Pyrroloquinoline Quinone Disodium Salt (PQQ)

Lafiyar mu yana da tasiri da abubuwa da yawa.Masu siyayya ba za su iya danganta lafiyar fahimi nan da nan tare da jin daɗinsu gaba ɗaya ba, amma fahimi, na zahiri da ma lafiyar tunani suna da alaƙa sosai.Ana nuna wannan ta hanyar rashin abinci iri-iri na iya haifar da raguwar aikin fahimi (misali, B12 da magnesium).

Hakanan yana bayyana yayin da muke tsufa.Yayin da muka tsufa, ƙananan abubuwan gina jiki da jiki zai iya sha daga abinci, wanda zai iya haifar da rashi.Yana da sauƙi a watsar da mantuwa da rashin mayar da hankali a matsayin alamun tsufa, wanda suke, amma kuma alamun yanayin yanayin jikin mu ne sakamakon tsufa.Kari, ta hanyar samar da kasawa a cikin abubuwan gina jiki, na iya inganta aikin fahimi.Ga wasu takamaiman sinadarai masu alaƙa da lafiyar hankali.

Daya bisa uku na kwakwalwa ya ƙunshi polyunsaturated fatty acid (PUFA), lissafin kashi 15-30% na busassun nauyin kwakwalwa, tare da docosahexaenoic acid (DHA) wanda ya zama kusan kashi ɗaya bisa uku na wancan (1).

DHA shine omega-3 fatty acid wanda ke taka muhimmiyar rawa a cikin kwakwalwa, yana mai da hankali a cikin sassan kwakwalwar da ke buƙatar mafi girman aikin lantarki, ciki har da synaptosomes inda ƙarshen jijiyoyi ke haɗuwa da sadarwa tare da juna, mitochondria, wanda ke samar da makamashi don Kwayoyin jijiya, da kuma cerebral cortex, wanda shi ne murfin waje na kwakwalwa (2).An tabbatar da cewa DHA wani muhimmin sashi ne don haɓaka kwakwalwar jarirai da yara kuma yana da mahimmanci a duk tsawon rayuwa don kiyaye lafiyar fahimi.Muhimmancin DHA yayin da muke tsufa yana bayyana yayin kallon waɗanda ke fama da raguwar shekaru, kamar cutar Alzheimer (wani nau'i na lalata da ke haifar da ƙwaƙwalwar ci gaba, fahimi da raguwar ɗabi'a).

A cewar wani bita na Thomas et al., "A cikin marasa lafiya da aka gano tare da cutar Alzheimer, an gano ƙananan matakan DHA a cikin jini da kwakwalwa.Wannan ba wai kawai zai iya kasancewa saboda ƙarancin abinci na omega-3 fatty acids ba, amma kuma ana iya danganta shi da haɓakar iskar oxygen na PUFAs”(3).

A cikin marasa lafiya na Alzheimer, ana tsammanin raguwar fahimi ne ta hanyar furotin beta-amyloid, wanda ke da guba ga ƙwayoyin jijiya.Lokacin da matakan wannan furotin suka yi yawa, suna lalata manyan sassan ƙwayoyin kwakwalwa, suna barin amyloid plaques waɗanda ke da alaƙa da cutar (2).

Nazarin daban-daban sun nuna cewa DHA na iya samun tasirin neuroprotective ta hanyar rage yawan guba na beta-amyloid kuma ta hanyar samar da sakamako mai hana kumburi wanda zai iya rage amyloid plaque wanda ya haifar da danniya na oxidative da rage matakan furotin oxidized da 57% (2).Yayin da rashi DHA a cikin masu fama da cutar Alzheimer na iya samun wasu abubuwan da za a iya amfani da su ga yadda kari zai amfane su, ya kamata a lura cewa kari ba zai iya warkar da wannan ko wata cuta ba da kuma nazarin da ke magance wannan batu ya sami sakamako mai gauraya.

Ƙarin ba magani ba ne, kuma gaskiyar ita ce masu cutar Alzheimer da suka tsufa za su amfana da mafi ƙarancin daga DHA ko wasu abubuwan gina jiki don tallafin fahimi saboda lokacin da aka gano su, an riga an yi lahani ga kwakwalwa.

Duk da haka, wasu masu bincike suna binciken ko karin DHA na iya rage ci gaban fahimi.Ita Shafat Ph.D., babban masanin kimiyya don sashin abinci mai gina jiki a Enzymotec, Ltd., tare da ofishin Amurka a Morristown, NJ, ya buga wani binciken da Yourko-Mauro et al.wanda ya samo, "Ƙarin 900 MG / rana DHA don makonni 24, zuwa batutuwa masu shekaru> 55 tare da raguwar fahimta mai tsaka-tsaki, inganta ƙwaƙwalwar ajiya da ƙwarewar ilmantarwa" (4).

