Bophelo ba rona bo susumetsoa ke lintho tse ngata.Bareki ba kanna ba se ke ba amahanya bophelo bo botle ba kelello le bophelo bo botle ba bona ka kakaretso, empa bophelo bo botle ba kelello, 'meleng le maikutlong bo hokahane haholo.Sena se bontšoa ka tsela eo likhaello tse fapaneng tsa phepo li ka bakang ho fokotseha ha ts'ebetso ea kelello (mohlala, B12 le magnesium).
E boetse e bonahala ha re ntse re tsofala.Ha re ntse re hōla, 'mele o khona ho monya limatlafatsi tse fokolang lijong, e leng se ka fellang ka bofokoli.Ho bonolo ho lahla ho lebala le ho hloka tlhokomelo e le matšoao a lilemo, tseo li leng tsona, empa hape ke matšoao a boemo bo akaretsang ba 'mele ea rona ka lebaka la botsofali.Tlatsetso, ka ho etsa khaello ea limatlafatsi, le eona e ka ntlafatsa ts'ebetso ea kelello.Mona ke limatlafatsi tse ikhethileng tse amanang le bophelo bo botle ba kelello.
Karolo e le 'ngoe ho tse tharo ea boko e entsoe ka polyunsaturated fatty acids (PUFA), e nkang karolo ea 15-30% ea boima bo omeletseng ba boko, 'me docosahexaenoic acid (DHA) e etsang karolo ea boraro ea (1).
DHA ke omega-3 fatty acid e bapalang karolo ea bohlokoa bokong, e tsepamisitse maikutlo likarolong tsa boko tse hlokang tekanyo e phahameng ka ho fetisisa ea ts'ebetso ea motlakase, ho kenyelletsa le li-synaptosomes moo methapo ea kutlo e kopanang le ho buisana le e mong, mitochondria, e hlahisang matla lisele tsa methapo, le cortex ea boko, e leng karolo e ka ntle ea boko (2).Ho hlakile hore DHA ke karolo ea bohlokoa bakeng sa kholo ea boko ba lesea le lesea 'me e bohlokoa bophelong bohle bakeng sa ho boloka bophelo bo botle ba kelello.Bohlokoa ba DHA ha re ntse re tsofala bo bonahala ha ho shejoa ba anngoeng ke ho fokotseha ho amanang le lilemo, joalo ka lefu la Alzheimer's (mofuta oa 'dementia' o bakang mohopolo o tsoelang pele, ho fokotseha ha kelello le boitšoaro).
Ho latela tlhahlobo ea Thomas et al., "Ho bakuli ba fumanoeng ba e-na le lefu la Alzheimer's, maemo a tlase haholo a DHA a ile a bonoa plasma ea mali le bokong.Sena ha se feela ka lebaka la ho ja lijo tse fokolang tsa omega-3 fatty acids, empa hape se ka bakoa ke ho eketseha ha oxidation ea PUFAs "(3).
Ho bakuli ba Alzheimer, ho fokotseha ha kelello ho nahanoa hore ho bakoa ke protheine beta-amyloid, e chefo ho lisele tsa methapo.Ha litekanyetso tsa protheine ena li e-ba ngata haholo, li senya likarolo tse kholo tsa lisele tsa boko, li siea li-amyloid plaque tse amanang le lefu lena (2).
Lithuto tse fapaneng li bonts'itse hore DHA e ka ba le phello ea neuroprotective ka ho fokotsa chefo ea beta-amyloid le ka ho fana ka phello e khahlanong le ho ruruha e ka fokotsang khatello ea mali e bakoang ke amyloid plaque le ho fokotsa maemo a liprotheine tse nang le oxidized ka 57% (2).Le hoja khaello ea DHA ho batho ba nang le lefu la Alzheimer e ka ba le liphello tse ling mabapi le hore na tlatsetso e ka ba tsoela molemo joang, ho lokela ho hlokomeloa hore li-supplement li ke ke tsa phekola lefu lena kapa lefu leha e le lefe le lithuto tse sebetsanang le sehlooho seo li bile le liphello tse tsoakaneng.
