Oleanolic Acid Powder

Oleanolic iasidi leyo triterpenoids ezintathu pentacyclic ingadibani kwizityalo Gentianaceae of Swertia mileensis lonke ingca okanye privet iziqhamo, kunye nomzimba simahla kunye glycosides izityalo ezininzi. Oleanolic acid enoluhlu olubanzi izityalo, kwaye umxholo umlinganiselo 0.2% - 2%. Umxholo eliphezulu Cucurbitaceae yi-1.5% ~ unqaphele ezantsi-2%, privet isiqulatho isiqhamo 0.6% ~ 0.7% .Oleanolic acid i uhlobo pentacyclic compound triterpenoid uyazimela kwisiqhamo sodidi kanti elithi, Syzygium sylvestris, okanye Ligustrum lucidum. It is a adjuvant isifo isibindi kwaye zisetyenziswa ngokwezonyango losuleleko therapeutic. Acute senyongo hepatitis lineziphumo ezicacileyo ekunciphiseni aminotransferase alanine kwaye yellowing.Oolic acid i triterpenoids pentacyclic uyazimela isiqhamo swertia chinensis okanye fructus ligustris ukusuka kwisityalo gentianaceae. Oleanolic acid lusengelwa ifumaneka kwizityalo, ezinomthamo jikelele ye 0.2% ~ 2% [1]. Umxholo we ezantsi igula, yaba 1.5% ~ 2%, kunye nomxholo zeziqhamo ligustris fructus yaba 0.6% ~ 0.7%. Oleanolic asidi crystal omhlophe acicular (ethanol), esha nasongo. Uxhaphazelayo ukuba asidi kunye neziseko. Linabantu point of 308 ~ 310 ℃, [Alpha] 20 d + 73.3 ° (c = 0,15, chloroform, ezingenakunyibilika emanzini, enyibilikayo methanol, ethanol, ethyl iEtere, acetone kunye chloroform.Oleanolic iasidi a triterpenoid zisenzeka ngokwendalo, kabanzi ngokutya kunye nokunyanga izityalo, ezinxulumene betulinic acid. Izakufunyanwa kwi Phytolacca Americana (pokeweed American), kunye Syzygium spp, igalikhi, njl Kubiza non-ezingenabungozi, hepatoprotective, yaye imiboniso antitumor kunye neempawu antiviral.
Oleanolic asidi Akufumanekanga ukubonisa umsebenzi onamandla anti-HIV, i-compound ezinxulumene betulinic acid yasetyenziswa ukudala ashishinayo ichiza ekukhuleni inhibitor yokuqala. ekuqaleni bafunda kwaye ingadibani izityalo eziliqela, kuquka Rosa woodsii (amagqabi), Prosopis glandulosa (amagqabi kunye amasetyana), Phordendron juniperinum (isityalo uphela), Syzygium claviflorum (amagqabi), Hyptis capitata (isityalo uphela), kunye Ternstromia gymnanthera (inxalenye eriyeli). Ezinye iintlobo Syzygium kuquka java iapile (Syzygium samarangense) kunye wavuka apile s aligcine.

Igama Product: Oleanolic Acid  98 %

Ingcaciso: 98% ngo solibalo

Botanic Umthombo: Olea Europea Extract

Chemical Name: (3β) -3-Hydroxyolean-12-en-28-oic acid

CAS No: 508-02-1

Icandelo Used: Igqabi

Umbala: powder White kunye livumba iimpawu kunye nemvakalo

YeMfuzo Ubume: yeMfuzo Free

Ukupakisha: ngo 25kgs imigqomo ifayibha

Storage: Gcina isikhongozeli bengawatyi apha, kwindawo eyomileyo epholileyo, Gcina kude wokukhanya onamandla

Ubude bethuba Life: iinyanga ezingama-24 ukususela kumhla yemveliso

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

umsebenzi:

1.Oleanolic acid is non-zinetyhefu kakhulu, antitumor, kwaye hepatoprotective, kwakunye zibonise iipropati antiviral.
2.Oleanolic acid kwafunyaniswa ukuba ukubonisa umsebenzi onamandla anti-HIV.
3.Oleanolic acid kuyinto uMkhuseli ezinkulu zeeseli nxamnye oxidative noxinezeleko electrophile.
4.Oleanolic acid lube nempembelelo entle trating kohlobo, hepatitis etsolo icteric kunye kohlobo.
isicelo:
1. Applied intsimi ukutya, ungakwazi lisebenza izinto leti ukunciphisa phlegm;
2. Applied intsimi zamachiza, iba sisiyobisi anti-umhlaza entsha ezinetyhefu eliphantsi;
3. Applied intsimi izithambiso, oko kuvuselela kwegazi uze ususe neziselo.