Yayin da wasu masu amfani ba za su yi tunani game da lafiyar hankali ba har sai matsaloli sun taso, yana da mahimmanci ga masu sayarwa su tunatar da su muhimmancin DHA ga kwakwalwa a duk rayuwarsu.A zahiri, DHA na iya tallafawa lafiyar fahimi na matasa waɗanda ke da lafiya kuma ba su da ƙarancin ƙarancin abinci.Wani gwajin da bazuwar bazuwar kwanan nan ta Stonehouse et al., Nazarin 176 lafiya manya masu shekaru 18 zuwa 45, sun gano, “Kariyar DHA ta inganta ingantaccen lokacin ƙwaƙwalwar episodic, yayin da daidaiton ƙwaƙwalwar episodic ya inganta a cikin mata, da lokacin amsawa. An inganta ƙwaƙwalwar ajiyar aiki a cikin maza" (5).Wannan haɓakawa a ɗan ƙaramin shekaru na iya fassarawa zuwa jiki da hankali da aka shirya don ƙalubalen tsufa.

Alpha-linolenic acid (ALA) shine omega-3, yawanci ana samo shi daga tsire-tsire kamar chia da flaxseed a matsayin madadin mai na ruwa.ALA mafari ne zuwa DHA, amma jujjuya matakai da yawa daga ALA zuwa DHA ba shi da inganci a cikin mutane da yawa, don haka yana sa DHA na abinci mai mahimmanci don tallafin fahimi.ALA, duk da haka, tana da wasu muhimman ayyuka a nata dama.Herb Joiner-Bey, mai ba da shawara kan kimiyyar likitanci na Barlean, Ferndale, WA, ya ce ALA kuma, “waɗanda ƙwayoyin kwakwalwa ke amfani da su don yin hormones na gida, gami da 'neuroprotectins,' masu mahimmanci ga aikin kwakwalwa."Ya ce ana kuma gano cewa neuroprotectins ba su da yawa a cikin masu cutar Alzheimer kuma a cikin gwaje-gwajen dakin gwaje-gwaje, ALA an dauke su da mahimmanci ga ci gaban kwakwalwa.

Abubuwan da za a yi la'akari da su lokacin shan abubuwan da ake amfani da su na DHA sune sashi ne da kuma bioavailability.Mutane da yawa ba sa samun isasshen DHA a cikin abincin su kuma za su amfana da ɗaukar ma'auni mai mahimmanci ko mafi girma.An kawo mahimmancin sashi kwanan nan a cikin binciken shekaru biyar na Chew et al.wanda bai sami babban bambanci ba a cikin aikin fahimi a lokacin ƙarin omega-3 a cikin batutuwan tsofaffi (ma'anar shekaru: 72) tare da lalata macular degeneration na shekaru.Yawancin masana abinci mai gina jiki sun kasance masu shakka game da ƙirar binciken.Misali, Jay Levy, darektan tallace-tallace na Wakunaga na Amurka Co., Ltd., Ofishin Jakadancin Viejo, CA, ya ce, “Bayanan DHA ya kasance 350 MG kawai yayin da binciken meta-binciken kwanan nan ya gano cewa ana buƙatar alluran DHA na yau da kullun sama da 580 MG. bayar da fa'idodin aikin fahimi" (6).

Douglas Bibus, Ph.D., memba na kwamitin ba da shawara na kimiyya na Coromega, Vista, CA, ya buga labarin da Ƙungiyar Duniya ta EPA da DHA Omega-3s (GOED) ta yi mai suna "Omega-3s da Cognition: Dosage Matters."Kungiyar ta gano, bayan "nazarin binciken 20 na tushen fahimi da aka gudanar a cikin shekaru 10 da suka gabata, kawai binciken da ke ba da 700 MG na DHA ko fiye a kowace rana ya ba da sakamako mai kyau" (7).