Litlatsetso ha se meriana, 'me' nete ke hore bakuli ba Alzheimer ba seng ba tsoetse pele lilemong ba tla rua molemo o fokolang ho tsoa ho DHA kapa li-nutraceuticals tse ling bakeng sa ts'ehetso ea kelello hobane nakong ea ha ba fumanoa, tšenyo ea 'mele e se e entsoe bokong.
Leha ho le joalo, bafuputsi ba bang ba ntse ba batlisisa hore na tlatsetso ea DHA e ka liehisa tsoelo-pele ea ho fokotseha ha kelello.Itay Shafat Ph.D., ramahlale e moholo oa lefapha la phepo e nepahetseng Enzymotec, Ltd., le ofisi ea US e Morristown, NJ, o qotsa thuto e entsoeng ke Yourko-Mauro et al.e fumaneng, "Ho tlatsetsoa ha 900 mg / letsatsi DHA bakeng sa libeke tsa 24, ho batho ba lilemo li> 55 ba nang le ho fokotseha ha kelello ka mokhoa o itekanetseng, ho ntlafatsa mohopolo oa bona le tsebo ea ho ithuta" (4).
Le hoja bareki ba bang ba ka 'na ba se ke ba nahana ka bophelo bo botle ba kelello ho fihlela mathata a hlaha, ke senotlolo sa barekisi ho ba hopotsa bohlokoa ba DHA bakeng sa boko bophelo bohle.Ebile, DHA e ka ts'ehetsa bophelo bo botle ba kelello ba bacha ba phetseng hantle 'me ba se na bofokoli bo hlakileng ba limatlafatsi.Teko ea morao-rao e laoloang ka mokhoa o sa reroang ke Stonehouse et al., ho ithuta batho ba baholo ba phetseng hantle ba 176 ba lilemo li 18 ho isa ho 45, ba fumane, "tlatsetso ea DHA e ntlafalitse haholo nako ea karabelo ea mohopolo oa episodic, athe ho nepahala ha mohopolo oa episodic ho ile ha ntlafatsoa ho basali, le nako ea karabelo. memori e sebetsang e ile ya ntlafala ho banna” (5).Ntlafatso ena ha motho a sa le monyenyane e ka fetolela 'mele le kelello e lokiselitsoeng hamolemo bakeng sa mathata a botsofali.
Alpha-linolenic acid (ALA) ke omega-3, eo hangata e fumanoang limela tse kang chia le flaxseed e le mokhoa o mong oa oli ea leoatleng.ALA ke selelekela sa DHA, empa phetoho ea mehato e mengata ho tloha ho ALA ho ea ho DHA ha e sebetse ho batho ba bangata, ka hona e etsa hore lijo tsa DHA e be tsa bohlokoa bakeng sa ts'ehetso ea kelello.Leha ho le joalo, ALA e na le mesebetsi e meng ea bohlokoa ka bo eona.Herb Joiner-Bey, moeletsi oa saense ea bongaka bakeng sa Barlean's, Ferndale, WA, o re ALA e boetse e, “e sebelisoa ke lisele tsa boko ho etsa lihomone tsa lehae, ho akarelletsa le ‘neuroprotectins,’ tse bohlokoa haholo tšebetsong ea boko.”O re li-neuroprotectins le tsona li fumanoa li le tlase ho bakuli ba Alzheimer le litekong tsa laboratori, ALA e nkuoe e le ea bohlokoa ntlafatsong ea boko.
