Oleanolic Acid Powder

Asid oleanolic yang merupakan tiga triterpenoids pentasiklik diasingkan daripada tumbuhan Gentianaceae daripada Swertia mileensis rumput atau privet buah-buahan keseluruhan, dengan badan dan glikosida dalam banyak tumbuh-tumbuhan. Asid oleanolic mempunyai rangkaian hotel yang luas dalam tumbuh-tumbuhan, dan kandungan ialah 0.2% - 2%. Cucurbitaceae kandungan tinggi adalah 1.5% ~ bungkuk bawah 2%, kandungan buah privet 0.6% ~ 0.7% .Oleanolic asid adalah sejenis sebatian triterpenoid pentasiklik diasingkan dari buah genus Asteraceae, Syzygium sylvestris, atau Ligustrum lucidum. Ia adalah satu yg membantu penyakit hati dan klinikal digunakan untuk jangkitan terapeutik. Akut penyakit kuning hepatitis mempunyai kesan yang jelas kepada mengurangkan aminotransferase alanine dan asid yellowing.Oolic ialah triterpenoids pentasiklik diasingkan dari buah chinensis Swertia atau Fructus ligustris dari kilang Gentianaceae itu. Asid oleanolic secara meluas yang terdapat dalam tumbuhan, dengan kandungan umum 0.2% hingga 2% [1]. Kandungan bawah labu adalah 1.5% hingga 2%, dan kandungan buah ligustris Fructus ialah 0.6% ~ 0.7%. Asid oleanolic adalah kristal putih jejarum (ethanol), tidak berbau dan tanpa rasa. Tidak stabil asid dan bes. Takat lebur 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, kloroform, tidak larut dalam air, larut dalam metanol, etanol, eter, aseton dan asid chloroform.Oleanolic ialah triterpenoid yang berlaku secara semula jadi, diedarkan secara meluas dalam makanan dan ubat-ubatan tumbuh-tumbuhan, yang berkaitan dengan asid betulinic. Ia boleh didapati dalam Phytolacca americana (pokeweed Amerika), dan Syzygium spp, bawang putih, dan lain-lain Ia adalah bukan toksik, hepatoprotective dan penuh antitumor dan antivirus.
asid oleanolic adalah telah memperolehi untuk mempamerkan aktiviti anti-HIV kuat, asid betulinic kompaun berkaitan telah digunakan untuk mencipta ubat kematangan perencat komersial yang pertama. Ia mula dikaji dan diasingkan daripada beberapa tumbuhan, termasuk Rosa woodsii (daun), Prosopis glandulosa (daun dan ranting), Phordendron juniperinum (keseluruhan tumbuhan), Syzygium claviflorum (daun), Hyptis capitata (keseluruhan tumbuhan), dan Ternstromia gymnanthera (bahagian udara). spesies Syzygium lain termasuk java epal (jambu air) dan meningkat epal s membendungnya.

Nama produk: asid oleanolic  98 %

Spesifikasi: 98% oleh HPLC

Source Botanic: Ekstrak Olea Europea

Nama Kimia: (3β) -3-Hydroxyolean-12-en-28 OIC asid

CAS No: 508-02-1

Bahagian yang digunakan: Daun

Warna: serbuk putih dengan bau ciri dan rasa

GMO Status: GMO Percuma

Pembungkusan: dalam 25kgs gentian gendang

Penyimpanan: Simpan bekas yang belum dibuka di tempat yang sejuk, kering, Jauhkan daripada cahaya yang kuat

Jangka hayat: 24 bulan dari tarikh pengeluaran

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

fungsi:

Asid 1.Oleanolic adalah agak tidak toksik, antitumor, dan hepatoprotective, serta mempamerkan sifat antivirus.
Asid 2.Oleanolic didapati mempamerkan aktiviti anti-HIV yang kuat.
Asid 3.Oleanolic adalah pelindung utama sel-sel daripada pengoksidaan dan tekanan electrophile.
Asid 4.Oleanolic mempunyai kesan yang besar pada trating hepatitis virus, hepatitis icteric akut dan hepatitis kronik.
permohonan:
1. Gunaan dalam bidang makanan, ia boleh bertindak sebagai bahan-bahan mentah teh untuk mengurangkan kahak;
2. Gunaan dalam bidang farmaseutikal, ia menjadi ubat anti-kanser yang baru dengan rendah toksik;
3. Gunaan dalam bidang kosmetik, ia boleh menceriakan peredaran darah dan mengeluarkan minuman.