Wasu nau'ikan isarwa na iya sa mai na ruwa ya zama abin sha.Misali, Andrew Aussie, mataimakin shugaban zartarwa kuma babban jami’in gudanarwa a Coromega, ya ce kamfaninsa ya ƙware a cikin, “emulsified omega-3 supplements that offers 300% better absorption.”Bisa ga binciken da Raatz et al.cewa Aussie ya ambata, emulsification na lipid a cikin ciki shine muhimmin mataki a cikin narkewar mai "ta hanyar samar da haɗin gwiwar ruwa mai mahimmanci don hulɗar tsakanin lipases mai narkewa da ruwa mai narkewa" (8).Don haka, ta hanyar kwaikwayi man kifi, ana ƙetare wannan tsari, yana haɓaka ƙarfinsa (8).

Wani abu da ke shafar bioavailability shine nau'in kwayoyin omega-3.Chris Oswald, DC, CNS, memba na kwamitin shawarwari a Nordic Naturals, Watsonville, CA, ya yi imanin cewa nau'in triglyceride na omega-3s ya fi tasiri wajen haɓaka matakan jini fiye da nau'in roba.Idan aka kwatanta da kwayoyin ethyl ester na roba, nau'in triglyceride na halitta yana da ƙarancin juriya ga narkewar enzymatic, yana mai da shi har zuwa 300% ƙarin sha (2).Saboda tsarin kwayoyin halittarsa ​​na fatty acid guda uku da ke makale da kashin bayan glycerol, lokacin da aka narkar da mai kifi, abin da ke cikinsa yana juyewa zuwa fatty acid guda daya.Bayan an shafe su ta cikin sel na epithelial, an sake komawa cikin triglycerides.Wannan yana yiwuwa ta hanyar kashin baya na glycerol, wanda ethyl ester ba zai samu (2).

Wasu kamfanoni sun yi imanin phospholipid-daure omega-3s zai inganta sha.Cheryl Meyers, shugaban ilimi da harkokin kimiyya a EuroPharma, Inc., Greenbay, WI, ya ce wannan tsarin "ba wai kawai yana aiki ne a matsayin hanyar sufuri na omega-3s ba, har ma yana ba da goyon baya ga kwakwalwa da kansu."Myers ta bayyana ƙarin kari guda ɗaya daga kamfaninta wanda ke ba da omega-3 mai ɗaure phospholipid wanda aka samo daga kawunan salmon (Vectomega).Har ila yau, ƙarin ya ƙunshi peptides waɗanda ta yi imanin "na iya kare magudanar jini a cikin kwakwalwa ta hanyar yaƙar lalacewar oxidative."

Don dalilai makamantan haka, wasu kamfanoni suna zaɓar su ƙirƙira tare da mai krill, wani tushen tushen omega-3s na phospholipid wanda ke ba da ingantaccen bioavailability saboda ƙarancin ruwa.Lena Burri, darektan rubuce-rubucen kimiyya a Aker Biomarine Antarctic AS, Oslo, Norway, yana ba da ƙarin bayani game da dalilin da yasa wannan nau'in DHA yake da mahimmanci: ɗayan “DHA transporter (Mfsd2a, babban mai gudanarwa babban yanki na dangi wanda ya ƙunshi 2a)… yana karɓar DHA kawai idan yana daure zuwa phospholipids - don zama daidai ga lysoPC" (9).

Ɗaya daga cikin bazuwar, makafi biyu, nazarin kwatankwacin rukuni-rukuni ya auna tasirin man krill, man sardine (nau'in triglyceride) da placebo akan ƙwaƙwalwar aiki da ayyukan lissafi a cikin 45 mazan maza masu shekaru daga 61-72 na makonni 12.Ta hanyar aunawa canje-canje na ƙididdigar oxyhemoglobin yayin ayyuka, sakamakon ya nuna babban canje-canje a cikin maida hankali a cikin wani tashar tashoshi bayan makonni 12 fiye da placebo, yana ba da shawarar cewa dogon lokaci kari na duka krill da sardine man "yana inganta aikin ƙwaƙwalwar ajiya ta hanyar kunna dorsolateral prefrontal cortex a cikin tsofaffi. mutane, don haka yana hana lalacewa cikin ayyukan fahimi”(10).

Duk da haka, game da ayyukan ƙididdiga, man krill "ya nuna canje-canje mafi girma a cikin adadin oxyhemoglobin a cikin gefen hagu na gaba," idan aka kwatanta da placebo da sardine man fetur, wanda bai nuna wani tasiri na kunnawa ba yayin ayyukan lissafin (10).