Lintlha tse lokelang ho nahanoa ha u nka li-supplement tsa DHA ke litekanyetso le bioavailability.Batho ba bangata ha ba fumane DHA e lekaneng lijong tsa bona mme ba ka rua molemo ka ho noa litekanyo tse matla haholo kapa tse phahameng.Bohlokoa ba litekanyetso bo sa tsoa hlakisoa thutong ea lilemo tse hlano ea Chew et al.e sa fumaneng phapang e kholo ea ts'ebetso ea kelello nakong ea tlatsetso ea omega-3 ho batho ba tsofetseng (bolemo bo bolelang: 72) ka ho senyeha ha macular ho amanang le lilemo.Litsebi tse ngata tsa phepo e nepahetseng li ne li belaela ka moralo oa thuto.Mohlala, Jay Levy, motsamaisi oa thekiso ea Wakunaga of America Co., Ltd., Mission Viejo, CA, o itse, "Karolo ea DHA e ne e le 350 mg feela, ha tlhahlobo ea morao-rao e fumane hore litekanyetso tsa letsatsi le letsatsi tsa DHA tse fetang 580 mg li ne li hlokahala. fana ka melemo ea ts'ebetso ea kelello "(6).
Douglas Bibus, Ph.D., setho sa boto ea boeletsi ba mahlale bakeng sa Coromega, Vista, CA, o qotsitse sengoloa sa Global Organisation for EPA le DHA Omega-3s (GOED) se bitsoang “Omega-3s and Cognition: Dosage Matters.”Sehlopha se fumane, ka mor'a "ho hlahloba lithuto tsa 20 tse thehiloeng kelellong tse entsoeng nakong ea lilemo tse fetileng tsa 10, ke lithuto tse fanang ka 700 mg ea DHA kapa ho feta ka letsatsi tse tlalehileng liphello tse ntle" (7).
Mefuta e meng ea thomello e ka etsa hore oli ea leoatleng e monye haholoanyane.Mohlala, Andrew Aussie, motlatsi oa motlatsi oa mopresidente le ofisiri e kholo ea ts'ebetso ea Coromega, o re k'hamphani ea hae e sebetsa ka ho khetheha, "litlatsetso tsa omega-3 tse kentsoeng tse fanang ka ho monya hantle ka 300%.Ho ea ka thuto ea Raatz et al.eo Aussie a e qotsang, lipid emulsification ka mpeng ke mohato oa bohlokoa oa tšilo ea mafura "ka ho hlahisa sebopeho sa lipid-metsi se hlokahalang bakeng sa ho sebelisana pakeng tsa lipases tse qhibilihisang metsi le li-insoluble lipids" (8).Ka hona, ka ho etsa emulsifying oli ea tlhapi, ts'ebetso ena e fetisoa, e ntlafatsa ho monya ha eona (8).
Ntho e 'ngoe e amang bioavailability ke mofuta oa limolek'hule oa omega-3.Chris Oswald, DC, CNS, setho sa boto ea boeletsi ho Nordic Naturals, Watsonville, CA, o lumela hore mofuta oa triglyceride oa omega-3s o sebetsa haholo ho phahamisa maemo a serum ea mali ho feta liphetolelo tsa maiketsetso.Ha ho bapisoa le limolek'hule tsa maiketsetso tsa ethyl ester-bound, mofuta oa tlhaho oa triglyceride ha o hanane le tšilo ea 'mele ea enzymatic, e etsa hore e fihle ho 300% e monyehang haholoanyane (2).Ka lebaka la sebopeho sa eona sa molek'hule sa li-acid tse tharo tsa mafura tse khomaretsoeng mokokotlong oa glycerol, ha oli ea tlhapi e siloa, lipid ea eona e fetoha li-acid tse mafura a mofuta o le mong.Kamora ho kenella ka har'a lisele tsa epithelial, li khutlisetsoa ho triglycerides.Sena se khoneha ka mokokotlo oa glycerol o fumanehang, oo ethyl ester e neng e ke ke ea e-ba le oona (2).
Lik'hamphani tse ling li lumela hore omega-3s e nang le phospholipid e tla ntlafatsa ho monya.Cheryl Meyers, mookameli oa thuto le litaba tsa saense EuroPharma, Inc., Greenbay, WI, o re mohaho ona “ha o sebetse feela e le mokhoa oa ho tsamaisa li-omega-3, empa hape o fana ka tšehetso e matla ea boko ka bobona.”Myers o hlalosa tlatsetso e le 'ngoe e tsoang k'hamphaning ea hae e fanang ka li-omega-3 tse nang le phospholipid tse nkiloeng lihloohong tsa salmon (Vectomega).Tlatsetso ena e boetse e na le li-peptide tseo a lumelang hore "li ka sireletsa methapo ea mali bokong ka ho loantša tšenyo ea oxidative."
