Oleanolic Acid Powder

Acid Oleanolic o se pentacyclic triterpenoids tolu faaesea mai laau Gentianaceae o Swertia mileensis le mutia atoa po o fua privet, ma se saoloto tino ma glycosides i le tele o laau. Acid Oleanolic ei ai le tele o ituaiga i le laau, ma o le aano averesi e 0.2% - 2%. Cucurbitaceae faamalieina maualuga e 1.5% ~ hunchback pito i lalo 2%, privet fua mataupu i totonu o 0,6% ~ 0,7% .Oleanolic acid o se ituaiga o lotoa pentacyclic triterpenoid faaesea mai le fua o le genus Asteraceae, Syzygium sylvestris, po Ligustrum lucidum. O se adjuvant faamaʻi ate ma clinically faaaoga mo siama togafitiga. Hepatitis jaundice matuitui ei ai aafiaga manino i faaitiitia aminotransferase alanine ma acid yellowing.Oolic o se pentacyclic triterpenoids faaesea mai le fua o swertia chinensis po fructus ligustris mai le laau gentianaceae. O loo maua lautele acid Oleanolic i le laau, ma se anotusi aoao o le 0.2% ~ 2% [1]. O le mataupu i totonu o pito i lalo o calabash sa 1.5% ~ 2%, ma o le aano o le fua o fructus ligustris sa 0,6% ~ 0,7%. Acid Oleanolic o tioata acicular sinasina (ethanol), odorless ma lē momose. Mautu e acids ma nofoaga autu. Teʻa tulaga o le 308 ~ 310 ℃, [Alefa] 20 d + 73.3 ° (c = 0,15, chloroform, insoluble i le vai, soluble i methanol, ethanol, Eteru ethyl, acetone ma chloroform.Oleanolic acid o se masani e tutupu triterpenoid, lautele tufatufaina i laau meaai ma faafomai, e faatatau i acid betulinic. e mafai ona maua i Americana Phytolacca (American pokeweed), ma Syzygium spp, kaliki, ma isi e matua lē oona, hepatoprotective, ma faaalia antitumor ma meatotino antiviral.
acid Oleanolic sa o loo maua e faaalia gaoioiga aneti-HIV malosi, o le fesootai lotoa acid betulinic sa faaaogaina e foafoa ai le fualaau faasaina inhibitor muamua maturation faapisinisi. na muamua suesue ma faaesea mai le tele o laau, e aofia ai Rosa woodsii (lau), Prosopis glandulosa (laulaau ma fasi laau), Phordendron juniperinum (laau atoa), Syzygium claviflorum (lau), Hyptis capitata (laau atoa), ma Ternstromia gymnanthera (vaega ea). ituaiga isi Syzygium aofia apu java (Syzygium samarangense) ma toetu apu s o loo i ai.

Oloa Igoa: Oleanolic oʻona  98 %

Specification: 98% le HPLC

Botanic Puna: Olea upu sii Europea

Vailaau Igoa: (3β) -3-Hydroxyolean-12-en-28-oic acid

CAS leai: 508-02-1

Vaega Faaaogaina: lau

Valivali: efuefu White ma le uiga manogi ma tofo

GMO Tulaga: Free GMO

Teuina: i 25kgs drums fibre

Teuina: Tausi pusa tatalaina i mālū, nofoaga matutu, Ia o ese mai le malamalama malosi

Fata Olaga: O le 24 masina mai le aso o le tuuina

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

galuega tauave:

Acid 1.Oleanolic loo matua lē oona, antitumor, ma hepatoprotective, faapea foi ma faaalia meatotino antiviral.
Na maua acid 2.Oleanolic e faaalia malosi gaoioiga aneti-HIV.
Acid 3.Oleanolic o se puipuiga tele o sela e faasaga i oxidative ma le popole electrophile.
Acid 4.Oleanolic ei ai aafiaga tele i trating siama hepatitis, hepatitis icteric matuitui ma hepatitis faaumiumi.
talosaga:
1. FAAAOGAINA i fanua meaai, e mafai ona galue e pei o mea e masani o le lauti e faaitiitia phlegm;
2. FAAAOGAINA i fanua vailaau, e avea o se fualaau fou aneti-kanesa ma maualalo oona;
3. FAAAOGAINA i fanua teuteu, e mafai ona faaolaolaina toto faasalalauina ma aveese meainu.