Banda taimakawa wajen sha na omega-3s, phospholipids suna taka muhimmiyar rawa a lafiyar hankali a cikin haƙƙinsu.A cewar Burri, phospholipids sun kasance kusan kashi 60% na kwakwalwa ta nauyi, musamman wadatar dendrites da synapses.Baya ga wannan, ta ce a cikin vitro, haɓakar jijiyoyi yana haifar da ƙarin buƙatun phospholipids da haɓakar jijiyoyi suna ƙarfafa haɓakar phospholipid.Ƙarfafawa tare da phospholipids ana amfani da shi sosai kuma yana da tasiri wajen taimakawa aikin fahimi saboda tsarin su yayi kama da waɗanda ke cikin membranes na jijiya.

phospholipids guda biyu na kowa sune phosphatidylserine (PS) da phosphatidylcholine (PC).Shafat ya ce PS yana da ƙwararrun da'awar kiwon lafiya da Hukumar Abinci da Magunguna ta Amurka (FDA) ta amince.Da'awar sun haɗa da: "Yin amfani da PS na iya rage haɗarin lalata a cikin tsofaffi," "Yin amfani da PS na iya rage haɗarin rashin aiki na rashin fahimta a cikin tsofaffi," kuma ya cancanta tare da, "Mai iyakancewa da bincike na farko na kimiyya ya nuna cewa PS na iya rage haɗari. na lalata / rage haɗarin rashin aiki na fahimi a cikin tsofaffi.FDA ta kammala cewa akwai 'yan kaɗan shaidar kimiyya da ke tallafawa wannan da'awar. "

Shafat ya bayyana cewa a kan kansa, PS "yana da tasiri a cikin kashi na 100 MG / rana," ƙananan adadin fiye da wasu kayan aikin tallafi na fahimi.

Dangane da aikinsa, Chase Hagerman, darektan alama a ChemiNutra, White Bear Lake, MN, ya ce PS "yana taimakawa sunadaran da ke sarrafa ayyukan membrane da ke cikin watsa sakonnin kwayoyin halitta daga tantanin halitta zuwa tantanin halitta, yana taimakawa masu gina jiki su shiga cikin sel, kuma suna taimakawa. Abubuwan sharar da ke da alaƙa da damuwa don fita daga tantanin halitta.

PC, a gefe guda, irin wannan da aka samo daga alpha-glyceryl phosphoryl choline (A-GPC), Hagerman ya ce, "yana ƙaura zuwa ƙarshen jijiya na synaptic da aka samu a cikin dukan tsarin kulawa na tsakiya, kuma hakan yana ƙara haɓakawa da saki. acetylcholine (AC)," wanda shine muhimmin neurotransmitter "wanda yake yanzu a cikin kwakwalwa da nama na tsoka," yana taka muhimmiyar rawa a "mahimmanci kowane aikin fahimi yayin da yake cikin tsoka yana da hannu sosai a cikin ƙwayar tsoka."

Abubuwa iri-iri suna aiki har zuwa wannan.Dallas Clouatre, Ph.D., R & D mai ba da shawara a Jarrow Formulas, Inc., Los Angeles, CA, ya bayyana su a matsayin "dangi na musamman na musamman," wanda ya hada da uridine, choline, CDP-choline (Citocoline) da PC kamar yadda wani sashe na sake zagayowar kwakwalwa wani lokaci ana kiransa da zagayowar Kennedy.Duk waɗannan abubuwa suna taka rawa wajen ƙirƙirar PC a cikin kwakwalwa kuma ta haka suna haɗa AC.

Samar da AC wani abu ne da ke raguwa yayin da muke tsufa.Koyaya, gabaɗaya, saboda ƙananan ƙwayoyin cuta ba za su iya samar da nasu choline ba kuma dole ne su karɓi shi daga jini, ƙarancin abinci na choline yana haifar da ƙarancin wadatar AC (2).Rashin samun choline yana taka rawa wajen haɓaka cututtuka kamar Alzheimer's da raguwar fahimi masu alaƙa da shekaru.Ayyukan mai bincike Richard Wurtman, MD, daga Cibiyar Fasaha ta Massachusetts ya ba da shawarar cewa saboda rashin isasshen choline, kwakwalwa na iya iya cinye PC daga membrane na jijiyar jiki don yin AC (2).

Neil E. Levin, CCN, DANLA, manajan ilimin abinci mai gina jiki a NOW Foods, Bloomingdale, IL ya bayyana wani tsari "wanda ke goyan bayan faɗakarwar tunani da ilmantarwa ta hanyar inganta samar da AC mai kyau da aiki," ta hanyar hada A-GPC, "nau'in nau'in choline na bioavailable. " tare da Huperzine A don kula da matakan AC (RememBRAIN daga Abincin Yanzu).Huperzine A yana kula da AC ta hanyar aiki azaman mai hanawa na acetylcholinesterase, wanda shine enzyme wanda ke haifar da rushewar AC (11).

