Thanzi lathu limakhudzidwa ndi zinthu zambiri.Ogula sangaphatikizepo nthawi yomweyo thanzi lachidziwitso ndi thanzi lawo lonse, koma chidziwitso, thanzi komanso malingaliro amalumikizana kwambiri.Izi zikuwonetsedwa m'njira yomwe kuperewera kwa zakudya m'thupi kungayambitse kuchepa kwa chidziwitso (mwachitsanzo, B12 ndi magnesium).
Zimaonekeranso tikamakalamba.Tikamakula, m’pamenenso thupi limatha kuyamwa zakudya zopatsa thanzi m’zakudya, zomwe zingabweretse kupereŵera.N'zosavuta kunyalanyaza kuiwala ndi kusowa chidwi monga zizindikiro za msinkhu, zomwe ziri, koma zimakhalanso chizindikiro cha chikhalidwe chonse cha matupi athu chifukwa cha ukalamba.Kuphatikizikako, popanga zoperewera muzakudya, kungathenso kupititsa patsogolo chidziwitso.Nazi zina mwazakudya zapadera zomwe zimakhudzana ndi thanzi lachidziwitso.
Gawo limodzi mwa magawo atatu a ubongo limapangidwa ndi ma polyunsaturated fatty acids (PUFA), omwe amawerengera 15-30% ya kulemera kouma kwa ubongo, ndi docosahexaenoic acid (DHA) yomwe imapanga gawo limodzi mwa magawo atatu a (1).
DHA ndi omega-3 fatty acid yomwe imagwira ntchito yofunika kwambiri muubongo, imayang'ana mbali zina zaubongo zomwe zimafunikira mphamvu yayikulu kwambiri yamagetsi, kuphatikiza ma synaptosomes pomwe malekezero a minyewa amakumana ndikulumikizana wina ndi mnzake, mitochondria, yomwe imatulutsa mphamvu yamagetsi. ma cell a mitsempha, ndi cerebral cortex, yomwe ndi gawo lakunja la ubongo (2).Ndizodziwika bwino kuti DHA ndi gawo lofunikira pakukula kwa ubongo wa makanda ndi mwana ndipo ndikofunikira pamoyo wonse kuti akhalebe ndi thanzi labwino lachidziwitso.Kufunika kwa DHA tikamakalamba kumawonekera poyang'ana omwe akukhudzidwa ndi kuchepa kwa zaka, monga matenda a Alzheimer's (mtundu wa dementia womwe umayambitsa kukumbukira pang'onopang'ono, kuzindikira ndi kuchepa kwa khalidwe).
Malinga ndi ndemanga ya Thomas et al., "Odwala omwe adapezeka ndi matenda a Alzheimer's, milingo yotsika kwambiri ya DHA idapezeka mu plasma yamagazi ndi ubongo.Izi sizingakhale chifukwa cha kuchepa kwa zakudya za omega-3 fatty acids, komanso zikhoza kukhala chifukwa cha kuchuluka kwa okosijeni kwa PUFAs "(3).
Odwala a Alzheimer's, kuchepa kwachidziwitso kumaganiziridwa kuti kumayambitsidwa ndi mapuloteni a beta-amyloid, omwe ndi oopsa ku maselo amitsempha.Mapuloteniwa akachuluka, amawononga ma cell akuluakulu a muubongo, ndikusiya ma amyloid plaques omwe amalumikizidwa ndi matendawa (2).
Kafukufuku wosiyanasiyana awonetsa kuti DHA imatha kukhala ndi neuroprotective effect pochepetsa kawopsedwe ka beta-amyloid komanso popereka anti-inflammatory effect yomwe ingachepetse kupsinjika kwa amyloid plaque chifukwa cha okosijeni ndikuchepetsa kuchuluka kwa mapuloteni okhala ndi okosijeni ndi 57% (2).Ngakhale kusowa kwa DHA mwa odwala Alzheimer's kumatha kukhala ndi tanthauzo la momwe ma supplementation angawathandizire, ziyenera kudziwidwa kuti zowonjezera sizingachiritse izi kapena matenda aliwonse komanso maphunziro okhudza mutuwo akhala ndi zotsatira zosakanikirana.
Zowonjezera si mankhwala, ndipo zoona zake n'zakuti odwala a Alzheimer's okalamba adzapindula pang'ono ndi DHA kapena zakudya zina zopatsa thanzi kuti azithandizira chidziwitso chifukwa pofika nthawi yomwe amapezeka, kuwonongeka kwa thupi kwachitika kale ku ubongo.
Komabe, ofufuza ena akufufuza ngati DHA supplementation ingachedwetse kupitirira kwa chidziwitso.Itay Shafat Ph.D., wasayansi wamkulu wa gawo lazakudya ku Enzymotec, Ltd., wokhala ndi ofesi ya US ku Morristown, NJ, akutchula kafukufuku wa Yourko-Mauro et al.zomwe zinapeza, "Kuwonjezera kwa 900 mg / tsiku DHA kwa masabata a 24, kwa anthu okalamba> 55 omwe ali ndi kuchepa kwachidziwitso chapakati, adapititsa patsogolo kukumbukira kwawo ndi luso la kuphunzira" (4).
