Oleanolic Acid Powder

Oleanolic sýru sem tekur þrjár pentasýkliska triterpenoids hafa verið einangraðar úr Gentianaceae plöntum af Swertia mileensis the heild gras eða privet ávexti, með ókeypis líkama og glýkósíð í mörgum plöntum. Oleanolic sýra hefur upp á að bjóða mikinn í plöntum, og að meðaltali innihald er 0.2% - 2%. Cucurbitaceae Hátt innihald er 1,5% ~ hunchback botni 2%, privet aldinmagn upp á 0,6% ~ 0,7% .Oleanolic sýru er nokkurs konar pentasýkliska tríterpenóíðsapónín efnasamband einangrað úr ávexti ættinni Körfublómaætt, Syzygium sylvestris, eða Ligustrum lucidum. Það er lifrarsjúkdóm hjálparefnið og klínískt eru notuð í lækningaskyni sýkingu. Bráð gula lifrarbólga hefur augljós áhrif á að draga úr virkni alanínamínótransferasa og yellowing.Oolic sýran er pentasýkliska triterpenoids eru einangraðar úr ávexti swertia chinensis eða Fructus ligustris úr gentianaceae álverinu. Oleanolic sýru er víða að finna í plöntum, með almenna innihaldi 0,2% ~ 2% [1]. Innihald botn af Calabash var 1,5% ~ 2%, og innihald ávexti Fructus ligustris var 0,6% ~ 0,7%. Oleanolic sýru er hvítur Tetrahýdrófúran Nállaga kristal (etanól), lyktar- og bragðlaus. Óstöðug að sýrum og bösum. Bræðslumark af 308 ~ 310 ℃, [alpha] 20D + 73.3 ° (c = 0.15, klóróform, óleysanleg í vatni, leysanlegt í metanóli, etanóli, etýleter, aseton og chloroform.Oleanolic sýran er til á náttúrulegan hátt tríterpenóíðsapónín, víða dreift í mat og lyf plöntur, í tengslum við betulinic sýru. Það er hægt að finna í Phytolacca Americana (American pokeweed), og Syzygium spp, hvítlaukur, o.fl. Það er tiltölulega ekki eitrað, hepatoprotective, og sýnir antitumor og veirueyðandi verkun.
oleanolic sýru var í ljós að sýna sterka and-HIV virkni, var tengt efnasamband betulinic sýran sem er notuð til að búa til fyrsta auglýsing þroskun hemlum lyfínu. Það var fyrst rannsökuð og einangrað frá nokkrum plöntum, þar á meðal Rosa woodsii (lauf), Prosopis glandulosa (lauf og twigs), Phordendron juniperinum (Hvönnin), Syzygium claviflorum (lauf), Hyptis capitata (heild álversins), og Ternstromia gymnanthera (loftnet hluti). Aðrar tegundir Syzygium þ.mt Java epli (Syzygium samarangense) og hækkaði epli s innihalda það.

Vöruheiti: oleanolic Acid  98 %

Specification: 98% með HPLC

Botanic Heimild: Olea Europea Útdráttur

Chemical Name: (3β) -3-Hydroxyolean-12-en-28-ó sýru

CAS nr: 508-02-1

Hluti Notað: Leaf

Litur: Hvítt duft með einkennandi lykt og bragð

GMO Staða: GMO Free

Pökkun: í 25kgs trefjum trommur

Geymsla: Geymist óopnuð í köldum, þurrum stað, halda í burtu frá sterku ljósi

Geymsluþol: 24 mánuðir frá dagsetningu framleiðslu

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

virka:

1.Oleanolic sýru er tiltölulega ekki eitrað, antitumor, og hepatoprotective, auk sýna veirueyðandi verkun.
2.Oleanolic sýru var komist að sýna sterka and-HIV virkni.
3.Oleanolic sýru er stórt verndari kúvettum miðað við oxun og rafsæki streitu.
4.Oleanolic sýra hefur mikil áhrif á andi efnasamsetningu veira lifrarbólga, bráð icteric lifrarbólgu og langvinna lifrarbólgu.
Umsókn:
1. Applied á sviði matvæla, getur það virkar eins og hráefni te til að draga úr phlegm;
2. Applied á sviði lyfja, verður það er ný lyf gegn krabba með lág eitrað;
3. Applied í snyrtivörur sviði, það getur lífga blóðrásina og fjarlægja drykkur.