Ka mabaka a tšoanang, lik'hamphani tse ling li khetha ho etsa ka oli ea krill, mohloli o mong oa omega-3 e nang le phospholipid e fanang ka bioavailability e ntle ka lebaka la ho qhibiliha ha metsi.Lena Burri, motsamaisi oa bongoli ba mahlale ho Aker Biomarine Antarctic AS, Oslo, Norway, o fana ka tlhaloso e eketsehileng ea hore na ke hobane'ng ha mofuta ona oa DHA o le bohlokoa hakana: "DHA transporter (Mfsd2a, mookameli ea ka sehloohong oa lelapa le nang le 2a) ... o amohela DHA feela haeba e tlameletsoe ho phospholipids-ho ba hantle ho lysoPC "(9).
Boithuto bo le bong bo sa reroang, bo sa boneng, bo sa boneng, bo nang le lihlopha tse tšoanang bo lekanyelitse litlamorao tsa oli ea krill, oli ea sardine (sebopeho sa triglyceride) le placebo mesebetsing ea mohopolo le lipalo ho banna ba baholo ba 45 ho tloha ho 61-72 bakeng sa libeke tse 12.Ka ho lekanya liphetoho tsa mahloriso a oxyhemoglobin nakong ea mesebetsi, liphetho li bonts'itse liphetoho tse kholo ho tsepamisa mohopolo mocha o itseng kamora libeke tse 12 ho feta placebo, ho fana ka maikutlo a hore tlatsetso ea nako e telele ea oli ea krill le sardine "e khothalletsa ts'ebetso ea mohopolo ka ho kenya tšebetsong dorsolateral prefrontal cortex ho batho ba tsofetseng. batho, kahoo e thibela ho senyeha ha ts'ebetso ea kelello "(10).
Leha ho le joalo, mabapi le mesebetsi ea lipalo, oli ea krill "e bonts'itse liphetoho tse kholo haholo maemong a oxyhemoglobin sebakeng se ka pele se ka letsohong le letšehali," ha se bapisoa le placebo le oli ea sardine, e neng e sa bonts'e litlamorao tsa ts'ebetso nakong ea lipalo (10).
Ntle le ho thusa ho monya ha omega-3s, phospholipids e bapala karolo ea bohlokoa ho bophelo bo botle ba kelello ka botsona.Ho ea ka Burri, phospholipids e etsa hoo e ka bang 60% ea boko ka boima ba 'mele, haholo-holo e ruisitsoeng ka dendrites le synapses.Ntle le sena, o re in vitro, kholo ea methapo e baka tlhoko e ntseng e eketseha ea phospholipids mme ntlha ea kholo ea methapo e hlohlelletsa moloko oa phospholipid.Tlatsetso ka phospholipids e sebelisoa haholo ebile e sebetsa hantle ho thusa ts'ebetso ea kelello hobane sebopeho sa bona se ts'oana le sa methapo ea kutlo.
Li-phospholipids tse peli tse tloaelehileng ke phosphatidylserine (PS) le phosphatidylcholine (PC).Shafat o re PS e na le likopo tse tšoanelehang tsa bophelo bo botle tse amohetsoeng ke US Food and Drug Administration (FDA).Litlaleho li kenyelletsa: "Tšebeliso ea PS e ka fokotsa kotsi ea 'dementia' ho batho ba tsofetseng," "Ho sebelisa PS ho ka fokotsa kotsi ea ho se sebetse hantle kelellong ho batho ba tsofetseng," 'me ba tšoaneleha ka, "Lipatlisiso tse fokolang haholo le tsa pele tsa saense li fana ka maikutlo a hore PS e ka fokotsa kotsi. ya dementia/fokotsa kotsi ya ho se sebetse hantle kelellong ho maqheku.FDA e etsa qeto ea hore ho na le bopaki bo fokolang ba saense bo tšehetsang taba ena.”