Ngakhale ogula ena sangaganize za thanzi lachidziwitso mpaka mavuto atabuka, ndizofunikira kuti ogulitsa azikumbutsa za kufunika kwa DHA kwa ubongo moyo wonse.M'malo mwake, DHA imatha kuthandizira thanzi lachidziwitso la achinyamata omwe ali ndi thanzi labwino komanso alibe vuto lodziwika bwino lazakudya.Kuyesa kwaposachedwa kosasinthika kochitidwa ndi Stonehouse et al., powerenga 176 achikulire athanzi azaka zapakati pa 18 mpaka 45, adapeza, "DHA supplementation idasintha kwambiri nthawi yamakumbukiro a episodic, pomwe kulondola kwa kukumbukira kwa episodic kunasinthidwa mwa akazi, komanso nthawi yochitira. kukumbukira ntchito kunakula mwa amuna” (5).Kuwongolera uku ali wamng'ono kungatanthauze thupi ndi malingaliro okonzekera bwino mavuto a ukalamba.
Alpha-linolenic acid (ALA) ndi omega-3, yomwe imachokera ku zomera monga chia ndi flaxseed m'malo mwa mafuta a m'nyanja.ALA ndi kalambulabwalo wa DHA, koma kutembenuka kwa masitepe angapo kuchokera ku ALA kupita ku DHA sikuthandiza mwa anthu ambiri, motero kumapangitsa kuti DHA yazakudya ikhale yofunika kwambiri pakuthandizira chidziwitso.ALA ili, komabe, ili ndi ntchito zina zofunika payokha.Herb Joiner-Bey, mlangizi wa zachipatala wa Barlean's, Ferndale, WA, akunena kuti ALA imagwiritsidwanso ntchito ndi maselo a ubongo kupanga mahomoni am'deralo, kuphatikizapo 'neuroprotectins,' ofunika kwambiri ku ubongo.Akuti ma neuroprotectins amapezekanso kuti ndi otsika mwa odwala a Alzheimer's komanso pakuyesa kwa labotale, ALA idawonedwa kuti ndiyofunikira pakukula kwaubongo.
Zomwe muyenera kuziganizira mukamamwa zowonjezera za DHA ndi mlingo komanso bioavailability.Anthu ambiri samapeza DHA yokwanira pazakudya zawo ndipo angapindule ndikumwa mowa wambiri kapena wokwera kwambiri.Kufunika kwa mlingo kudawonekera posachedwa mu kafukufuku wazaka zisanu ndi Chew et al.zomwe sizinapeze kusiyana kwakukulu mu ntchito yachidziwitso panthawi ya omega-3 supplementation mu maphunziro okalamba (zaka zapakati: 72) ndi zaka zokhudzana ndi macular degeneration.Akatswiri ambiri a kadyedwe kake anali kukayikira kapangidwe ka kafukufukuyu.Mwachitsanzo, a Jay Levy, director of sales Wakunaga of America Co., Ltd., Mission Viejo, CA, adati, "Chigawo cha DHA chinali 350 mg kokha pomwe kuwunika kwaposachedwa kwapeza kuti DHA tsiku lililonse mlingo wopitilira 580 mg umayenera perekani mapindu a ntchito yachidziwitso" (6).
Douglas Bibus, Ph.D., membala wa board alangizi asayansi ku Coromega, Vista, CA, adatchulapo nkhani ya Global Organisation for EPA ndi DHA Omega-3s (GOED) yotchedwa “Omega-3s and Cognition: Dosage Matters.”Gululo lidapeza, "atafufuza maphunziro a 20 okhudzana ndi chidziwitso omwe adachitika m'zaka zapitazi za 10, maphunziro okha omwe amapereka 700 mg ya DHA kapena kupitilirapo patsiku adawonetsa zotsatira zabwino" (7).
Mitundu ina yobweretsera imatha kupangitsa kuti mafuta am'madzi azitha kuyamwa.Mwachitsanzo, Andrew Aussie, wachiwiri kwa wachiwiri kwa purezidenti komanso mkulu wogwira ntchito ku Coromega, akuti kampani yake imagwira ntchito mwapadera, "zowonjezera za omega-3 zomwe zimapereka kuyamwa bwino kwa 300%.Malinga ndi kafukufuku wa Raatz et al.kuti Aussie akutchula, lipid emulsification m'mimba ndi sitepe yofunika kwambiri pa chimbudzi cha mafuta "kudzera m'badwo wa mawonekedwe a lipid-madzi ofunikira kuti agwirizane pakati pa lipases osungunuka ndi madzi osasungunuka" (8).Chifukwa chake, pothira mafuta a nsomba, njirayi imalambalalitsidwa, kukulitsa kuyamwa kwake (8).
Chinanso chomwe chimakhudza bioavailability ndi mawonekedwe a molekyulu a omega-3.Chris Oswald, DC, CNS, membala wa advisory board ku Nordic Naturals, Watsonville, CA, amakhulupirira kuti mawonekedwe a triglyceride a omega-3s ndi othandiza kwambiri pakukweza seramu yamagazi kuposa matembenuzidwe opangidwa.Poyerekeza ndi mamolekyu opangidwa ndi ethyl ester-bound molecule, mawonekedwe achilengedwe a triglyceride samva kugayidwa kwa enzymatic, zomwe zimapangitsa kuti 300% itengeke kwambiri (2).Chifukwa cha kapangidwe kake ka mamolekyu amafuta atatu amafuta omwe amamangiriridwa ku msana wa glycerol, mafuta a nsomba akagayidwa, mafuta ake amasinthidwa kukhala mafuta amtundu umodzi.Atatha kuyamwa kudzera m'maselo a epithelial, amasinthidwa kukhala triglycerides.Izi zimatheka chifukwa cha msana wa glycerol womwe ulipo, womwe ethyl ester sangakhale nawo (2).
