Oleanolic Acid Powder

Oleanolic acid uas yog ib tug peb pentacyclic triterpenoids cais los ntawm Gentianaceae cov nroj tsuag ntawm Swertia mileensis tag nrho cov nyom los yog privet txiv hmab txiv ntoo, nrog rau ib tug dawb lub cev thiab glycosides nyob rau hauv ntau cov nroj tsuag. Oleanolic acid muaj ib tug ntau yam nyob rau hauv cov nroj tsuag, thiab qhov nruab nrab cov ntsiab lus yog 0.2% - 2%. Cucurbitaceae siab cov ntsiab lus yog 1.5% ~ hunchback hauv qab 2%, privet txiv hmab txiv ntoo cov ntsiab lus ntawm 0.6% ~ 0.7% .Oleanolic acid yog ib yam ntawm cov pentacyclic triterpenoid compound cais los ntawm cov txiv hmab txiv ntoo ntawm cov genus Asteraceae, Syzygium sylvestris, los yog Ligustrum lucidum. Nws yog ib tug siab tus kab mob adjuvant thiab clinically siv rau kho kab mob. Mob mob daj ntseg kab mob siab muaj cuab los ntawm cov txo alanine aminotransferase thiab yellowing.Oolic acid yog ib tug pentacyclic triterpenoids cais los ntawm cov txiv hmab txiv ntoo ntawm swertia chinensis los yog Fructus ligustris los ntawm cov gentianaceae nroj tsuag. Oleanolic acid yog dav nyob rau hauv cov nroj tsuag, nrog rau ib tug general cov ntsiab lus ntawm 0.2% ~ 2% [1]. Cov ntsiab lus ntawm hauv qab ntawm calabash yog 1.5% ~ 2%, thiab cov ntsiab lus ntawm txiv hmab txiv ntoo ntawm Fructus ligustris yog 0.6% ~ 0.7%. Oleanolic acid yog dawb acicular siv lead ua (ethanol), ntxhiab thiab tasteless. Tsis ruaj tsis khov rau acids thiab bases. Melting point ntawm 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, chloroform, insoluble nyob rau hauv dej, soluble nyob rau hauv methanol, ethanol, ethyl ether, acetone thiab chloroform.Oleanolic acid yog ib tug lawm tab triterpenoid, dav faib nyob rau hauv cov zaub mov thiab lam nroj tsuag, hais txog betulinic acid. Nws muaj peev xwm yuav nrhiav tau nyob rau hauv Phytolacca americana (American pokeweed), thiab Syzygium spp, qij, etc. Nws yog tus uas tsis yog-tshuaj lom, hepatoprotective, thiab teev antitumor thiab antiviral zog.
Oleanolic acid yog pom kom muaj muaj zog anti-HIV kev ua si, lwm compound betulinic acid siv los mus tsim cov thawj coj mus muag maturation inhibitor tshuaj. Nws twb xub kawm thiab cais los ntawm ob peb nroj tsuag, nrog rau Rosa woodsii (nplooj), Prosopis glandulosa (nplooj thiab twigs), Phordendron juniperinum (tag nrho tsob nroj), Syzygium claviflorum (nplooj), Hyptis capitata (tag nrho tsob nroj), thiab Ternstromia gymnanthera (aerial ib feem). Lwm yam Syzygium hom xws li java Kua (Syzygium samarangense) thiab sawv Kua s muaj nws.

Khoom npe: Oleanolic Acid  98 %

Specification: 98% los ntawm HPLC

Botanic Source: Olea Europea Extract

Tshuaj Lub Npe: (3β) -3-Hydroxyolean-12-en-28-oic acid

CAS Tsis: 508-02-1

Part Siv: Nplooj

Xim: Dawb hmoov nrog cov yam ntxwv tsw thiab saj

GMO raws li txoj cai: GMO Dawb

Cov: nyob rau hauv 25kgs fiber drums

Cia: Khaws thawv uas tsis tau qheb nyob rau hauv txias, qhuav qhov chaw, Cia deb ntawm muaj zog teeb

Txee lub neej: 24 lub hlis ntawm hnub uas ntau lawm

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Function:

1.Oleanolic acid yog tus uas tsis yog-tshuaj lom, antitumor, thiab hepatoprotective, raws li zoo raws li seeb antiviral zog.
2.Oleanolic acid twb pom muaj muaj zog anti-HIV kev ua si.
3.Oleanolic acid yog ib qho loj protector ntawm hlwb tiv thaiv oxidative thiab electrophile kev nyuaj siab.
4.Oleanolic acid muaj kuj zoo kawg thiab nyob rau hauv trating tus kab mob no kab mob siab, mob icteric kab mob siab thiab mob kab mob siab.
Daim ntawv:
1. Applied nyob rau hauv cov zaub mov teb, nws tau ua raws li cov ntaub ntawv raw tshuaj yej los txo phlegm;
2. Applied nyob rau hauv kws teb, nws ua ib tug tshiab anti-cancer tshuaj nrog tsawg lom;
3. Applied nyob rau hauv kom hniav zoo nkauj teb, nws yuav invigorate ntshav thiab tshem tawm cov dej haus.