Shafat o hlalosa hore ka boeona, PS "e se e ntse e sebetsa ka tekanyo ea 100 mg / letsatsi," chelete e nyenyane ho feta metsoako e meng ea ts'ehetso ea kelello.
Mabapi le mosebetsi oa eona, Chase Hagerman, mookameli oa lihlahisoa tsa ChemiNutra, White Bear Lake, MN, o re PS "e thusa liprotheine tse laolang mesebetsi ea lera e amehang ho fetiseng melaetsa ea limolek'hule ho tloha seleng ho ea ho sele, e thusa limatlafatsi ho kena liseleng, 'me li thusa. lihlahisoa tse kotsi tse amanang le khatello ea maikutlo ho tsoa ka seleng. ”
PC, ka lehlakoreng le leng, e kang e entsoeng ho tloha ho alpha-glyceryl phosphoryl choline (A-GPC), Hagerman o re, "e fallela lipheletsong tsa methapo ea synaptic e fumanoang ho pholletsa le tsamaiso eohle ea methapo ea methapo, 'me ka lehlakoreng le leng e eketsa motsoako le ho lokolloa ha methapo ea kutlo. acetylcholine (AC)," e leng neurotransmitter ea bohlokoa "e teng bokong le mesifa ea mesifa," e bapala karolo ea bohlokoa "ha e le hantle ts'ebetso e 'ngoe le e 'ngoe ea kelello ha mesifa e ameha haholo ho honyeng ha mesifa."
Lintho tse fapaneng li sebetsa ho fihlela sena.Dallas Clouatre, Ph.D., moeletsi oa R&D ho Jarrow Formulas, Inc., Los Angeles, CA, o ba hlalosa e le "lelapa le atolositsoeng la karoloana e itseng," e kenyelletsang uridine, choline, CDP-choline (Citocoline) le PC joalo ka. karolo ea potoloho ea boko ka linako tse ling e bitsoa Kennedy Cycle.Lintho tsena kaofela li na le seabo ho theheng PC bokong le ho etsa synthesizing ea AC.
Tlhahiso ea AC ke ntho e 'ngoe hape e fokotsehang ha re ntse re tsofala.Leha ho le joalo, ka kakaretso, hobane li-neuron ha li khone ho hlahisa choline ea tsona 'me li tlameha ho e fumana maling, lijo tse haelloang ke choline li baka phepelo e sa lekaneng ea AC (2).Ho haella ha choline e fumanehang ho phetha karolo ea ho nts'etsapele mafu a kang Alzheimer's le ho fokotseha ha kelello ho amanang le lilemo.Mosebetsi oa mofuputsi Richard Wurtman, MD, oa Setsi sa Theknoloji sa Massachusetts o khothalelitse hore ka lebaka la choline e sa lekaneng, boko bo ka 'na ba ja PC ho tloha lera la eona la neural ho etsa AC (2).
Neil E. Levin, CCN, DANLA, mookameli oa thuto ea phepo e nepahetseng ho NOW Foods, Bloomingdale, IL e hlalosa tlhahiso "e tšehetsang ho falimeha kelellong le ho ithuta ka ho khothalletsa tlhahiso e nepahetseng ea AC le mosebetsi," ka ho kopanya A-GPC, "mofuta oa bioavailable oa choline. ,” ka Huperzine A ho boloka maemo a AC (RememBRAIN ho tloha NOW Foods).Huperzine A e boloka AC ka ho sebetsa e le inhibitor e khethiloeng ea acetylcholinesterase, e leng enzyme e bakang ho senyeha ha AC (11).