Makampani ena amakhulupirira kuti omega-3s omangidwa ndi phospholipid amathandizira kuyamwa.Cheryl Meyers, mkulu wa zamaphunziro ndi zasayansi ku EuroPharma, Inc., Greenbay, WI, akuti kamangidwe kameneka "simagwira ntchito ngati njira yoyendetsera omega-3s, komanso imapereka chithandizo champhamvu muubongo paokha."Myers akufotokoza chowonjezera chimodzi kuchokera ku kampani yake yomwe imapereka phospholipid-bound omega-3s yotengedwa ku mitu ya salimoni (Vectomega).Chowonjezeracho chilinso ndi ma peptides omwe amakhulupirira kuti "amateteza mitsempha yamagazi muubongo polimbana ndi kuwonongeka kwa okosijeni."
Pazifukwa zofanana, makampani ena amasankha kupanga ndi mafuta a krill, gwero lina la phospholipid-bound omega-3s omwe amapereka bioavailability wabwino chifukwa cha kusungunuka kwawo m'madzi.Lena Burri, wotsogolera zolemba zasayansi ku Aker Biomarine Antarctic AS, Oslo, Norway, akupereka kufotokozeranso chifukwa chake mtundu uwu wa DHA ndi wofunikira kwambiri: imodzi "DHA transporter (Mfsd2a, main facilitator super family domain yomwe ili ndi 2a) ... imavomereza DHA pokhapokha ngati imamangiriridwa ku phospholipids - kukhala yeniyeni kwa lysoPC "(9).
Kafukufuku wina wosasinthika, wakhungu, wakhungu, wofananira m'magulu ofananirako adayesa zotsatira za mafuta a krill, mafuta a sardine (mawonekedwe a triglyceride) ndi placebo pakukumbukira kukumbukira ndi ntchito zowerengera mwa amuna achikulire a 45 azaka kuyambira 61-72 kwa milungu 12.Poyesa kusintha kwa kuchuluka kwa oxyhemoglobin panthawi yantchito, zotsatira zake zidawonetsa kusintha kwakukulu munjira inayake pambuyo pa milungu 12 kuposa placebo, kutanthauza kuti kuphatikizika kwanthawi yayitali kwa mafuta a krill ndi sardine "kumathandizira kukumbukira kukumbukira poyambitsa dorsolateral prefrontal cortex mwa okalamba. anthu, motero amalepheretsa kuwonongeka kwa chidziwitso "(10).
Komabe, ponena za ntchito zowerengera, mafuta a krill "amawonetsa kusintha kwakukulu kwa kuchuluka kwa oxyhemoglobin kumanzere chakumanzere chakumanzere," poyerekeza ndi mafuta a placebo ndi sardine, omwe sanawonetse zotsatira zilizonse panthawi yowerengera (10).
Kupatulapo kuthandizira kuyamwa kwa omega-3s, ma phospholipids amatenga gawo lofunikira pa thanzi lachidziwitso pawokha.Malinga ndi Burri, phospholipids amapanga pafupifupi 60% ya ubongo ndi kulemera kwake, makamaka olemeretsedwa mu dendrites ndi synapses.Kuphatikiza pa izi, akuti mu vitro, kukula kwa mitsempha kumapangitsa kuti pakhale kufunikira kowonjezereka kwa phospholipids komanso kukula kwa mitsempha kumalimbikitsa m'badwo wa phospholipid.Kuphatikizika ndi phospholipids kumagwiritsidwa ntchito kwambiri komanso kothandiza pothandizira chidziwitso chifukwa kapangidwe kake ndi kofanana ndi komwe kamakhala m'mitsempha.
Ma phospholipids awiri omwe amapezeka ndi phosphatidylserine (PS) ndi phosphatidylcholine (PC).Shafat akuti PS ili ndi zovomerezeka zovomerezeka ndi US Food and Drug Administration (FDA).Zonenazo zikuphatikiza: "Kugwiritsa ntchito PS kumatha kuchepetsa chiwopsezo cha dementia kwa okalamba," "Kugwiritsa ntchito PS kungachepetse chiopsezo cha kusokonezeka kwa chidziwitso mwa okalamba," komanso oyenerera, "Kafukufuku wocheperako komanso woyambirira wasayansi akuwonetsa kuti PS ikhoza kuchepetsa chiopsezo. za dementia/kuchepetsa chiopsezo cha kusokonezeka kwa chidziwitso mwa okalamba.A FDA atsimikiza kuti pali umboni wochepa wa sayansi wotsimikizira izi. "
Shafat akufotokoza kuti paokha, PS "imagwira ntchito kale pa mlingo wa 100 mg / tsiku," ndalama zochepa kusiyana ndi zosakaniza zina zothandizira chidziwitso.
Ponena za ntchito yake, Chase Hagerman, mkulu wa brand ku ChemiNutra, White Bear Lake, MN, akuti PS "imathandizira mapuloteni omwe amayendetsa ntchito za nembanemba zomwe zimakhudzidwa ndi kutumiza mauthenga a molekyulu kuchokera ku selo kupita ku selo, kumathandiza kuti zakudya zilowe m'maselo, ndikuthandizira . zinyalala zoipa zokhudzana ndi kupsinjika maganizo kuti zituluke mu selo. "
PC, kumbali ina, monga yomwe inapangidwa kuchokera ku alpha-glyceryl phosphoryl choline (A-GPC), Hagerman akuti, "imasamukira ku mapeto a mitsempha ya synaptic yomwe imapezeka m'kati mwa dongosolo lonse la mitsempha, ndipo imawonjezera kaphatikizidwe ndi kumasulidwa kwa acetylcholine (AC)," yomwe ndi neurotransmitter yofunika kwambiri "yomwe imapezeka muubongo ndi minofu," imagwira ntchito yofunika kwambiri "makamaka ntchito iliyonse yachidziwitso pomwe mu minofu imakhudzidwa kwambiri ndi kukangana kwa minofu."