A cewar Levy, citicoline yana daya daga cikin sabbin sinadarai don tallafawa cognition, wanda ke niyya ga lobe na gaba, wanda shine yankin da ke da alhakin warware matsalolin, hankali da kuma maida hankali.Ya ce kari tare da citicoline a cikin tsofaffi ya nuna don "inganta ƙwaƙwalwar magana, aikin ƙwaƙwalwar ajiya da fahimta, tazarar hankali, kwararar jini zuwa kwakwalwa da ayyukan bioelectrical."Ya ambaci yawancin binciken da ya nuna sakamako mai kyau, ciki har da makafi biyu, bazuwar, gwajin gwaji na marasa lafiya na 30 na Alzheimer wanda ya nuna ingantaccen aikin fahimi idan aka kwatanta da placebo bayan shan citicoline yau da kullum, musamman ma a cikin wadanda ke da ƙananan ƙwayar cuta (12).

Elyse Lovett, manajan tallace-tallace a Kyowa USA, Inc., New York, NY, ta ce kamfaninta yana da "nau'in citicoline kawai da aka yi nazari a cikin manya da matasa masu lafiya," kuma shine "kawai nau'in citicoline tare da GRAS [gaba ɗaya. an gane shi azaman mai lafiya] matsayi a cikin Amurka" (Cognizin).

Wani ƙarin abin da ke da alaƙa, a cewar Dan Lifton, shugaban Maypro's Proprietary Branded Ingredients Group, Purchase, NY, shine INM-176 wanda aka samo daga tushen Angelica gigas Nakai, wanda kuma aka nuna don tallafawa lafiyar fahimi ta hanyar haɓaka matakan kwakwalwa na AC.

Karancin bitamin sau da yawa suna gabatar da kansu ta hanyar raguwar aikin fahimi.Rashi na bitamin B12, alal misali, na iya haɗawa da alamomi kamar ruɗewa, asarar ƙwaƙwalwar ajiya, sauye-sauyen mutumtaka, damuwa, damuwa da sauran halaye masu kama da lalata.Ba wai kawai ba, amma 15% na tsofaffi kuma kusan 40% na mutanen da ke da alamun bayyanar cututtuka fiye da shekaru 60 suna da ƙananan matakan B12 ko iyaka (13).

A cewar Mohajeri et al., B12 yana taka muhimmiyar rawa wajen canza homocysteine ​​​​(Hcy) zuwa amino acid methionine, amma sauran bitamin B folate (B9) da B6 sune mahimmancin haɗin gwiwa don haɓakawa ya faru, ba tare da haka ba, Hcy yana tarawa.Hcy shine amino acid da aka samar a cikin jiki daga methionine na abinci kuma yana da mahimmanci ga aikin salula na yau da kullum, amma yawan adadinsa yana lalata aikin da aka ce (14)."An nuna matakan jini mai girma na homocysteine ​​​​ya daidaita ƙwaƙwalwar ajiya da kuma wasu nau'o'in aikin tunani," in ji Michael Mooney, darektan kimiyya da ilimi a SuperNutrition, Oakland, CA.

Mohajeri et al.yana ƙarfafa wannan bayanin: “An danganta tsananin rashin fahimi tare da ƙara yawan adadin Hcy na plasma.Bugu da ƙari, an ba da rahoton haɗarin cutar Alzheimer mai girma yayin da matakan folate da B12 suka yi ƙasa” (15).

Niacin wani bitamin B ne wanda ke tallafawa aikin ƙwaƙwalwa da fahimi.A cewar Mooney, niacin, mafi yawan nau'in bitamin B3, sau da yawa likitoci sun ba da izini a 1,000 MG ko fiye a kowace rana don tallafawa matakan cholesterol na al'ada, amma binciken da aka sarrafa na placebo ya gano cewa kashi 425 na abinci mai gina jiki a kowace rana yana inganta ƙwaƙwalwar ajiya. gwada maki da kusan kashi 40 cikin 100 tare da inganta rijistar azanci da yawa da kusan kashi 40%.A mafi girma ƙarfi, niacin kuma ana nuna shi don inganta kwararar jini na cerebral, "wanda ke ƙara yawan zagayawa na abubuwan gina jiki da oxygen a cikin kwakwalwa," in ji (16).

