Oleanolic Acid Powder

センブリのリンドウ科の植物から単離された3五の環トリテルペノイドであるオレアノール酸は、多くの植物中のフリー体と配糖体で、全草またはイボタノキの果実をmileensis。 オレアノール酸は、植物中に広い範囲を有し、そして平均含有量は0.2％であり、 - 2％。 ウリ科の高い含有量は、0.6％〜0.7％.Oleanolic酸のイボタノキ果実含量属キク科、Syzygiumシルベストリス、またはトウネズミモチの果実から単離された五トリテルペノイド化合物の種類1.5％〜せむしの底は2％です。 これは、アジュバントおよび臨床治療感染に用い、肝疾患です。 急性黄疸型肝炎は、アラニンアミノトランスフェラーゼとyellowing.Oolic酸の削減に明らかな効果を持っているセンブリのキネンシスまたはフルクタスの果実から分離五環トリテルペンは、リンドウ科植物からligustrisです。 オレアノール酸が広く、0.2％〜2％の[1]の一般的な内容で、植物に見出されます。 ひょうたんの底部の含有量は約2％~1.5％であり、フルクタスligustrisの果実の含有量が0.7％〜0.6％でした。 オレアノール酸を白色針状結晶（エタノール）、無臭、無味です。 酸および塩基に不安定。 ℃308〜310の融点、[アルファ] 20 D + 73.3°（c = 0.15、クロロホルム、水に不溶、メタノールに可溶、エタノール、エチルエーテル、アセトン及びchloroform.Oleanolic酸が広く分布し、天然に存在するトリテルペノイドであります食品及び薬用植物で、ベツリン酸に関連する。これは、ヨウシュヤマゴボウ（アメリカヤマゴボウ）に見出すことができ、Syzygium属、ニンニク、等、比較的非毒性であり、肝臓保護、及び展示抗腫瘍及び抗ウイルス特性。
れたオレアノール酸、強力な抗HIV活性を示すことが判明し、関連化合物ベツリン酸は、最初の商用成熟阻害薬を作成するために使用された。これは、最初ローザwoodsii（葉）を含むいくつかの植物、から学び、単離された、Prosopis glandulosa（葉や小枝） Phordendronのjuniperinum（全草）、Syzygiumのclaviflorum（葉）、Hyptisのcapitata（全草）、およびTernstromiaのgymnanthera（地上部）。Javaのリンゴを含む他のSyzygium種（レンブ）とリンゴをバラ sが、それが含まれています。

製品名：オレアノール酸 98 ％

仕様：98％HPLCによる

植物出典：オレアのEuropeaのエキス

化学名：（3β）-3- Hydroxyolean-12-JA-28オイック酸

CAS番号：508-02-1

リーフ：使用パート

カラー：特有の匂いと味を持つ白色粉末

GMOステータス：GMOフリー

パッキング：25kgsファイバードラムに

ストレージ：強い光から遠ざけること、涼しい、乾燥した場所に未開封の容器を保管してください

賞味期限：製造日から24ヶ月

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

関数：

1.Oleanolic酸は比較的非毒性であり、抗腫瘍、及び肝臓保護、ならびに抗ウイルス特性を示します。
2.Oleanolic酸は強力な抗HIV活性を示すことが分かりました。
3.Oleanolic酸は酸化および求電子ストレスに対する細胞の主要なプロテクターです。
4.Oleanolic酸は、ウイルス性肝炎、急性黄疸型肝炎と慢性肝炎をtratingに大きな効果があります。
応用：
食品分野での応用1.、それは痰を減らすために、茶の原料として機能することができます。
医薬分野での応用2.、それは低い毒性を持つ新しい抗がん剤となり、
化粧品分野での応用3。は、それが血液の循環を活性化し、飲料を削除することができます。