Zinthu zosiyanasiyana zimagwira ntchito imeneyi.Dallas Clouatre, Ph.D., R&D consultant ku Jarrow Formulas, Inc., Los Angeles, CA, amawafotokoza ngati "banja lokulirapo la gawo limodzi," lomwe limaphatikizapo uridine, choline, CDP-choline (Citocoline) ndi PC monga mbali ya ubongo yomwe nthawi zina imatchedwa Kennedy Cycle.Zinthu zonsezi zimagwira ntchito popanga PC muubongo ndikupanga AC.
Kupanga kwa AC ndichinthu chinanso chomwe chimachepa tikamakalamba.Komabe, nthawi zambiri, chifukwa ma neuron sangapange choline yawoyawo ndipo amayenera kuilandira kuchokera m'magazi, zakudya zopanda choline zimapangitsa kuti AC (2) ikhale yosakwanira.Kuperewera kwa choline komwe kulipo kumathandizira pakukula kwa matenda monga Alzheimer's komanso kuchepa kwa chidziwitso chokhudzana ndi zaka.Ntchito ya wofufuza Richard Wurtman, MD, wochokera ku Massachusetts Institute of Technology yasonyeza kuti chifukwa cha choline chochepa, ubongo ukhoza kupha PC kuchokera ku neural neural membrane kupanga AC (2).
Neil E. Levin, CCN, DANLA, woyang'anira maphunziro a zakudya pa NOW Foods, Bloomingdale, IL akufotokoza ndondomeko "yomwe imathandizira kukhala maso ndi kuphunzira mwa kulimbikitsa kupanga AC yoyenera ndi ntchito," mwa kuphatikiza A-GPC, "mtundu wa bioavailable wa choline." ,” ndi Huperzine A kuti asunge ma AC (RememBRAIN kuchokera ku NOW Foods).Huperzine A amasunga AC pogwira ntchito ngati choletsa chosankha cha acetylcholinesterase, chomwe ndi puloteni yomwe imayambitsa kuwonongeka kwa AC (11).
Malinga ndi Levy, citicoline ndi imodzi mwazinthu zatsopano zothandizira kuzindikira, kulunjika kutsogolo kwa lobe, komwe ndi gawo lomwe limayang'anira kuthetsa mavuto, chidwi komanso kukhazikika.Ananenanso kuti kuphatikizika ndi citicoline mwa achikulire kwawonetsa "kupititsa patsogolo kukumbukira mawu, kukumbukira kukumbukira komanso kuzindikira, nthawi yayitali, kuthamanga kwa magazi ku ubongo ndi ntchito yamagetsi."Amatchulapo maphunziro angapo omwe awonetsa zotsatira zabwino, kuphatikiza kuyesa kwakhungu kawiri, kosasinthika, koyendetsedwa ndi placebo kwa odwala 30 a Alzheimer's omwe adawonetsa bwino chidziwitso chazidziwitso poyerekeza ndi placebo atatenga citicoline tsiku lililonse, makamaka pakati pa omwe ali ndi vuto la dementia pang'ono (12).
Elyse Lovett, woyang'anira zamalonda ku Kyowa USA, Inc., New York, NY, akuti kampani yake ili ndi "mtundu wokhawo wophunzitsidwa bwino wa citicoline mwa akulu ndi achinyamata athanzi," ndikuti "ndiwo mtundu wokhawo wa citicoline wokhala ndi GRAS [nthawi zambiri. odziwika ngati otetezeka] ku United States” (Cognizin).
Zina zowonjezera, malinga ndi Dan Lifton, pulezidenti wa Maypro's Proprietary Branded Ingredients Group, Purchase, NY, ndi INM-176 yochokera ku muzu Angelica gigas Nakai, yomwe yasonyezedwanso kuti imathandizira thanzi lachidziwitso poonjezera milingo ya ubongo wa AC.
Kuperewera kwa vitamini nthawi zambiri kumabwera chifukwa cha kuchepa kwa chidziwitso.Kuperewera kwa Vitamini B12, mwachitsanzo, kungaphatikizepo zizindikiro monga kusokonezeka, kukumbukira kukumbukira, kusintha kwa umunthu, paranoia, kuvutika maganizo ndi makhalidwe ena omwe amafanana ndi dementia.Osati zokhazo, koma 15% ya okalamba komanso 40% ya anthu omwe ali ndi zizindikiro zopitirira zaka 60 ali ndi ma B12 otsika kapena am'malire (13).
Malinga ndi Mohajeri et al., B12 imagwira ntchito yofunika kwambiri pakusintha homocysteine (Hcy) kukhala amino acid methionine, koma mavitamini ena a B a folate (B9) ndi B6 ndizofunikira kuti metabolic ichitike, popanda izi, Hcy amadziunjikira.Hcy ndi amino acid yomwe imapangidwa m'thupi kuchokera ku zakudya za methionine ndipo ndiyofunikira kuti ma cell azigwira bwino ntchito, koma kuchuluka kwake kumalepheretsa kugwira ntchito kwake (14).Michael Mooney, mkulu wa sayansi ndi maphunziro ku SuperNutrition, Oakland, CA anati:
Mohajeri et al.amachirikiza mawu awa: “Kuwopsa kwa kuwonongeka kwa chidziwitso kwalumikizidwa ndi kuchuluka kwa plasma Hcy.Kuphatikiza apo, chiopsezo chachikulu cha matenda a Alzheimer's chidanenedwa pomwe ma folate ndi B12 anali otsika "(15).