Ho ea ka Levy, citicoline ke e 'ngoe ea metsoako e mecha ea ho tšehetsa temoho, e lebisang lobe e ka pele, e leng sebaka se ikarabellang bakeng sa ho rarolla mathata, ho ela hloko le ho tsepamisa mohopolo.O re tlatsetso e nang le citicoline ho batho ba baholo ba baholo e bontšitse "ho ntlafatsa mohopolo oa mantsoe, ts'ebetso ea mohopolo le temoho, nako ea ho ela hloko, phallo ea mali bokong le ts'ebetso ea bioelectric."O qotsa liphuputso tse 'maloa tse bontšitseng liphello tse ntle, tse kenyeletsang teko e laoloang habeli, e sa reroang, e laoloang ke placebo ea bakuli ba 30 ba Alzheimer e bontšitseng ts'ebetso e ntlafetseng ea kelello ha e bapisoa le placebo ka mor'a ho noa citicoline letsatsi le leng le le leng, haholo-holo har'a ba nang le 'dementia' e bonolo (12).
Elyse Lovett, molaoli oa papatso Kyowa USA, Inc., New York, NY, o re k'hamphani ea hae e na le "mofuta feela o ithutoang ka bongaka oa citicoline ho batho ba baholo le bacha ba phetseng hantle," le hore "ke eona feela mofuta oa citicoline o nang le GRAS [ka kakaretso. ho amoheloa e le boemo bo sireletsehileng] United States” (Cognizin).
Tlatsetso e 'ngoe e amanang le eona, ho ea ka Dan Lifton, mopresidente oa Maypro's Proprietary Branded Ingredients Group, Purchase, NY, ke INM-176 e nkiloeng ho motso oa Angelica gigas Nakai, o bontšitsoeng hape ho tšehetsa bophelo bo botle ba kelello ka ho eketsa maemo a boko ba AC.
Khaello ea vithamine hangata e itlhahisa ka ho fokotseha ha tšebetso ea kelello.Ho haella ha vithamine B12, mohlala, ho ka kenyelletsa matšoao a kang pherekano, ho lahleheloa ke mohopolo, liphetoho tsa botho, ho ferekana kelellong, ho tepella maikutlong le mekhoa e meng e tšoanang le 'dementia'.Hase seo feela, empa 15% ea batho ba baholo le hoo e ka bang 40% ea batho ba nang le matšoao ho feta lilemo tse 60 ba na le maemo a tlaase kapa a moeli a B12 (13).
Ho ea ka Mohajeri et al., B12 e phetha karolo ea bohlokoa ho fetoleng homocysteine (Hcy) ho amino acid methionine, empa li-vithamine tse ling tsa B folate (B9) le B6 ke li-cofactors tse hlokahalang bakeng sa metabolization ho etsahala, ntle le eona, Hcy e bokella.Hcy ke amino acid e hlahisoang 'meleng ho tsoa ho methionine ea lijo mme e bohlokoa bakeng sa ts'ebetso e tloaelehileng ea lisele, empa bongata ba eona bo nyenyefatsa ts'ebetso e boletsoeng (14).Michael Mooney, motsamaisi oa saense le thuto oa SuperNutrition, Oakland, CA, o re: "Maemo a phahameng a mali a homocysteine a 'nile a sekisetsa mohopolo le likarolo tse ling tse' maloa tsa ts'ebetso ea kelello."
Mohajeri et al.e tiisa polelo ena: “Bothata ba ho holofala ha kelello bo ’nile ba amahanngoa le ho eketseha ha plasma Hcy.Ho feta moo, kotsi e kholo ea lefu la Alzheimer e tlalehiloe ha maemo a folate le B12 a le tlase ”(15).
Niacin ke vithamine B e 'ngoe e tšehetsang mohopolo le ts'ebetso ea kelello.Ho ea ka Mooney, niacin, mofuta o sebetsang haholoanyane oa vithamine B3, hangata o laeloa ke lingaka ho 1,000 mg kapa ho feta ka letsatsi ho tšehetsa maemo a tloaelehileng a k'holeseterole, empa thuto e laoloang ke placebo e fumane hore tekanyo ea phepo ea 425 mg ka letsatsi e ntlafalitse mohopolo. lintlha tsa teko ka hoo e ka bang 40% hammoho le ho ntlafatsa ngoliso ea maikutlo ka hoo e ka bang 40%.Ka matla a phahameng, niacin e boetse e bontšoa ho ntlafatsa phallo ea mali ea boko, "e leng ho eketsang ho potoloha ha limatlafatsi le oksijene bokong," o phaella ka ho re (16).
