Oleanolic Acid Powder

Oleanolic acid taas oo ah saddex triterpenoids pentacyclic dhirta Gentianaceae of Swertia go'doonsan mileensis cawska ama privet ay midhaha oo dhammu, jidh xor ah oo glycosides in dhirta badan. Oleanolic acid uu leeyahay tiro balaadhan ee dhirta, iyo waxa ku jira celcelis ahaan waa 0.2% - 2%. Cucurbitaceae content sare waa 1.5% ~ hoose hunchback 2%, privet content midhaha of 0.6% ~ 0.7% .Oleanolic acid waa nooc ka mid ah xarunta triterpenoid pentacyclic Midhaha panulirus ku Asteraceae, Syzygium sylvestris, ama Ligustrum lucidum go'doonsan. Waa Curiyaha taageerada cudurka beerka iyo Caafimaad ahaan loo isticmaalo cudurka daweynta. Xiisad hepatitis joonis uu raad cad yaraynta alanine aminotransferase iyo yellowing.Oolic acid waa triterpenoids pentacyclic Midhaha chinensis swertia ama fructus go'doonsan ligustris ka warshad gentianaceae ah. Oleanolic acid waxaa si balaadhan looga helay dhirta, la content a guud ee 0.2% ~ 2% [1]. Content ee ugu hooseysa calabash ahaa 1.5% ~ 2%, iyo waxa ku jira oo miro ah ligustris fructus ahaa 0.6% ~ 0.7%. Oleanolic acid waa crystal cad acicular (ethanol), ur iyo Faylasha. Deganayn si acids iyo saldhigyadii. MILMA dhibic of 308 ~ 310 ℃, [Alfa] 20 d + 73.3 ° (c = 0.15, chloroform, beelaya biyo, L. ee methanol, ethanol, ethyl ether, acetone iyo chloroform.Oleanolic acid waa triterpenoid ah si dabiici ah ku dhaco, si weyn loo qaybiyey in dhirta cuntada iyo daawooyinka, la xiriira betulinic acid. Waxaa laga heli karaa Phytolacca americana (pokeweed American), iyo spp Syzygium, toon, iwm waa xad aan sun, hepatoprotective, iyo bandhigaa antitumor iyo guryaha fayruska.
Oleanolic acid ahaa helay in ay muujiyaan hawlaha la-dagaallanka HIV xoog, xarunta la xiriira ka betulinic acid waxaa loo isticmaalay si loo abuuro daroogada ugu horeeyay ee ganacsi inhibitor koriinkedu. Waa markii ugu horaysay la bartay iyo go'doonka ka ah dhirta dhawr, oo ay ku jiraan Rosa woodsii (caleemaha), Prosopis glandulosa (caleemaha iyo saqaf), Phordendron juniperinum (dhirta oo dhan), claviflorum Syzygium (caleemaha), capitata Hyptis (dhirta oo dhan), iyo gymnanthera Ternstromia (qayb ka mid anteeno). noocyada kale ee Syzygium oo ay ku jiraan tufaax Java (Syzygium samarangense) iyo kor u kacday tufaaxa s waxa ay ka kooban yihiin.

Product Name: Oleanolic Acid  98 %

Faahfaahinta: 98% by HPLC

Botanic Source: Warbixiinta Europea Olea

Name Chemical: (3β) -3-Hydroxyolean-12-en-28-OIC acid

CAS No: 508-02-1

Part Isticmaalay: Leaf

Color: budada White oo ur leh dabeecad iyo dhadhan

Status siibtey: siibtey Free

Xirxirida: in 25kgs fuusto fiber

Kaydinta: Weelka ku hay furin qabow meel, qallalan, ka iftiin xoog leh ku hayso iska

Shelf Life: 24 bilood laga bilaabo taariikhda of-soo-saarka

What is oleanolic acid?

Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid; it has benefits like antibacterial, anti-inflammatory, antitumor activities.

Where can you find oleanolic acid?

Oleanolic acid has used traditionally for the treatment of various diseases,you can find it in food and plants widely.

Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid too.

Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.

Hemsley Chinensis Cogn. Introduction

Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.

Familia: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Species: H. amabilis

The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.

Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate;  Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Medicinal Values:

Hemsleya chinensis Cogn. is mainly for detoxification, sterilization, anti-inflammatory, strengthening the stomach and relieving pain. Currently, there are extracts powder, or compound preparations such as capsules, tablets, gastrointestinal pills, etc., which are widely used in clinical practice.

Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.

Formulas containing Oleanolic acid in Food supplements

We found that the oleanolic acid used in health supplements mainly comes from three kinds of plant extracts: Loquat leaf extract, Hemsley Chinensis extract, and holy basil extract.

• Holy Basil powder (leaf) (0.4% Ursolic acid and Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (leaf) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid and Oleanolic acid, 1.5 mg)
• Loquat Extract (fruit) (providing Ursolic acid, Oleanolic Acid) (Standardized to Ursolic acid Per Serving 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have a similar chemical structure.

These triterpenoids compounds are known to exist in medicinal herbs and foods.

They have many common pharmacological properties: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, and antifertility activities.

OA and UA difference:

Biological Activities of Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

 – by Xin Wang, Hua Bai, etc. Researchers

OA exhibited an inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells.

OA induced apoptosis through the mitochondrial pathway, evidenced by inhibition of Akt/mammalian target of rapamycin pathway.

OA induced G2/M cell cycle arrest through p21-mediated down-regulation of cyclin B1/cdc2.

OA demonstrated significant antitumor activities in HCC in vivo and in vitro models. These data provide new insight into the mechanisms underlying the antitumor effect of OA.

In addition, research shows that OA and its derivative Oleanolic acid methyl ester also have effects on breast cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer cells…

2. Antimicrobial Activity

OA is expected to possess antimicrobial activity against a wide range of pathogens for it plays a vital role in defending against pathogens in plants.

OA showed moderate activity against Staphylococcus aureus and Bacillus Thuringiensis at 62.5 µg/mL and Escherichia coli, Salmonella Enterica, and Shigella dysenteriae at 31.2 µg/mL minimum inhibitory concentration (MIC).

3. Hepatoprotective Ability

One of the notable bioactivities of OA is the protection of the liver against toxicity and is currently being used as an over the hepatic counter drug in China.

In Wistar albino rats, OA from Flaveria Trinervia was used and had a significant protective effect on ethanol-induced liver toxicity by restoring the hepatotoxic serum marker enzyme levels. This study suggested the antioxidant ability of OA as another possible mechanism of its hepatoprotective ability.

Oleanolic Acid and its derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (sourced from olive), there are about 500 registered clinical trials, showed it had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis.

Most popular derivatives in clinical trials are bardoxolone methyl (CDDO-Me). CDDO-Me was evaluated in tumor biopsies, and it might be able to play a role in the treatment of chronic kidney disease, it is currently being assessed in effects on hypertension.

Chinese Pharmacopoeia Standard of Oleanolic Acid

Oleanolic acid recommend dosage

According to the Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose is 20~80mg per time,60~240mg per day.

Oleanolic acid side effects

Oleanolic acid used as an over the counter (OTC) hepatoprotective drug for decades in China.

If overdose or incorrect, a small number of patients have dry mouth, diarrhea, upper abdominal discomfort, and can disappear after symptomatic treatment.

Please consult your physician or pharmacist before using this product.

function:

1.Oleanolic acid waa non-sun, antitumor, iyo hepatoprotective, iyo sidoo kale soo bandhigista guryaha fayruska.
2.Oleanolic acid waxaa laga helay in ay muujiyaan hawlaha la-dagaallanka HIV xoog leh.
3.Oleanolic acid yahay gargaaraha weyn unugyada ka dhanka ah murqo iyo stress electrophile.
4.Oleanolic acid uu saameyn weyn ku trating hepatitis virus, hepatitis icteric ba'an iyo hepatitis chronic.
Codsiga:
1. Applied duurka cunto, ay u dhaqmo kartaan sida alaabta ceeriin ee shaaha si loo yareeyo xaakada,
2. Applied duurka dawooyinka, waxa uu noqonayaa mid daroogada anti-kansarka cusub sun hooseeyo;
3. Applied duurka isku qurxiyo, waxa ay hindisi karaa wareegga dhiigga iyo saaro sharaabka.