Niacin ndi vitamini B wina yemwe amathandizira kukumbukira ndi kuzindikira.Malinga ndi Mooney, niacin, mawonekedwe amphamvu kwambiri a vitamini B3, nthawi zambiri amaperekedwa ndi madokotala pa 1,000 mg kapena kupitilira apo patsiku kuti athandizire kuchuluka kwa cholesterol yabwinobwino, koma kafukufuku woyendetsedwa ndi placebo adapeza kuti kudya kwa 425 mg patsiku kumalimbitsa kukumbukira. mayeso ochuluka mpaka 40% komanso kuwongolera kaundula wamalingaliro ndi 40%.Pamphamvu zapamwamba, niacin ikuwonetsedwanso kuti imapangitsa kuti magazi aziyenda bwino, "zomwe zimawonjezera kufalikira kwa michere ndi mpweya mu ubongo," akuwonjezera (16).
Kuphatikiza pa niacin, Mooney amafotokoza za niacinamide, womwe ndi mtundu wina wa vitamini B3.Pa 3,000 mg/tsiku, niacinamide ikuphunziridwa ndi UC Irvine ngati chithandizo chotheka cha Alzheimer's ndi kukumbukira kukumbukira komwe kumalumikizidwa ndi zotsatira zabwino mu kafukufuku wa mbewa.Mitundu yonse iwiriyi, akufotokoza, imatembenuza m'thupi kukhala NAD +, molekyulu yomwe yawonetsedwa kuti imasintha ukalamba mu mitochondria, wopanga mphamvu zama cell zofunika kwambiri."Izi ndizofunikira kwambiri pakukulitsa kukumbukira kwa vitamini B3 ndi zotsatira zina zoletsa kukalamba," akutero.
Chowonjezera china chopangira makasitomala ndi PQQ.Clouatre ananena kuti ena amati ndi vitamini yekhayo watsopano amene anapezeka m’zaka makumi angapo zapitazi, ndipo zimenezi zikusonyeza zotsatira zabwino m’madera monga chitetezo cha m’thupi."PQQ imapondereza m'badwo wochuluka wa ma radicals angapo, kuphatikiza zoopsa kwambiri za peroxynitrite radical," akutero, ndipo mu PQQ yawonetsa zotsatira zabwino pakuphunzira ndi kukumbukira m'maphunziro a nyama ndi anthu.Chiyeso chimodzi chachipatala chinapeza kuti kuphatikiza kwa 20 mg ya PQQ ndi CoQ10 kunapereka phindu lalikulu m'mitu ya anthu kukumbukira, chidwi ndi kuzindikira (17).
Lifton akuti ngati niacin, PQQ ndi CoQ10 amathandizira ntchito ya mitochondrial.Akuti CoQ10 imachita izi poteteza "mitochondria makamaka kuti isawonongeke chifukwa cha kuukira kosalekeza kosalekeza," komanso kukulitsa "kupanga mphamvu zama cell, zomwe zingapangitse kuti mphamvu zambiri zizipezeka pazidziwitso."Izi ndizofunikira chifukwa "kafukufuku watsopano wosangalatsa akuwonetsa kuti chimodzi mwazinthu zomwe zimayambitsa vuto la kukumbukira pang'ono lomwe limakhudzana ndi ukalamba ndikuwonongeka kwa mitochondria yathu," akutero Lifton.
Magnesium ndi mchere wofunikira kuti ukhalebe ndi chidziwitso chabwino, kapena chifukwa chake, kugwira ntchito kwa thupi lonse.Malinga ndi Carolyn Dean, MD, ND, membala wa board advisory board wa Nutritional Magnesium Association, "Magnesium yokha ndiyofunikira mu 700-800 machitidwe osiyanasiyana a enzyme" ndi "ATP (adenosine triphosphate) kupanga mu Krebs kumadalira magnesiamu kwa zisanu ndi chimodzi. makwerero ake asanu ndi atatu.”
Kutsogolo kwachidziwitso, Dean akuti magnesium imatsekereza kutupa kwa neuro-ku chifukwa cha ma depositi a calcium ndi zitsulo zina zolemera m'maselo a ubongo komanso kuteteza njira za ion ndikutsekereza zitsulo zolemera kuti zisalowe.Akufotokoza kuti magnesium ikachepa, calcium imalowa mwachangu ndikupangitsa kuti maselo afe.Levin akuwonjezera kuti, "Kafukufuku waposachedwapa wasonyeza kuti ndizofunikira kwambiri pa thanzi labwino laubongo komanso kugwira ntchito bwino kwachidziwitso posunga kachulukidwe ndi kukhazikika kwa ma neuronal synapses."
M’buku lake lakuti The Magnesium Miracle, Dean akufotokoza kuti kupereŵera kwa magnesiamu kokha kungayambitse zizindikiro za dementia.Izi ndizowona makamaka tikamakalamba, popeza mphamvu ya thupi yotengera magnesiamu m'zakudya zathu imachepa ndipo imathanso kuletsedwa ndi mankhwala omwe amapezeka mwa okalamba (18).Chifukwa chake, kuchuluka kwa magnesiamu m'magazi kumatha kuchepa chifukwa thupi silingathe kuyamwa mchere, zakudya zosafunikira komanso mankhwala, kupanga calcium ndi glutamate mochulukirapo (makamaka ngati kudya zakudya zambiri za MSG), zonse zomwe zili ndi gawo lofunikira. mu kuwonongeka kwa neural kosatha komanso kukula kwa dementia (19).