Ho phaella ho niacin, Mooney o hlalosa niacinamide, e leng mofuta o mong oa vithamine B3.Ka 3,000 mg / letsatsi, niacinamide e ntse e ithutoa ke UC Irvine e le phekolo e ka bang teng bakeng sa Alzheimer's le tahlehelo ea mohopolo e amanang le eona ka mor'a liphello tse ntle thutong ea mouse.O hlalosa hore mefuta ena ka bobeli e fetolela 'meleng ho NAD +, molek'hule e bonts'itsoeng ho khutlisa botsofali ho mitochondria, e leng moetsi oa matla oa cellular oa bohlokoa haholo.O re: "Ho ka etsahala hore sena se tlatselitse haholo ho matlafatseng mohopolo oa vithamine B3 le litlamorao tse ling tse thibelang botsofali.
Tlatsetso e 'ngoe ea ho khothaletsa bareki ke PQQ.Clouatre o re e nkoa ke ba bang e le eona feela vithamine e ncha e sibolotsoeng lilemong tse mashome a ’maloa tse fetileng, e bontšang liphello tse ntle libakeng tse kang neuroprotection."PQQ e hatella moloko o feteletseng oa li-radicals tse ngata, ho kenyelletsa le "peroxynitrite radical" e kotsi haholo, 'me ho PQQ e bontšitse liphello tse ntle ho ithuta le ho hopola lithutong tsa liphoofolo le tsa batho.Teko e 'ngoe ea bongaka e fumane hore motsoako oa 20 mg oa PQQ le CoQ10 o fane ka melemo e mengata lithutong tsa batho mohopolong, tlhokomelong le temohong (17).
Lifton o re joalo ka niacin, PQQ le CoQ10 li tšehetsa tšebetso ea mitochondrial.O re CoQ10 e etsa joalo ka ho sireletsa "mitochondria ka ho khetheha tšenyo e bakoang ke litlhaselo tse sa khaotseng tsa mahala," hammoho le ho eketsa "tlhahiso ea matla a cellular, e leng se ka etsang hore matla a mangata a fumanehe bakeng sa mekhoa ea kelello."Sena ke sa bohlokoa hobane "lipatlisiso tse ncha tse thabisang li fana ka maikutlo a hore e 'ngoe ea lisosa tse ka sehloohong tsa mathata a ho hopola hanyenyane a amanang le botsofali ke tšenyo ea mitochondria ea rona," ho bolela Lifton.
Magnesium ke diminerale ea bohlokoa bakeng sa ho boloka tšebetso e ntle ea kelello, kapa bakeng sa taba eo, tšebetso ea 'mele ka kakaretso.Ho ea ka Carolyn Dean, MD, ND, setho sa boto ea boeletsi ba bongaka ea Nutritional Magnesium Association, "Magnesium feela e hlokahala lits'ebetsong tse fapaneng tsa 700-800 tsa li-enzyme" le tlhahiso ea "ATP (adenosine triphosphate) potolohong ea Krebs e itšetlehile ka magnesium bakeng sa tse tšeletseng. ea mehato ea eona e robeli.”
Ka pel'a kelello, Dean o re magnesium e thibela neuro-inflammation e bakoang ke li-deposit tsa calcium le tse ling tse boima liseleng tsa boko hammoho le ho lebela likanale tsa ion le ho thibela litšepe tse boima ho kena.O hlalosa hore ha magnesium e le tlaase, calcium e kena ka sekhahla ’me e baka lefu la lisele.Levin o phaella ka ho re, "Lipatlisiso tsa morao-rao li bontšitse hore e bohlokoa hape bakeng sa bophelo bo botle ba boko le ts'ebetso e tloaelehileng ea kelello ka ho boloka botsitso le botsitso ba li-neuronal synapses."
