Oleanolic Acid Powder

Кислотаи Oleanolic аст, ки се triterpenoids pentacyclic ҷудо аз растаниҳои Gentianaceae аз Swertia mileensis тамоми алаф ё privet мева, ки бо ҷисм ва glycosides озод дар бисёр нерӯгоҳҳои. Кислотаи Oleanolic дорои доираи васеи дар корхонаҳо, ва ба мундариҷаи ҳисоби миёна 0,2% - 2% аст. Cucurbitaceae мазмуни баланд аст 1.5% ~ Алёшаи поёни 2%, privet маводи мева 0,6% ~ 0,7% Кислотаи .Oleanolic як навъ мураккаб triterpenoid pentacyclic ҷудо аз меваи genus Asteraceae, Syzygium sylvestris, ё Ligustrum lucidum аст. Ин adjuvant бемории ҷигар аст ва барои сирояти clinically табобатї истифода бурда мешавад. Гепатити зардпарвин шадид дорад, таъсири маълум оид ба паст aminotransferase alanine ва кислотаи yellowing.Oolic аст triterpenoids pentacyclic ҷудо аз меваи chinensis swertia ё fructus ligustris аз ниҳол gentianaceae аст. Кислотаи Oleanolic аст, ба таври васеъ дар нерӯгоҳҳои бо мазмуни умумии 0,2% ~ 2% [1] пайдо. Мазмуни поёни calabash 1,5% ~ 2% буд, ва мазмуни меваи ligustris fructus 0,6% ~ 0,7% буд. Кислотаи Oleanolic булӯр сафед acicular (этилиро), бўй ва қувваташро аст. Ноустувор ба кислотаи ва пойгоҳҳои. Нуқтаи 308 ~ 310 Обшавии ℃, [алфа] 20 г + 73.3 ° (с = 0,15, chloroform, insoluble дар об, ҳалшаванда дар methanol, этилиро, спирти этилӣ ether, acetone ва кислотаи chloroform.Oleanolic аст triterpenoid табиатан рух, ба таври васеъ паҳн карда дар ғизо ва доруворї растаниҳо, вобаста ба кислотаи betulinic. Ин мумкин аст, дар Phytolacca амрикоӣ (pokeweed Амрико), ва spp Syzygium, сирпиёз ва ғайра пайдо Ин нисбатан ғайридавлатӣ заҳролуд аст, hepatoprotective, ва нигораҳои antitumor ва хосиятҳои антиретровирусї.
кислотаи Oleanolic шуд пайдо ба намоиш фаъолияти қавӣ зидди ВНМО, кислотаи betulinic мураккаб вобаста ба таъсиси аввалин тиҷоратӣ маводи мухаддир inhibitor maturation истифода бурда шуд. ин нахустин омўхта шуд ва ҷудо аз чанд растаниҳо, аз ҷумла, Роза woodsii (барг), Prosopis glandulosa (барг ва алафҳои), Phordendron juniperinum (тамоми ниҳол), Syzygium claviflorum (барг), Hyptis capitata (тамоми ниҳол), ва Ternstromia gymnanthera (қисми ҳавоӣ). Дигар намуди Syzygium аз ҷумла себ Java (Syzygium samarangense) ва бархоста себ и онро дар бар гирад.

Номи Маҳсулоти: Oleanolic кислотаи  98 %

Хусусиятҳои: 98% аз ҷониби HPLC

Botanic Манбаъ: иқтибос Olea Europea

Номи кимиёвии: (3β) -3-Hydroxyolean-12-En-28-СҲИ кислотаи

СКК Не: 508-02-1

Қисми Истифода бурда мешавад: барге

Ранги: хокаи сафед бо бӯи хос ва таъми

Статуси GMO: GMO Free

Бастабанди: дар 25kgs drums нахи

Гардероб: контейнер бакамолрасида дар сард, ҷои хушк нигоҳ доред, нигоҳ доред ва аз нури қавӣ

Муҳлати ҳаёт: 24 моҳ аз рӯзи истеҳсолот

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

вазифаи:

Кислотаи 1.Oleanolic нисбатан ғайридавлатӣ заҳролуд, antitumor, ва hepatoprotective, инчунин exhibiting хосиятҳои антиретровирусї аст.
Кислотаи 2.Oleanolic ба намоиш фаъолияти қавӣ зидди ВИЧ пайдо шуд.
Кислотаи 3.Oleanolic як корсозе асосии ҳуҷайраҳои зидди oxidative ва стресс electrophile аст.
Кислотаи 4.Oleanolic дорад, таъсири бузурге дар trating гепатити вируси гепатити шадиди icteric ва гепатити музмин.
Ариза:
1. додаи дар соҳаи озуқаворӣ, он метавонад ба сифати ашёи хом чой барои коҳиш додани phlegm амал мекунад;
2. додаи дар соҳаи дорусозӣ, аз он дар як маводи мухаддир зидди саратон нав кам заҳролуд мегардад;
3. додаи дар соҳаи косметикӣ, он метавонад гардиши хун Тақвияти ва хориҷ фарахбахш.