Ngakhale kuti zakudya ndizofunikira kwambiri kuti mukhale ndi thanzi labwino lachidziwitso, zothandizira zitsamba zingaperekenso chithandizo chowonjezera muzosiyanasiyana.Kutsika kwachidziwitso kwa zaka zokhudzana ndi zaka komanso kusokonezeka maganizo kungapangidwe m'njira zosiyanasiyana, ndi kuchepa kwa magazi a ubongo kukhala imodzi mwa njira zosiyana kwambiri.Zitsamba zingapo zimagwira ntchito kuthana ndi izi.Tiyenera kuzindikira kuti zitsamba zomwe zimathandizira kuti magazi aziyenda bwino zingakhale zoopsa kwa makasitomala omwe akumwa kale mankhwala ochepetsa magazi monga warfarin.
Udindo waukulu wa Gingko biloba ndikuwonjezera kuyenda kwa magazi muubongo, komwe kumathandizira kwambiri kukula kwa dementia kaya kumayamba ndi matenda a Alzheimer's kapena cerebrovascular disease.Zimanenedwanso kuti zibwezeretsanso ntchito ya mitochondrial yosokonekera kuti ipititse patsogolo mphamvu za neuronal, kuonjezera kutengeka kwa choline mu hippocampus, kuletsa kuphatikizika ndi kawopsedwe ka mapuloteni a b-amyloid komanso kukhala ndi antioxidant zotsatira (20, 21).
Levy akutchula kafukufuku woyendetsa ndege wa milungu inayi mu Neuroradiology yemwe "adawonetsa kuwonjezeka kwa anayi mpaka asanu ndi awiri peresenti ya magazi a ubongo pa mlingo wochepa wa 120 mg patsiku" wa gingko (22).Kafukufuku wosiyana wosasinthika, woyendetsedwa ndi placebo, wakhungu kawiri wowonetsa mphamvu ndi chitetezo cha gingko biloba kwa odwala omwe ali ndi vuto lozindikira komanso zizindikiro za neuropsychiatric (NPS) lolemba Gavrilova et al., adapeza kuti "panthawi ya chithandizo cha masabata 24, kusintha kwa NPS ndi luso lachidziwitso kunali kwakukulu ndipo nthawi zonse kunkadziwika kwambiri kwa odwala omwe amamwa 240 mg patsiku la G. biloba kuchotsa EGb 761 kuposa odwala omwe amatenga placebo "(23).
Mphamvu ya gingko biloba ikuyesedwa ngakhale pazinthu zina monga kusokonezeka kwa chidwi (ADHD) mwa ana.Phunziro limodzi lochepa koma lodalirika la Sandersleben et al.Adanenanso kuti atawonjezera ndi gingko, "kusintha kwakukulu kunapezeka pakuwunika kwa makolo kutcheru kwa ana awo ... .Chifukwa cha zolephera za phunziroli, monga kusakhala ndi chiwongolero kapena chitsanzo chachikulu, palibe mfundo yotsimikizika yomwe ingaganizidwe pakuchita bwino kwake, koma mwachiyembekezo idzalimbikitsa kuyesedwa kosasinthika, kowongolera.
Chitsamba china chomwe chimagwira ntchito mofananamo ndi Bacopa monniera chomwe, malinga ndi Levy, kafukufuku waposachedwapa wa zinyama mu Phytotherapy Research anasonyeza "25% kuwonjezeka kwa magazi kupita ku ubongo pakati pa nyama zomwe zimatenga 60 mg ya bacopa monniera tsiku lililonse poyerekeza ndi kusawonjezeka kwa zomwe zapatsidwa donepezil. ” (25).
Amanenedwanso kuti ali ndi antioxidant katundu.Malinga ndi a Shaheen Majeed, wotsogolera zamalonda wa Sabinsa Corp., East Windsor, NJ, bacopa "imalepheretsa lipid peroxidation ndipo motero imalepheretsa kuwonongeka kwa ma cortical neurons."Lipid peroxidation imachitika panthawi ya kupsinjika kwa okosijeni komwe kumalumikizidwa ndi kusowa kwa DHA, komwe kumakhalanso chizindikiro cha Alzheimer's.
Mary Rove, ND, mphunzitsi wa zachipatala ku Gaia Herb, Brevard, NC, akutchulanso kuwonjezera zowonjezera zawo za Gingko ndi zitsamba monga peppermint ndi rosemary.Malinga ndi iye, peppermint imathandizira kukhala tcheru ndipo "kafukufuku wathandizira pa rosmaranic acid, chinthu chomwe chili ndi antioxidant katundu."Iye akuwonjezera kuti, “pali zambiri zamakono zosunga mawu aang’ono akuti ‘rosemary chikumbutso.’”
Huperzine A, wotchulidwa poyamba chifukwa cha ntchito yake monga acetylcholinesterase inhibitor, amachokera ku zitsamba zaku China Huperzia serrata.Kuthekera kwake poletsa kuwonongeka kwa acetylcholine ndikofanana ndi mankhwala ovomerezeka a FDA omwe amavomerezedwa kuti azitha kuchiza matenda a Alzheimer's kuphatikiza donepezil, galantamine ndi rivastigmine, omwe ndi cholinesterase inhibitors (11).
Kusanthula kwa meta kochitidwa ndi Yang et al.anamaliza, "Huperzine A ikuwoneka kuti ili ndi zotsatira zopindulitsa pakusintha kwachidziwitso, zochita za tsiku ndi tsiku komanso kuunika kwachipatala padziko lonse kwa omwe ali ndi matenda a Alzheimer's."Iwo anachenjeza, komabe, kuti zomwe zapezedwa ziyenera kutanthauziridwa mosamala chifukwa cha kusayenda bwino kwa njira zamayesero omwe akuphatikizidwa, ndikuyitanitsa mayesero owonjezera okhwima (11).
