Oleanolic Acid Powder

Àcitu Oleanolic chì hè una di trè triterpenoids pentacyclic isolé da i pianti Gentianaceae di Swertia mileensis u friscalette, erba, o privet frutta, cù un corpu senza e glycosides in parechji pianti. Àcitu Oleanolic hà una larga gamma in i pianti, è u cuntenutu mediu hè 0,2% - 2%. Cucurbitaceae altu cuntenutu hè 1,5% ~ bossu funnu 2%, privet cuntenutu fruttu di 0.6% ~ à 0,7% .Oleanolic àcitu hè un tipu d 'cumposta triterpenoid pentacyclic isolé da u fruttu di u genaru Asteraceae, Syzygium sylvestris, o Ligustrum lucidum. Hè una adjuvants k fegato è clinically usatu pi Ciak therapeutic. Acutu ja jaundice hepatitis hà effetti chiaru su riducendu aminotransferase alanine è àcitu yellowing.Oolic hè una triterpenoids pentacyclic isolé da u fruttu di u chinensis swertia o fructus ligustris da u pianta gentianaceae. Àcitu Oleanolic hè ricunnisciuta trova in i pianti, cù un cuntinutu generale di 0,2% ~ 2% [1]. U cuntenutu di fondu di cushaw hè 1,5% ~ 2%, è u cuntenutu di frutta, di ligustris fructus hè 0.6% ~ à 0,7%. Àcitu Oleanolic hè cristal biancu acicular (etanolu), fragrant è tasteless. Nstabbili a filet e basi. Puntu di 308 ~ 310 Melting ℃, [alfa] 20 D + 73.3 ° (c = 0,15, Cristianèsimu, insoluble francese in acqua, sulùbbili in metano, etanolu, ethyl ether, acetone è àcitu chloroform.Oleanolic hè un triterpenoid maiò naturalmente, largamenti distribuitu in pastu e midicinali, piante, riguardanti àcitu betulinic. si pò trova in Phytolacca cunicularia (pokeweed American), è Syzygium spp, agliu, etc. hè abbastanza tossica, hepatoprotective, è percorsu antitumor è proprietà di antiviral.
àcitu Oleanolic hè truvò à vede forti attività anti-HIV, l 'àcitu betulinic cumposti ligata statu usatu pi criari lu primu Drug inhibitor vinificazioni cummirciali. hè stata a prima studiatu e isolé da parechji pianti, com'è Rosa woodsii (foglie), Prosopis glandulosa (foglie e nudeddi), Phordendron juniperinum (tutta a pianta), Syzygium claviflorum (foglie), Hyptis var capitata (tutta a pianta), è Ternstromia gymnanthera (parte cartes). Altri razze Syzygium cumpresi Java mela (Syzygium samarangense) e la rosa, mela di cuntena lu.

Name Product: Acid Oleanolic  98 %

Spicifichi: 98% da HPLC

Botanic Source: Ricacciatu Olea européenne

Name chimica: (3β) -3-Hydroxyolean-12-en-28-oic àcitu

CAS No: 508-02-1

Part Agriculture: foglia

Culore: marmura White cu ciauru caratteriseghjanu e gustu

GMO Status: GMO Free

Luigi: in 25kgs tamburi fibre

Storage: Cecceccu saccu unopened in arrizzà locu, asciuttu, Lascià luntanu da forti di luce

Cuttuni Life: 24 mesi da a data di pruduzzione

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

funzione:

Àcitu 1.Oleanolic hè abbastanza tossica, antitumor, è hepatoprotective, oltri exhibiting proprietà antiviral.
Àcitu 2.Oleanolic statu trovu à vede forti attività anti-HIV.
Àcitu 3.Oleanolic hè una primura prutitturi di Leoni contr'à oxidative e ddoi at electrophile.
Àcitu 4.Oleanolic hà gran effettu nant'à trating hepatitis Linguistic, hepatitis icteric fini è hepatitis yer.
Scrizzione:
1. Applied in campu di manciari, si pò mette cum'è materia prima di tè, à muti carma;
2. Applied in campu farmacia, addiventa un novu Drug anti-cancru cun suttana Aventura;
3. Applied in campu di cusmetichi, si pò invigorate circulazioni, sangue è caccià miste.