Oleanolic Acid Powder

Swertia ning Gentianaceae nabototlar izolyatsiya uch pentacyclic triterpenoids hisoblanadi Oleanolic kislotasi ko'p o'simliklarda erkin tana va glikozidlarini bilan, butun o't yoki Privet meva mileensis. Oleanolic kislotasi o'simliklarda keng va o'rtacha tarkibi 0,2% - 2%. Kabakgiller yuqori kontent 1,5% ~ bukur odam pastki 2%, 0,6% ~ 0,7% .Oleanolic kislotasi Privet meva tarkibi turdagi Asteraceae, Syzygium sylvestris yoki Ligustrum LUCIDUM sifatida mevalaridan yakkalanib pentacyclic triterpenoid tarkibi bir xil bo'lgan emas. Bu jigar kasalligi yordamchi va klinik davolash infektsiya uchun ishlatiladi. O'tkir sariq gepatit olganning aminotransferaz kamaytirish va yellowing.Oolic kislotasi swertia chinensis yoki fructus mevalaridan izolyatsiya pentacyclic triterpenoids gentianaceae zavodining ligustris ustida ochiq-oydin ta'sir bor. Oleanolic kislotasi keng 0,2% ~ 2% [1] umumiy mazmuni bilan, o'simliklarda topilgan. Calabash pastki mazmuni ~ 2% 1,5% edi, va fructus ligustris mevasidan tarkibi ~ 0,7% 0,6% bo'ldi. Oleanolic kislotasi oq ignasimon billur (o'rganish), hidsiz va ta'msiz bo'ladi. Kislotalar va bazlar uchun beqaror. ~ 310 308 nuqtasini eritish ℃, [alfa] 20 d + 73,3 ° (v = 0.15, xloroform, suvda erimaydigan metanol, eriydigan, o'rganish, etil, atseton va chloroform.Oleanolic kislotasi bo'lgan tabiiy triterpenoid, keng tarqatiladi efir Bu hokazo Phytolacca Americana (Amerika pokeweed), va Syzygium spp, sarimsoq, topish mumkin betulinic kislotasi bilan bog'liq oziq-ovqat va dorivor o'simliklar, ichida. Bu hepatoprotective, nisbatan zaharli bo'lmagan, va eksponatlar antitumor va viruslarga qarshi xususiyatlari.
Oleanolic kislotasi edi kuchli anti-OIV faoliyatini namoyish topilgan, tegishli aralashma betulinic kislotasi. birinchi tijorat kamolotga önleyicisi dori yaratish uchun ishlatilgan birinchi Rosa woodsii (barglari), Prosopis glandulosa (yaproqlar va shoxchalar), shu jumladan, bir necha o'simliklar, dan o'rganib va izolyatsiya qilingan, Phordendron juniperinum (butun o'simlik), Syzygium claviflorum (barglari), Hyptis capitata (butun o'simlik), va Ternstromia gymnanthera (antenna qismi). java olma, shu jumladan, boshqa Syzygium turlari (Syzygium samarangense) va olma ko'tarildi s uni o'z ichiga oladi.

Mahsulot nomi: Oleanolic kislota  98 %

Xususiyatlari: HPLC bilan 98%

Botanika Manba: Olea European Extract

Kimyoviy nomi: (3β) -3-Hydroxyolean-12-en-28-IKT kislotasi

CAS No: 508-02-1

Part Ishlatilgan: Leaf

Rangi: xarakterli hid va ta'mi bilan Oq kukun

GMO Status: GMO Free

Paket: 25kgs Gost So'nggi fıçılar ichida

Saqlash: salqin, quruq joyda ochilmagan holda saqlansin kuchli yorug'lik yuz saqlang

Raf umri: ishlab chiqarish boshlab 24 oy

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

Function:

1.Oleanolic kislotasi nisbatan-non zaharli, o'simta qarshi va hepatoprotective, shuningdek virusga qarshi xususiyatlarini namoyish etadi.
2.Oleanolic kislota kuchli anti-OIV faoliyatini namoyish qilish topildi.
3.Oleanolic kislotasi Oksidatif va elektrofil stress qarshi hujayralari yirik himoyachi hisoblanadi.
4.Oleanolic kislotasi virus gepatit, o'tkir sariq kasaliga oid gepatit va surunkali gepatit trating katta ta'sir ko'rsatadi.
Application:
oziq-ovqat sohasida 1. Amaliy, u balgamlanmasında kamaytirish choy xom ashyo sifatida mumkin bajaradi;
Farmatsevtika sohasida 2. Amaliy, u kam zaharli bilan yangi anti-saraton dori bo'ladi;
Kosmetik sohasida 3. Amaliy, qon aylanishini mustahkamlamoq va ichimliklar olib tashlash mumkin.