Antioxidants.Zambiri mwazowonjezera zomwe zimakambidwa zili ndi mphamvu za antioxidant, zomwe zimathandiza kuti zikhale zogwira mtima polimbana ndi kusokonezeka kwa chidziwitso, zomwe kupsinjika kwa okosijeni nthawi zambiri kumathandizira.Meyers anati: “Pafupifupi matenda onse a mu ubongo, kutupa n’kofunika kwambiri—kumasintha mmene maselo amagwirira ntchito limodzi.Ndicho chifukwa chake pakhala pali kuwonjezeka kotereku kutchuka ndi kufufuza kwa curcumin, yomwe ndi pawiri yomwe imachokera ku turmeric, yomwe ikuwonetsedwa kuti ichepetse kuwonongeka kwa kutupa ndi okosijeni mu ubongo ndikuthandizira kuwombera koyenera kwa ma neuroni, akutero Meyers.
Pankhani ya Alzheimer's, curcumin ikhoza kukhala ndi kuthekera kosokoneza kupanga kwa beta-amyloid.Kafukufuku wina wopangidwa ndi Zhang et al., yemwe adayesa curcumin pazikhalidwe zama cell ndi mbewa primary cortical neurons, adapeza kuti therere limachepetsa kuchuluka kwa beta-amyloid pochepetsa kusasitsa kwa amyloid-beta precursor protein (APP).Idachepetsa kukhwima kwa APP powonjezera kukhazikika kwa APP yosakhwima komanso kuchepetsa kukhazikika kwa APP yokhwima (26).
Kafukufuku wochulukirapo akufunika kuti amvetsetse bwino momwe curcumin angakhalire pa kuzindikira komanso momwe angathandizire kusokonezeka kwa chidziwitso.Pakadali pano, McCusker Alzheimer's Research Foundation ikuthandizira kafukufuku womwe ukuchitika ku yunivesite ya Edith Cowan ku Perth, Australia, kuyesa mphamvu ya curcumin kwa odwala omwe ali ndi vuto lochepa lachidziwitso.Kafukufuku wa miyezi 12 adzawunika ngati therere lidzasunga chidziwitso cha odwala.
Antioxidant ina yamphamvu yomwe imathandizira chidziwitso ndi Pycnogenol (yofalitsidwa ndi Horphag Research).Kupatula kukhala mphamvu yayikulu yolimbana ndi kuwonongeka kwa okosijeni, therere, lomwe limachokera ku khungwa la pine la ku France, lawonetsedwanso kuti limathandizira kufalikira kwa magazi, kuphatikiza microcirculation muubongo komanso kukulitsa kupanga nitric oxide, yomwe imakhala ngati neurotransmitter. , mwina zimathandizira kukumbukira ndi kuphunzira (25).Pakafukufuku wina wa milungu isanu ndi itatu, ofufuza adapatsa ophunzira 53 azaka zapakati pa 18 mpaka 27 Pycnogenol ndikuwunika momwe amachitira pamayeso enieni.Zotsatira zinasonyeza kuti gulu loyesera linalephera mayesero ochepa kusiyana ndi kulamulira (zisanu ndi ziwiri vs. 9) ndipo linachita 7.6% bwino kuposa kulamulira (27).WF
1. Joseph C. Maroon ndi Jeffrey Bost, Mafuta a Nsomba: Natural Anti-Inflammatory.Basic Health Publications, Inc. Laguna Beach, California.2006. 2. Michael A. Schmidt, Brian-Building Nutrition: Momwe Mafuta a Zakudya ndi Mafuta Amakhudzira Luntha la Maganizo, Thupi, ndi Emotional, Kope Lachitatu.Frog Books, Ltd. Berkeley, California, 2007. 3. J. Thomas et al., "Omega-3 mafuta ccids popewa kupewa matenda otupa a neurodegenerative: Kuganizira kwambiri za matenda a Alzheimer's."Hindawa Publishing Corporation, BioMed Research International, Volume 2015, ID ID 172801. 4. K. Yurko-Mauro et al., "Zotsatira zopindulitsa za docosahexaenoic acid pa kuzindikira mu kuchepa kwa chidziwitso cha zaka."Alzheimers Dement.6(6): 456-64.2010. 5. W. Stonehouse et al., "DHA supplementation inathandiza kukumbukira komanso nthawi yochita zinthu mwa achinyamata athanzi: mayesero oyendetsedwa mwachisawawa."Ndine J Clin Nutr.97: 1134-43 .2013. 6. EY Chew et al., "Zotsatira za omega-3 fatty acids, lutein/zeaxanthin, kapena zakudya zina zowonjezera zokhudzana ndi chidziwitso: mayesero achipatala a AREDS2."JAMA.314(8): 791-801.2015. 7. Adam Ismail, "Omega-3s and cognition: dosing matters."http://www.goedomega3.com/index.php/blog/2015/08/omega-3s-and-cognition-dosage-matters.8. Susan K. Raatz et al., "Kuwonjezera kuyamwa kwamafuta a omega-3 kuchokera ku emulsified poyerekeza ndi mafuta a nsomba."J Am Diet Assoc.109 (6).1076-1081.2009. 9. LN Nguyen et al., "Mfsd2a ndi chotengera cha omega-3 fatty acid docosahexaenoic acid."http://www.nature.com/nature/journal/v509/n7501/full/nature13241.html 10. C. Konagai et al., "Zotsatira za mafuta a krill omwe ali ndi n-3 polyunsaturated fatty acids mu mawonekedwe a phospholipid pa ubongo waumunthu ntchito: kuyesa kosasinthika mwa odzipereka okalamba athanzi. "Clin Interv Kukalamba.8: 1247-1257.2013. 