Oleanolic Acid Powder

Oleanolic asidra izay dia telo pentacyclic triterpenoids mitoka-monina avy any Gentianaceae zavamaniry ao Swertia mileensis manontolo privet bozaka na voankazo, miaraka amin'ny vatana sy glycosides malalaka amin'ny zavamaniry maro. Oleanolic asidra manana isan-karazany eo amin'ny zavamaniry, ary ny eo ho eo ny votoaty dia 0.2% - 2%. Cucurbitaceae afa-po avo dia 1.5% ~ hunchback ambany 2%, privet vokatry afa-po ny 0.6% ~ 0,7% .Oleanolic asidra dia karazana pentacyclic triterpenoid iombonana amin'ny mitoka-monina avy amin'ny vokatry ny karazana Asteraceae, Syzygium sylvestris, na Ligustrum lucidum. Izany dia aretina aty adjuvant ary clinically ampiasaina ho an'ny fitsaboana aretina. Matsilo jaundice mazava hépatite manana fiantraikany amin'ny fampihenana alanine aminotransferase sy yellowing.Oolic asidra dia pentacyclic triterpenoids mitoka-monina avy amin'ny vokatry ny swertia chinensis na fructus ligustris avy amin'ny gentianaceae fototra. Oleanolic be asidra no hita ao amin'ny zavamaniry, miaraka amin'ny ankapobeny afa-po ny 0.2% ~ 2% [1]. Ny afa-po ny ambany ny calabash dia 1.5% ~ 2%, sy ny afa-po amin'ny vokatry ny fructus ligustris dia 0.6% ~ 0,7%. Oleanolic asidra dia fotsy acicular krystaly (ethanol), odorless sy ny matsatso. Miovaova ny amine sy ny faladiany. Mitsonika fotoana ny 308 ~ 310 ℃, [Alfa] 20 D + 73.3 ° (c = 0,15, chloroform, Mora mampivaingana amin'ny rano, mety levona anaty methanol, ethanol, ethyl Etera, acétone sy chloroform.Oleanolic asidra dia iray voajanahary mitranga triterpenoid, miely amin'ny sakafo sy fanafody zavamaniry, mifandray amin'ny betulinic asidra. mety ho hita ao amin'ny Phytolacca Amerikanina (American pokeweed), sy Syzygium spp, tongolo gasy, sns izany dia somary tsy misy poizina, hepatoprotective, sy ny fampirantiana antitumor ary antiviral fananana.
Oleanolic asidra dia hita hanehoana mafy miady amin'ny VIH asa, ny mifandray iombonana betulinic asidra nampiasaina mba hamoronana ny voalohany ara-barotra maturation inhibitor zava-mahadomelina. nisy voalohany nianatra sy mitoka-monina avy amin'ny maro zavamaniry, anisan'izany Rosa woodsii (ravina), Prosopis glandulosa (ravina sy rantsankazo), Phordendron juniperinum (manontolo fototra), Syzygium claviflorum (ravina), Hyptis capitata (manontolo fototra), ary Ternstromia gymnanthera (an'habakabaka anjara). Syzygium hafa karazana paoma anisan'izany ny Java (Syzygium samarangense) sady efa nitsangana paoma S misy izany.

Product Name: Oleanolic Acid  98 %

Famaritana: 98% ny HPLC

Botanic Source: Olea Europea hanesorana

Simika Name: (3β) -3-Hydroxyolean-12-en-28-oic asidra

Čas No: 508-02-1

Fizarana Nampiasaina: Leaf

Color: White vovoka amin'ny fofona sy tsiro mampiavaka

GMO Status: GMO Free

Fonosana: in 25kgs fibre amponga

Fitehirizana: Ataovy fitoeran-javatra potsiny amin'ny mangatsiatsiaka, karankaina izy, Mitandrema ny amin'ny hazavana mahery

Talantalana Life: 24 volana avy amin'ny daty famokarana

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

asa:

1.Oleanolic asidra dia somary tsy misy poizina, antitumor, ary hepatoprotective, ary koa ny maneho antiviral fananana.
2.Oleanolic asidra hita mba hanehoana mafy anti-HIV asa.
3.Oleanolic asidra dia lehibe ny sela mpiaro manohitra oxidative sy electrophile adin-tsaina.
Be asidra 4.Oleanolic vokany eo amin'ny virosy niompana hepatita, Matsilo icteric hépatite sy ny mitaiza hepatita.
fampiharana:
1. ampiharina eo amin'ny sakafo an-tsaha, dia afaka miasa toy ny akora ny dite hampihenana phlegm;
2. Applied in fanafody saha, dia lasa ady amin'ny homamiadana vaovao amin'ny zava-mahadomelina ambany misy poizina;
3. Applied in tarehy an-tsaha, dia mety hanatanjaka fikorianan'ny ra sy hanala zava-pisotro.