Baya ga niacin, Mooney ya bayyana niacinamide, wanda shine wani nau'i na bitamin B3.A 3,000 MG / rana, UC Irvine yana nazarin niacinamide a matsayin yiwuwar maganin cutar Alzheimer da asarar ƙwaƙwalwar ajiya da ke hade da shi bayan sakamako mai kyau a cikin binciken linzamin kwamfuta.Dukansu nau'ikan, in ji shi, suna canzawa a cikin jiki zuwa NAD +, kwayar halittar da aka nuna don juyar da tsufa a cikin mitochondria, mai mahimmancin mai samar da makamashi ta salula."Wannan yana iya zama muhimmiyar gudummawa ga haɓaka ƙwaƙwalwar ajiyar bitamin B3 da sauran tasirin rigakafin tsufa," in ji shi.

Wani ƙarin don ba da shawarar abokan ciniki shine PQQ.Clouatre ya ce wasu suna ganin shi ne kawai sabon bitamin da aka gano a cikin shekaru da dama da suka gabata, wanda ke nuna sakamako mai kyau a wuraren da suka shafi neuroprotection."PQQ yana hana yawan tsararru masu yawa na masu tsattsauran ra'ayi, ciki har da mummunar cutarwa ta peroxynitrite," in ji shi, kuma a cikin PQQ ya nuna sakamako mai kyau a cikin ilmantarwa da ƙwaƙwalwar ajiya a cikin nazarin dabba da ɗan adam.Ɗaya daga cikin gwaji na asibiti ya gano cewa haɗin 20 MG na PQQ da CoQ10 sun ba da fa'idodi masu yawa a cikin batutuwan ɗan adam a cikin ƙwaƙwalwar ajiya, hankali da fahimta (17).

Lifton ya ce kamar niacin, PQQ da CoQ10 suna tallafawa aikin mitochondrial.Ya ce CoQ10 yana yin haka ta hanyar kare "mitochondria musamman daga lalacewa saboda ci gaba da cin zarafi na 'yanci," da kuma haɓaka "samar da makamashin salula, wanda zai iya haifar da ƙarin makamashi don samun hanyoyin fahimtar juna."Wannan yana da mahimmanci saboda "sabon bincike mai ban sha'awa ya nuna cewa ɗaya daga cikin manyan abubuwan da ke haifar da ƙananan ƙwaƙwalwar ajiya da ke da alaƙa da tsufa shine lalacewa ga mitochondria," in ji Lifton.

Magnesium wani muhimmin ma'adinai ne don kiyaye kyakkyawan aiki na fahimi, ko don wannan al'amari, aikin jiki gaba ɗaya.A cewar Carolyn Dean, MD, ND, memba na kwamitin ba da shawara na likita na Ƙungiyar Magnesium Gina Jiki, "Magnesium kadai ana buƙatar a cikin 700-800 tsarin enzyme daban-daban" da kuma "ATP (adenosine triphosphate) samarwa a cikin sake zagayowar Krebs ya dogara da magnesium na shida. daga cikin matakansa takwas.”

A bangaren fahimi, Dean ya ce magnesium yana toshe kumburin neuro-kumburi da ke haifarwa ta hanyar adibas na alli da sauran karafa masu nauyi a cikin sel kwakwalwa da kuma kiyaye tashoshi na ion da kuma toshe karafa masu nauyi shiga.Ta bayyana cewa lokacin da magnesium ya ragu, calcium yana shiga kuma yana haifar da mutuwar kwayoyin halitta.Levin ya kara da cewa, "Bincike na baya-bayan nan ya nuna cewa yana da matukar mahimmanci ga lafiyar kwakwalwa ta al'ada da aikin fahimi na yau da kullun ta hanyar kiyaye yawa da kwanciyar hankali na synapses na neuronal."

A cikin littafinta mai suna The Magnesium Miracle, Dean ta bayyana cewa rashi a cikin magnesium kadai na iya haifar da alamun cutar hauka.Wannan gaskiya ne musamman yayin da muka tsufa, tun da ikon jiki na shan magnesium daga abincinmu yana raguwa kuma magunguna na iya hana su ta hanyar tsofaffi (18).Don haka, matakan magnesium a cikin jini na iya raguwa saboda jiki ba shi da ikon ɗaukar ma'adinai, rashin abinci mara kyau da magunguna, haifar da wuce haddi na calcium da glutamate (musamman idan cin abinci mai yawa a cikin MSG), dukansu suna da rawar da zasu taka. a cikin nakasasshen jijiyoyi na yau da kullum da kuma ci gaba da ciwon hauka (19).