11. Guoyan Yang et al., "Huperzine A wa matenda a Alzheimer's: kuwunika mwadongosolo komanso kusanthula kwa mayeso azachipatala osasintha."PLoS ONE.8 (9).2013. 12. XA.Alvarez et al."Kafukufuku woyendetsedwa ndi placebo-akhungu kawiri ndi citicoline mu APOE genotyped Alzheimer's disease odwala: zotsatira za chidziwitso, ubongo wa bioelectrical ntchito ndi kuphulika kwa ubongo."Njira Zopeza Exp Clin Pharmacol.21(9):633-44.1999. 13. Sally M. Pacholok ndi Jeffrey J. Stuart.Itha kukhala B12: Epidemic of Misdiagnosis, Edition Yachiwiri.Quill Driver Books.Fresno, CA.2011. 14. M. Hasan Mohajeri et al., "Kusakwanira kwa mavitamini ndi DHA kwa okalamba: Zotsatira za ukalamba wa ubongo ndi matenda a maganizo a Alzheimer."Zakudya zopatsa thanzi.31: 261-75 .2015. 15. SM.Loriaux et al."Zotsatira za nicotinic acid ndi xanthinol nicotinate pamtima wamunthu m'magulu osiyanasiyana azaka.Maphunziro akhungu awiri. ”Psychopharmacology (Berl).867 (4): 390-5.1985. 16. Steven Schreiber, "Phunziro la Chitetezo cha Nicotinamide Kuchitira Matenda a Alzheimer's."https://clinicaltrials.gov/ct2/show/NCT00580931?term=nicotinamide+alzheimer%27s&rank=1.17. Koikeda T. et.al, "Pyrroloquinoline quinone disodium mchere umapangitsa kuti ubongo uzigwira ntchito bwino."Kufunsira kwa Zamankhwala ndi Njira Zatsopano Zochizira.48 (5): 519. 2011. 18. Carolyn Dean, Chozizwitsa cha Magnesium.Ballantine Books, New York, NY.2007. 19. Dehua Chui et al., "Magnesium mu matenda a Alzheimer's."Magnesium mu Central Nervous System.Yunivesite ya Adelaide Press.2011. 20. S. Gauthier ndi S. Schlaefke, "Kugwira ntchito ndi kulekerera kwa Gingko biloba kuchotsa Egb 761 mu dementia: kuwunika mwadongosolo ndi kusanthula kwa mayesero oyendetsedwa ndi placebo."Zothandizira Zachipatala mu Ukalamba.9: 2065-2077.2014. 21. T. Varteresian ndi H. Lavretsky, "Zachilengedwe ndi zowonjezera za kuvutika maganizo kwa akuluakulu ndi matenda a chidziwitso: kuwunika kafukufuku.Curr Psychiatry Rep. 6 (8), 456. 2014. 22. A. Mashayekh, et al., "Zotsatira za Ginkgo biloba pakuyenda kwa magazi muubongo zomwe zimayesedwa ndi kuchuluka kwa MR perfusion imaging: phunziro loyendetsa."Neuroradiology.53(3):185-91.2011. 23. SI Gavrilova, et al., "Kugwira ntchito ndi chitetezo cha Gingko biloba kuchotsa EGb 761 mu vuto lochepa lachidziwitso ndi zizindikiro za neuropsychiatric: mayesero osasinthika, oyendetsedwa ndi placebo, akhungu awiri, ambiri."Int J Geriatr Psychiatry.29:1087-1095.2014. 24. HU Sandersleben et al., "Gingko biloba kuchotsa EGb 761 mwa ana omwe ali ndi ADHD."Z. Kinder-Jugendpsychiatr.Psychother.42 (5): 337-347.2014. 25. N. Kamkaew, et al., "Bacopa monnieri imawonjezera magazi muubongo mu makoswe osadalira kuthamanga kwa magazi."Phytother Res.27(1):135-8.2013. 26. C. Zhang, et al., "Curcumin imachepetsa milingo ya amyloid-beta peptide pochepetsa kusasitsa kwa amyloid-beta precursor protein."J Biol Chem.285 (37): 28472-28480.2010. 27. Richard A. Passwater, Buku la Wogwiritsa Ntchito ku Pynogenol Nature's Most Versatile Supplement.Basic Health Publications, Laguna Beach, CA.2005. 28. R. Lurri, et al., "Pynogenol supplementation imapangitsa kuti chidziwitso, chidwi ndi ntchito zamaganizo zitheke bwino kwa ophunzira."J Neurosurgery Sci.58(4): 239-48.2014.
Lofalitsidwa mu WholeFoods Magazine January 2016
WholeFoods Magazine ndi chida chanu chokhazikika pazolemba zathanzi komanso zakudya zomwe zilipo, kuphatikiza moyo wopanda gluteni komanso nkhani zazakudya zowonjezera.
Cholinga cha nkhani zathu zaumoyo ndi zakudya ndikudziwitsa ogulitsa ndi ogulitsa zinthu zachilengedwe zaposachedwa kwambiri komanso nkhani zazakudya zowonjezera, kuti athe kugwiritsa ntchito mwayi watsopano ndikusintha mabizinesi awo.Magazini yathu imapereka chidziwitso chofunikira chokhudza magulu atsopano ndi omwe akubwera kumene, kuphatikiza sayansi yomwe imayambitsa zakudya zopatsa thanzi.
Nthawi yotumiza: Jun-20-2019