Wholesale Oleanolic Acid powder manufacturers and suppliers | Tong Rui Bio-Tech

Oleanolic Acid Powder

Pfupi Tsananguro:

Oleanolic asidhi kwakawanikwa kuratidza simba Anti-HIV basa, anoenderana mukomboni betulinic asidhi rakashandiswa kusika yokutanga vezvokutengeserana kuibvisa inhibitor zvinodhaka. Wakatanga vakadzidza uye kure miti wandei, kusanganisira Rosa woodsii (mashizha), Prosopis glandulosa (mashizha uye manyoro), Phordendron juniperinum (rose chirimwa), Syzygium claviflorum (mashizha), Hyptis capitata (rose chirimwa), uye Ternstromia gymnanthera (zvemuchadenga chikamu). Other Syzygium marudzi kusanganisira Java apuro (Syzygium samarangense) uye akamuka maapuro ane izvozvo.


  • Mutengo weFOB: US $0.5 - 2000 / KG
  • Min.Order Kuwanda: 1 KG
  • Supply Mano: 10000 KG / pamwedzi
  • Port: Shanghai / Beijing
  • Mitemo Yekubhadhara: L / C, D / A, D / P, T / T
  • :
  • Chigadzirwa Nhamba

    Chigadzirwa Matagi

    Oleanolic asidhi inova pentacyclic triterpenoids matatu kure Gentianaceae zvirimwa Swertia mileensis uswa kana privet yose michero, ine akasununguka muviri uye glycosides mune miti yakawanda. Oleanolic asidhi ane-siyana mune miti, uye avhareji zviri 0.2% - 2%. Cucurbitaceae mukuru zviri 1,5% ~ ane musana wakakombama pasi 2%, privet zvibereko zviri 0,6% ~ 0,7% .Oleanolic asidhi rudzi pentacyclic triterpenoid remubatanidzwa kure michero genus Asteraceae, Syzygium sylvestris, kana Ligustrum lucidum. Zviri adjuvant chiropa chirwere uye akaora kushandiswa kuchirapa chirwere. Chenjera jaundice chiropa ane migumisiro pachena pamusoro yokuderedza alanine aminotransferase uye yellowing.Oolic asidhi chinhu pentacyclic triterpenoids kure chibereko swertia chinensis arcuate kana fructus ligustris kubva gentianaceae chirimwa. Oleanolic asidhi zvinowanzodavirwa kuwanikwa zvinomera, ane vakawanda zviri 0.2% ~ 2% [1]. Zviri pasi dende rakanga 1,5% ~ 2%, uye zviri zvibereko fructus ligustris akanga 0,6% ~ 0,7%. Oleanolic asidhi iri chena acicular sekristaro (panyaya iyi), odorless uye shata. Kugadzikana kune acids uye zvigadziko. Kubvunda pfungwa 308 ~ 310 ℃, [Alpha] 20 D + 73.3 ° (c = 0,15, chloroform, insoluble nemvura, soluble mu methanol, panyaya iyi, ethyl neEteri, acetone uye chloroform.Oleanolic asidhi ari sezvingatarisirwa kuitika triterpenoid, rinoparadzirwa nezvokudya uye makwenzi, kufanana betulinic acid. rinogona kuwanikwa Phytolacca american (American pokeweed), uye Syzygium spp, gariki, etc. zviri yakati vasiri chepfu, hepatoprotective, uye Exhibits antitumor uye antiviral zvivako.
    Oleanolic asidhi yakanga ndikawana kuratidza simba Anti-HIV basa, anoenderana mukomboni betulinic asidhi rakashandiswa kusika yokutanga vezvokutengeserana kuibvisa inhibitor zvinodhaka. wakatanga vakadzidza uye kure miti wandei, kusanganisira Rosa woodsii (mashizha), Prosopis glandulosa (mashizha uye manyoro), Phordendron juniperinum (rose chirimwa), Syzygium claviflorum (mashizha), Hyptis capitata (rose chirimwa), uye Ternstromia gymnanthera (zvemuchadenga chikamu). Other Syzygium marudzi kusanganisira Java apuro (Syzygium samarangense) uye akamuka apuro S ane izvozvo.

     

    Product Name: Oleanolic acid  98 %

    Specification: 98% kubudikidza HPLC

    Botanic Source: Olea Europea kusvina

    Chemical Name: (3β) -3-Hydroxyolean-12-en-28-oic asidhi

    CAS No: 508-02-1

    Chikamu Used: Leaf

    Color: White upfu pamwe mamirire kwakanaka uye kuravira

    GMO Status: GMO Free

    Apex muna 25kgs faibha ngoma

    Storage: Rambai mudziyo unopened kuchitonhora, panzvimbo yakaoma, Rambai kure chiedza simba

    Pasherufu Life: 24 mwedzi kubva musi okuwana

     

    What is oleanolic acid?

    Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

    Oleanolic acid structure

    Where can you find oleanolic acid?

    Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

    Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

    oleanolic acid sources

    Herb Name Oleanolic acid content Test method
    Ligustrum lucidum Ait 0.8028% HPLC
    Verbena Officinalis L 0.071%-0.086% HPLC
    Prunella vulgaris L 3.47%-4.46% HPLC
    Hemsley Chinensis Cogn. 1.5%~2% HPLC

    Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

    Hemsley Chinensis Cogn. Introduction

    Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

    Familia: Cucurbitaceae

    Tribus: Gomphogyneae

    Genus: Hemsleya

    Species: H. amabilis

    The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

    Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

    Medicinal Values:

    Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

    Hemsleya chinensis Cogn

    Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

    Oleanolic acid manufacturing

    Formulas containing Oleanolic acid in Food supplements

    We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

    • Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
    • Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
    • Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

    Oleanolic acid FORMULA

    Oleanolic acid VS Ursolic acid

    Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

    These triterpenoids compounds are known to exist in medicinal herbs and foods.

    They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

    Oleanolic acid VS Ursolic acid comparison

    OA and UA difference:

    Product Name Oleanolic acid Ursolic acid
    CAS NO. 508-02-1 77-52-1
    Pentacyclic triterpenes  β-Amyrin α-Amyrin
    Herb sources Loquat leaf, Holy Basil, Rosemary, Olive leaf.etc.
    Specifications 40%,98%powder 15%,25%,50%,98%powder
    Appearance(color and odor) 40% light yellow98%white powderodorless 15%-50% brown-yellow or yellow98%white powderCharacteristic
    Distinguishing IR:(1355~1392cm-1) two peaks(1245~1330cm-1) three peaksNMR:δ(C12)122.1,δ(C13)143.4 (1355~1392cm-1) three peaks(1245~1330cm-1) three peaksδ(C12)125.5,δ(C13)138.0
    Derivatives Oleanolic sodium saltOleanolic acid phosphate disodium salt3-oxo oleanolic acid

    bardoxolone methyl (CDDO-Me)

    Ursolic sodium salt and its dicarboxylic acid half ester derivativesUrsolic acid ketene derivatives3-carbon ursolic acid

    3-acetoxyursolic acid

    Potential anticancer UA is more popular than OA.

    Biological Activities of Oleanolic Acid

    1. Anti-Tumour/Anti-Cancer Effects

    Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

     – by Xin Wang, Hua Bai, etc. Researchers

    OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

    OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

    OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

    OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

    In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

    Oleanolic Acid benefits

    1. Antimicrobial Activity

    OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

    OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

    1. Hepatoprotective Ability

    One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

    In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

    Oleanolic Acid and its derivatives

    Oleanolic Acid and its derivatives

    Oleanolic Acid Clinical Trials

    Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

    Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

     

    Chinese Pharmacopoeia Standard of Oleanolic Acid

    Product zita Oleanolic Acid
    kuongorora (1)Take 30mg of this product, put it in a test tube, add 3ml of chloroform to dissolve, add two drops of sulfuric acid, shake for 5 minutes, the chloroform layer is purple-red.
    (2)Take about 20mg of this product, add 1ml of acetic anhydride, dissolve it with a slight heat, add sulfuric acid to the purple color, and darken after placing.
    (3)Take about 10mg of this product, add vanillin glacial acetic acid solution (take vanillin 0.5g, add 10ml of glacial acetic acid to dissolve, that is) 0.2ml, add 0.8ml of perchloric acid, and heat it for several minutes in a water bath. Fuchsia, add 2ml of ethyl acetate, purple-red dissolved in ethyl acetate, placed without discoloration.
    (4)The infrared absorption spectrum of this product should be consistent with the control spectrum.
    Determination of assay Take 0.15g of this product, accurately weigh it, add 30ml of ethanol, shake it, heat it in a warm water bath to dissolve, let cool to room temperature, add 3 drops of phenolphthalein indicator solution, make potassium hydroxide solution with ethanol (0.05mol/L) Titrate immediately and correct for blank test. Potassium hydroxide solution (0.05 mol/L) per 1 ml of ethanol corresponds to 22.84 mg of C30H 48O 3.

    Oleanolic acid recommend dosage

    According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

    Oleanolic acid side effects

    Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

    If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

    Please consult your physician or pharmacist before using this product.

    basa:

    1.Oleanolic asidhi achiri vasiri chepfu, antitumor, uye hepatoprotective, uyewo nedzokunze antiviral ehupfumi.
    2.Oleanolic asidhi kwakawanikwa kuratidza simba Anti-HIV basa.
    3.Oleanolic asidhi chikuru mudziviriri masero pamusoro oxidative uye electrophile mupfungwa.
    4.Oleanolic asidhi ane mugumisiro trating utachiona chiropa, chenjera icteric kuzvimba chiropa uye chisingaperi chiropa.
    Application:
    1. kushandiswa munda zvokudya, unogona anoita se mbishi zvinhu yetii kuderedza phlegm;
    2. kushandiswa mishonga munda, inova chitsva Anti-kenza zvinodhaka pamwe kuchamudukupisa chepfu;
    3. kushandiswa munda zvizorwa, rinogona Dzinoshingisa ropa kuparadzirwa uye vobvisa chinwiwa.

     

     

     

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