopis glandulosa (makhasi le makala a)., Phordendron juniperinum (semela kakaretso), Syzygium claviflorum (makhasi a), Hyptis capitata (semela kakaretso), le Ternstromia gymnanthera (teleskopbomlift karolo). Syzygium mefuta e meng ho akarelletsa java, apole (Syzygium samarangense) 'me a tsoha apole 's na le eona.

Lebitso sehlahisoa: Oleanolic acid e  98 %

Ga tlhaloso: 98% ka HPLC

Botaniki Source: Olea Europea ntšang

Lik'hemik'hale Lebitso: (3β) -3-Hydroxyolean-12-en-28-oic acid e

CAS No: 508-02-1

Karolo Sebelisoa: Leaf

Mala: White phofo le monko o bath le tatso

GMO Status: GMO Free

Paka: ka 25kgs faeba meropa

Storage: Boloka setshelo unopened ka pholile, sebaka omileng, Boloka hole khanya le matla

Raka, athe Bophelo: dikgwedi tse 24 ho tloha letsatsing la ho hlahisoeng

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Function:

Asiti 1.Oleanolic ke batlang batho bao e seng chefo, antitumor, le hepatoprotective, hammoho le bontša thepa antiviral.
Asiti 2.Oleanolic ile a fumanoa a ho bontša matla mosebetsi-ba khahlanong le HIV.
Asiti 3.Oleanolic ke mosireletsi e ka sehloohong ea lisele tse khahlanong oxidative le ho imeloa kelellong electrophile.
Asiti 4.Oleanolic ba le phello e matla trating kokoana-hloko lefu la sebete, a hlobaetsang le icteric lefu la sebete le lefu la sebete sa foleng.
kopo:
1. sebelisoa tšimong lijo, ho ka sebetsa joaloka lihlahisoa tse tala tee ho fokotsa tlala likhohlela;
2. sebelisoa tšimong meriana, ho ba le lecha-ba khahlanong le kankere ya iebele lithethefatsi le nang le chefo e tlaase;
3. sebelisoa tšimong setlolo, e ka matlafatsa ajoa mali le ho tlosa seno.