Duk da yake abubuwan gina jiki suna da mahimmanci don kiyaye aikin fahimi lafiya, kayan taimako na ganye kuma na iya ba da ƙarin tallafi ta hanyoyi daban-daban.Za a iya haifar da raguwar fahimi da ke da alaƙa da shekaru ta hanyoyi daban-daban, tare da rage kwararar jini na cerebral yana ɗaya daga cikin hanyoyin da suka bambanta.Ganye da yawa suna aiki don fuskantar wannan lamarin.Ya kamata a lura cewa ganyen da ke inganta yanayin jini na iya zama haɗari ga abokan cinikin da suka riga sun sha maganin rage jini kamar warfarin.

Babban aikin Gingko biloba shine haɓaka kwararar jini a cikin kwakwalwa, wanda ke taka rawa sosai wajen haɓakar cutar hauka ko farkon cutar Alzheimer ko cerebrovascular.An kuma ce don mayar da aikin mitochondrial maras kyau don inganta samar da makamashi na neuronal, ƙara yawan ƙwayar choline a cikin hippocampus, hana tarawa da guba na furotin b-amyloid kuma yana da tasirin antioxidant (20, 21).

Levy ya ambaci wani binciken matukin jirgi na mako hudu a cikin Neuroradiology cewa "ya bayyana karuwa zuwa kashi hudu zuwa bakwai a cikin jini na kwakwalwa a matsakaicin kashi na 120 MG kowace rana" na gingko (22).Wani bazuwar bazuwar, mai sarrafa wuribo, binciken makafi biyu wanda ke tantance inganci da amincin gingko biloba akan marasa lafiya da raunin fahimi da alamun cututtukan neuropsychiatric (NPS) ta Gavrilova et al., Ya gano cewa “a yayin aikin 24-mako na jiyya, ingantawa a cikin NPS da iyawar fahimta sun kasance masu mahimmanci kuma akai-akai mafi mahimmanci a cikin marasa lafiya da ke shan 240 MG kowace rana na G. biloba cire EGb 761 fiye da marasa lafiya da ke shan placebo"(23).

Ana gwada ingancin gingko biloba akan wasu yanayi kamar rashin kulawa da hankali (ADHD) a cikin yara.Ɗayan iyaka amma bincike mai ban sha'awa ta Sandersleben et al.ya bayar da rahoton cewa, bayan da aka karawa da gingko, “an sami ci gaba mai ma’ana ga iyaye game da kima da kula da ‘ya’yansu...haɓaka hankali, rashin sha’awa, da jimillar tsananin alamun sun ragu sosai,” kuma, “muhimmin ci gaba game da Halayen Prosocial” (24) .Saboda iyakokin binciken, kamar rashin samun iko ko mafi girma samfurin, ba za a iya zana ƙwaƙƙwaran ƙarshe akan ingancinsa ba, amma da fatan zai ƙarfafa ƙarin cikakkun bayanai na bazuwar, gwaji na sarrafawa.

Wani ganyen da ke aiki makamancin haka shine Bacopa monniera wanda, a cewar Levy, wani binciken dabba na baya-bayan nan a cikin Binciken Phytotherapy ya nuna “karu 25% na yawan jini zuwa kwakwalwa a tsakanin dabbobin da ke shan 60 MG na bacopa monniera kowace rana idan aka kwatanta da babu karuwa a cikin wadanda aka ba da donedpezil. (25).

An kuma ce yana da kaddarorin antioxidant.A cewar Shaheen Majeed, darektan tallace-tallace na Sabinsa Corp., East Windsor, NJ, bacopa "yana hana lipid peroxidation kuma ta haka yana hana lalacewa ga cortical neurons."Lipid peroxidation yana faruwa a lokacin damuwa na oxidative da ke hade da rashi DHA, wanda kuma, alama ce ta Alzheimer's.

Mary Rove, ND, mai koyar da aikin likita a Gaia Herb, Brevard, NC, ta kuma ambaci ƙara kayan aikin su na Gingko tare da ganye irin su ruhun nana da Rosemary.A cewarta, ruhun nana yana tallafawa faɗakarwa kuma "bincike ya inganta akan rosmaranic acid, wani yanki mai aiki tare da kaddarorin antioxidant."Ta kara da cewa, "akwai bayanai na zamani da yawa da za su rike wannan karamar taken 'rosemary don tunawa'."

Huperzine A, wanda aka ambata a baya don aikinsa a matsayin mai hana acetylcholinesterase, an samo shi daga ganyen Huperzia serrata na kasar Sin.Ƙarfinsa na hana rushewar acetylcholine yayi kama da na magungunan FDA da aka amince da su don magance alamun cutar Alzheimer ciki har da donepezil, galantamine da rivastigmine, wadanda ke hana cholinesterase (11).

