Wholesale Oleanolic Acid powder manufacturers and suppliers | Tong Rui Bio-Tech

Oleanolic Acid Powder

Kufotokozera Mwachidule:

asidi Oleanolic anapezeka kuti aonetse amphamvu ntchito odana ndi HIV, zokhudza pawiri asidi betulinic anamugwiritsa ntchito kulenga woyamba malonda kusasitsa woletsa mankhwala. Choyamba kuphunzira ndi olekanitsidwa zomera zosiyanasiyana, kuphatikizapo Rosa woodsii (masamba), Prosopis glandulosa (masamba ndi nthambi), Phordendron juniperinum (mmela wonse), Syzygium claviflorum (masamba), Hyptis capitata (mmela wonse), ndipo Ternstromia gymnanthera (mlengalenga gawo). Syzygium mitundu ina kuphatikizapo Java apulo (Syzygium samarangense) ndipo anauka maapulo ali izo.


  • Mtengo wa FOB: US $0.5 - 2000 / KG
  • Min.Order Kuchuluka: 1 KG
  • Wonjezerani Luso: 10000 KG / pamwezi
  • Doko: Shanghai / Beijing
  • Terms malipiro: L / C, D / A, D / P, T / T
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  • mankhwala Mwatsatanetsatane

    Tags mankhwala

    Asidi Oleanolic omwe ndi atatu pentacyclic triterpenoids olekanitsidwa zomera Gentianaceae wa Swertia mileensis lonse udzu kapena privet zipatso, ndi thupi ufulu ndi glycosides zomera ambiri. Asidi Oleanolic ali osiyanasiyana zomera, ndi okhutira avareji 0.2% - 2%. Cucurbitaceae mkulu okhutira 1.5% ~ hunchback pansi 2%, privet zipatso zili 0,6% ~ 0,7% .Oleanolic asidi ndi mtundu wa pentacyclic triterpenoid pawiri olekanitsidwa chipatso cha mtundu Asteraceae, Syzygium sylvestris, kapena Ligustrum lucidum. Ndi chiwindi matenda adjuvant ndi kukomoka ntchito matenda achire. Pachimake matenda a chikasu ndiyo chiwindi mavuto zoonekeratu pa kuchepetsa alanine aminotransferase acid yellowing.Oolic ndi triterpenoids pentacyclic olekanitsidwa chipatso cha swertia chinensis kapena fructus ligustris ndi zomera gentianaceae. Asidi Oleanolic chimagwiritsidwa anapeza zomera, ndi wokhutira ambiri 0.2% ~ 2% [1]. The zili pansi Chikho anali 1.5% ~ 2%, ndipo zili zipatso za ligustris fructus anali 0,6% ~ 0,7%. Asidi Oleanolic ndi woyera acicular galasi (Mowa), odorless ndi zoipa. Kusakhazikika kwa zidulo ndi zapansi. Kusungunuka kufika 308 ~ 310 ℃, [Alpha] 20 D + 73.3 ° (c = 0,15, chloroform, insoluble m'madzi, sungunuka methanol, Mowa, ethyl efa, acetone ndi chloroform.Oleanolic asidi ndi triterpenoid mwachibadwa zikuchitika, inafalitsidwa chakudya ndi mankhwala zomera, zokhudzana ndi asidi betulinic. Iwo angapezeke mu Phytolacca Americana (American pokeweed), ndipo Syzygium spp, adyo, etc. ndi ndi sanali poizoni, hepatoprotective, ndi zinaonetsedwa pa chionetserocho antitumor ndi katundu mavairasi oyambitsa.
    asidi Oleanolic anali anapeza kuti aonetse amphamvu ntchito odana ndi HIV, zokhudza pawiri asidi betulinic anamugwiritsa ntchito kulenga woyamba malonda kusasitsa woletsa mankhwala choyamba kuphunzira ndi olekanitsidwa zomera zosiyanasiyana, kuphatikizapo Rosa woodsii (masamba), Prosopis glandulosa (masamba ndi nthambi). Phordendron juniperinum (mmela wonse), Syzygium claviflorum (masamba), Hyptis capitata (mmela wonse), ndipo Ternstromia gymnanthera (mlengalenga mbali). Syzygium mitundu ina kuphatikizapo Java apulo (Syzygium samarangense) ndipo anauka apulo m ali izo.

     

    Dzina mankhwala: Oleanolic Acid  98 %

    Mfundo: 98% ndi HPLC

    Botanic Source: Olea Europea Tingafinye

    Mankhwala Dzina: (3β) -3-Hydroxyolean-12-en-28-oic asidi

    CAS No: 508-02-1

    Part Ntchito: Leaf

    Mtundu: White ufa ndi fungo khalidwe ndi kukoma

    GMO Momwe: GMO Free

    Wazolongedza: mu 25kgs CHIKWANGWANI ng'oma

    Yosungirako: Khalani chidebe osatsegulidwa ozizira, youma, Khalani kutali ndi kuwala amphamvu

    Alumali Moyo: miyezi 24 kuchokera tsiku kupanga

     

    What is oleanolic acid?

    Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

    Oleanolic acid structure

    Where can you find oleanolic acid?

    Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

    Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

    oleanolic acid sources

    Herb Name Oleanolic acid content Test method
    Ligustrum lucidum Ait 0.8028% HPLC
    Verbena Officinalis L 0.071%-0.086% HPLC
    Prunella vulgaris L 3.47%-4.46% HPLC
    Hemsley Chinensis Cogn. 1.5%~2% HPLC

    Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

    Hemsley Chinensis Cogn. Introduction

    Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

    Familia: Cucurbitaceae

    Tribus: Gomphogyneae

    Genus: Hemsleya

    Species: H. amabilis

    The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

    Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

    Medicinal Values:

    Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

    Hemsleya chinensis Cogn

    Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

    Oleanolic acid manufacturing

    Formulas containing Oleanolic acid in Food supplements

    We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

    • Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
    • Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
    • Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

    Oleanolic acid FORMULA

    Oleanolic acid VS Ursolic acid

    Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

    These triterpenoids compounds are known to exist in medicinal herbs and foods.

    They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

    Oleanolic acid VS Ursolic acid comparison

    OA and UA difference:

    Mankhwala Dzina Oleanolic acid Ursolic acid
    CAS NO. 508-02-1 77-52-1
    Pentacyclic triterpenes  β-Amyrin α-Amyrin
    Herb sources Loquat leaf, Holy Basil, Rosemary, Olive leaf.etc.
    Specifications 40%,98%powder 15%,25%,50%,98%powder
    Appearance(color and odor) 40% light yellow98%white powderodorless 15%-50% brown-yellow or yellow98%white powderCharacteristic
    Distinguishing IR:(1355~1392cm-1) two peaks(1245~1330cm-1) three peaksNMR:δ(C12)122.1,δ(C13)143.4 (1355~1392cm-1) three peaks(1245~1330cm-1) three peaksδ(C12)125.5,δ(C13)138.0
    Derivatives Oleanolic sodium saltOleanolic acid phosphate disodium salt3-oxo oleanolic acid

    bardoxolone methyl (CDDO-Me)

    Ursolic sodium salt and its dicarboxylic acid half ester derivativesUrsolic acid ketene derivatives3-carbon ursolic acid

    3-acetoxyursolic acid

    Potential anticancer UA is more popular than OA.

    Biological Activities of Oleanolic Acid

    1. Anti-Tumour/Anti-Cancer Effects

    Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

     – by Xin Wang, Hua Bai, etc. Researchers

    OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

    OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

    OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

    OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

    In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

    Oleanolic Acid benefits

    1. Antimicrobial Activity

    OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

    OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

    1. Hepatoprotective Ability

    One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

    In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

    Oleanolic Acid and its derivatives

    Oleanolic Acid and its derivatives

    Oleanolic Acid Clinical Trials

    Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

    Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

     

    Chinese Pharmacopoeia Standard of Oleanolic Acid

    Dzina mankhwala Oleanolic Acid
    Chiphaso (1)Take 30mg of this product, put it in a test tube, add 3ml of chloroform to dissolve, add two drops of sulfuric acid, shake for 5 minutes, the chloroform layer is purple-red.
    (2)Take about 20mg of this product, add 1ml of acetic anhydride, dissolve it with a slight heat, add sulfuric acid to the purple color, and darken after placing.
    (3)Take about 10mg of this product, add vanillin glacial acetic acid solution (take vanillin 0.5g, add 10ml of glacial acetic acid to dissolve, that is) 0.2ml, add 0.8ml of perchloric acid, and heat it for several minutes in a water bath. Fuchsia, add 2ml of ethyl acetate, purple-red dissolved in ethyl acetate, placed without discoloration.
    (4)The infrared absorption spectrum of this product should be consistent with the control spectrum.
    Determination of assay Take 0.15g of this product, accurately weigh it, add 30ml of ethanol, shake it, heat it in a warm water bath to dissolve, let cool to room temperature, add 3 drops of phenolphthalein indicator solution, make potassium hydroxide solution with ethanol (0.05mol/L) Titrate immediately and correct for blank test. Potassium hydroxide solution (0.05 mol/L) per 1 ml of ethanol corresponds to 22.84 mg of C30H 48O 3.

    Oleanolic acid recommend dosage

    According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

    Oleanolic acid side effects

    Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

    If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

    Please consult your physician or pharmacist before using this product.

    ntchito:

    Asidi 1.Oleanolic zimakhalanso sanali poizoni, antitumor, ndi hepatoprotective, komanso naonetsere katundu mavairasi oyambitsa.
    Asidi 2.Oleanolic anapezeka kuti aonetse amphamvu ntchito odana ndi HIV.
    Asidi 3.Oleanolic ndi mtetezi yaikulu ya maselo ndi zobwera chifukwa cha okosijeni ndi nkhawa electrophile.
    Asidi 4.Oleanolic ali phindu trating HIV chiwindi, pachimake icteric chiwindi ndi chiwindi aakulu.
    ntchito:
    1. Ntchito m'munda chakudya, chitha amachita ngati zipangizo ya tiyi kuchepetsa phlegm;
    2. Ntchito m'munda mankhwala, izo zakhala zatsopano odana ndi khansa mankhwala ndi poizoni wochepa;
    3. Ntchito m'munda zodzikongoletsera, izo kungatilimbitse magazi ndi kuchotsa chakumwa.

     

     

     

    Zambiri za TRB

    lamulo chitsimikizo
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    Pafupifupi zaka 20, katundu m'mayiko 40 ndipo m'madera oposa 2000 magulu umatulutsa TRB alibe vuto lililonse quality, wapadera ndondomeko kuyeretsedwa uchimo ndi ulamuliro chiyero kudzakhalire USP, EP ndi CP
    Mabuku Quality System

     

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    Amphamvu Mabungwe Cooperative kuthandiza
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