Oleanolic Acid Powder

Oleanolzuur dat een drie pentacyclische triterpenoids geïsoleerd uit planten Gentianaceae van Swertia mileensis geheel gras of liguster vruchten, met een vrij lichaam en glycosiden in vele planten. Oleanolzuur heeft een breed scala van planten en het gemiddelde gehalte 0,2% - 2%. Cucurbitaceae hoog gehalte 1,5% ~ bochel bodem 2%, liguster vruchten van 0,6% -0,7% .Oleanolic zuur een soort pentacyclische triterpenoid verbinding geïsoleerd uit de vruchten van het geslacht Asteraceae, Syzygium sylvestris of Ligustrum lucidum. Het is een leverziekte adjuvans en klinisch gebruikt voor therapeutische infectie. Acute hepatitis geelzucht heeft duidelijke gevolgen op het verminderen van alanine aminotransferase en yellowing.Oolic zuur een pentacyclische triterpenoids geïsoleerd uit de vrucht van Swertia chinensis of fructus ligustris de Gentianaceae plant. Oleanolzuur wordt algemeen gevonden in planten, met een algemene gehalte van 0,2% -2% [1]. Het gehalte aan onderzijde van kalebas 1,5% -2%, en het gehalte aan vrucht fructus ligustris 0,6% ~ 0,7%. Oleanolzuur wit naaldvormig kristal (ethanol), reukloos en smaakloos. Onstabiel zuren en basen. Smeltpunt 308 ~ 310 ℃, [a] 20D + 73,3 ° (c = 0,15, chloroform, onoplosbaar in water, oplosbaar in methanol, ethanol, ethylether, aceton en chloroform.Oleanolic zuur een natuurlijk voorkomend triterpenoïde, wijdverspreid voedsel- en medicinale planten, in verband met betulinezuur. Het ligt in Phytolacca americana (Amerikaanse karmozijnbes) en Syzygium spp, knoflook, etc. Het is niet giftig, hepatoprotectieve en tentoonstellingen antitumor en antivirale eigenschappen.
oleanolinezuur was gevonden sterke anti-HIV activiteit vertonen, werd de verwante verbinding betulinezuur gebruikt om het eerste commerciële rijping inhibitor geneesmiddel te maken. het werd eerst bestudeerd en geïsoleerd uit verschillende planten, waaronder Rosa woodsii (bladeren), Prosopis glandulosa (bladeren en twijgen), Phordendron juniperinum (hele plant), Syzygium claviflorum (bladeren), Hyptis capitata (hele plant), en Ternstromia gymnanthera (antenne deel). Andere Syzygium soorten, waaronder java apple (Djamboe semarang) en djamboevrucht s indammen.

Naam product: oleanolzuur  98 %

Specificatie: 98% volgens HPLC

Botanische Bron: Olea Europea Extract

Chemische naam: (3β) -3-Hydroxyolean-12-en-28-zuur

CAS No: 508-02-1

Gebruikt deel: Blad

Kleur: Wit poeder met kenmerkende geur en smaak

GMO Status: Vrij GMO

Verpakking: in 25kg kartonnen vaten

Opslag: Container ongeopend in een koele, droge plaats, uit de buurt houden van sterke licht

Houdbaarheid: 24 maanden vanaf de datum van productie

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Functie:

1.Oleanolic zuur relatief niet-toxisch, antitumor en hepatoprotectief, en vertonen antivirale eigenschappen.
2.Oleanolic zuur bleek sterke anti-HIV activiteit vertonen.
3.Oleanolic zuur is een belangrijke beschermer van cellen tegen oxidatieve en elektrofiel stress.
4.Oleanolic zuur groot effect op trating virus hepatitis, acute hepatitis icterische en chronische hepatitis.
Toepassing:
1. Toegepast in voedsel gebied, kan het fungeert als grondstoffen van thee om slijm te verminderen;
2. Toegepast op farmaceutisch gebied, wordt een nieuwe anti-kanker geneesmiddel met lage giftig;
3. Toegepast in cosmetische gebied, kan het de bloedcirculatie stimuleren en te verwijderen drank.