Meta-bincike wanda Yang et al.Ya ƙarasa, "Huperzine A yana da alama yana da wasu fa'idodi masu fa'ida akan haɓaka aikin fahimi, ayyukan rayuwar yau da kullun da kima na asibiti na duniya a cikin mahalarta masu cutar Alzheimer."Sun yi gargadin, duk da haka, cewa ya kamata a fassara binciken da hankali saboda rashin kyawun tsarin gwajin da aka haɗa, kuma sun yi kira da a ƙara tsauraran gwaji (11).

Antioxidants.Yawancin abubuwan da aka tattauna suna da ƙarfin maganin antioxidant, wanda ke taimaka musu su yi tasiri a kan raunin fahimi, wanda matsalolin oxidative sukan ba da gudummawa.A cewar Meyers, "A kusan dukkanin cututtuka a cikin kwakwalwa, kumburi yana da mahimmanci - yana canza yanayin yadda kwayoyin halitta suke hulɗa da juna."Shi ya sa aka samu karuwar shahara da bincike kan curcumin, wanda wani sinadari ne da aka samu daga turmeric, wanda aka nuna yana rage kumburi da illar da ake samu a cikin kwakwalwa da kuma tallafawa yadda ya kamata a harba neurons, in ji Meyers.

A cikin yanayin yanayi kamar Alzheimer's, curcumin na iya samun yuwuwar rushe ginin beta-amyloid.Ɗaya daga cikin binciken da Zhang et al., wanda ya gwada curcumin akan al'adun cell da linzamin kwamfuta na farko na cortical neurons, ya gano cewa ganyen yana rage matakan beta-amyloid ta hanyar rage girma na amyloid-beta precursor protein (APP).Ya rage girman APP ta hanyar haɓaka kwanciyar hankali na APP wanda bai balaga ba tare da rage kwanciyar hankali na balagagge APP (26).

Ana buƙatar ƙarin bincike don cikakken fahimtar nau'in tasirin curcumin zai iya haifar da fahimi da kuma yadda zai iya inganta rashin fahimta.A halin yanzu, McCusker Alzheimer's Research Foundation yana tallafawa binciken da ake gudanarwa a Jami'ar Edith Cowan da ke Perth, Ostiraliya, don gwada ingancin curcumin a kan marasa lafiya da ƙarancin fahimi.Binciken na watanni 12 zai tantance ko ganyen zai kiyaye aikin fahintar marasa lafiya.

Wani antioxidant mai ƙarfi wanda ke tallafawa aikin fahimi shine Pycnogenol (wanda aka rarraba ta Horphag Research).Bayan kasancewarsa mai girma da ƙarfi akan lalacewar iskar oxygen, ganyen, wanda aka samo daga bawon pine pine na Faransa, an kuma nuna yana inganta yanayin jini, gami da microcirculation a cikin kwakwalwa tare da haɓaka samar da nitric oxide, wanda ke aiki azaman neurotransmitter. , mai yiwuwa yana ba da gudummawa ga ƙwaƙwalwar ajiya da ƙwarewar ilmantarwa (25).A cikin nazarin mako takwas guda ɗaya, masu bincike sun ba wa ɗalibai 53 masu shekaru daga 18 zuwa 27 Pycnogenol kuma sun kimanta aikin su akan gwaje-gwaje na ainihi.Sakamakon ya nuna cewa ƙungiyar gwaji ta kasa gwaje-gwaje kaɗan fiye da sarrafawa (bakwai vs tara) kuma sun yi 7.6% fiye da sarrafawa (27).WF

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An buga a cikin Mujallar WholeFoods Janairu 2016

Mujallar WholeFoods ita ce tushen ku ta tsayawa ɗaya don labaran kiwon lafiya da abinci mai gina jiki na yanzu, gami da salon rayuwa marasa alkama da ƙarin labarai na abinci.

Manufar labarin lafiyarmu da abinci mai gina jiki shine sanar da dillalan samfuran halitta da masu siyarwa game da sabon samfurin halitta da ƙarin labarai na abinci, ta yadda za su iya amfani da sabbin damammaki da haɓaka kasuwancinsu.Mujallarmu tana ba da mahimman bayanai game da sabbin nau'ikan samfuran masana'antu da masu tasowa, da kimiyyar abubuwan da ke tattare da abubuwan abinci masu mahimmanci.