Bukeng ea hae ea Magnesium Miracle, Dean o hlalosa hore khaello ea magnesium feela e ka baka matšoao a ho lahleheloa ke kelello.Sena ke 'nete haholo ha re ntse re tsofala, kaha matla a' mele a ho monya magnesium lijong tsa rona a fokotseha hape a ka sitisoa ke litlhare tse atileng ho batho ba tsofetseng (18).Kahoo, maemo a magnesium maling a ka fokotseha hobane 'mele o haelloa ke matla a ho monya liminerale, lijo tse fosahetseng le meriana, ho etsa hore ho be le calcium e ngata le glutamate (haholo-holo haeba u ja lijo tse ngata ho MSG), tseo ka bobeli li nang le karolo eo li lokelang ho e bapala. ho senyeha ha methapo e sa foleng le nts'etsopele ea 'dementia' (19).
Le ha limatlafatsi li le bohlokoa bakeng sa ho boloka ts'ebetso ea kelello e phetseng hantle, lithuso tsa litlama le tsona li ka fana ka ts'ehetso e eketsehileng ka bokhoni bo fapaneng.Ho fokotseha ha kelello ho amanang le lilemo le 'dementia' ho ka bōptjoa ka litsela tse sa tšoaneng, 'me ho fokotseha ha phallo ea mali ea boko e le e' ngoe ea mekhoa e khethollang ka ho fetisisa.Litlama tse 'maloa li sebetsa ho tobana le ntlha ena.Ho lokela ho hlokomeloa hore litlama tse ntlafatsang phallo ea mali li ka ba kotsi ho bareki ba seng ba ntse ba noa meriana e fokotsang mali e kang warfarin.
Karolo e ka sehloohong ea Gingko biloba ke ho eketsa phallo ea mali bokong, e bapalang karolo e kholo ho nts'etsopele ea 'dementia' ho sa tsotellehe hore na e bakoa ke lefu la Alzheimer's kapa cerebrovascular disease.Ho boetse ho boleloa hore e tsosolosa ts'ebetso ea mitochondrial e senyehileng ho ntlafatsa phepelo ea matla a neuronal, ho eketsa ho kenngoa ha choline ho hippocampus, ho thibela ho bokellana le chefo ea protheine ea b-amyloid le ho ba le liphello tsa antioxidant (20, 21).
Levy o qotsa phuputso ea lifofane ea libeke tse 'nè ho Neuroradiology "e senotseng keketseho ea liperesente tse 'nè ho isa ho tse supileng tsa phallo ea mali ea boko ka tekanyo e itekanetseng ea 120 mg ka letsatsi" ea gingko (22).Boithuto bo fapaneng bo sa reroang, bo laoloang ke placebo, bo foufetseng habeli bo bontšang katleho le polokeho ea gingko biloba ho bakuli ba nang le bokooa bo bobebe ba kelello le matšoao a neuropsychiatric (NPS) ke Gavrilova et al., e fumane hore "nakong ea kalafo ea libeke tse 24, lintlafatso tsa NPS le bokhoni ba kelello li ne li le bohlokoa 'me li ne li tsebahala haholo ho bakuli ba nkang 240 mg ka letsatsi ea G. biloba extract EGb 761 ho feta bakuli ba nkang placebo "(23).
Ho sebetsa ha gingko biloba ho ntse ho lekoa le maemong a mang a kang attention deficit hyperactive disorder (ADHD) baneng.Thuto e le 'ngoe e fokolang empa e tšepisang ke Sandersleben et al.e tlalehile hore ka mor'a tlatsetso le gingko, "lintlafatso tse kholo li ile tsa fumanoa bakeng sa tlhahlobo ea batsoali ea ho ela hloko ha bana ba bona ... ho tsieleha, ho hloka maikutlo, le kakaretso ea matšoao a matla a matšoao a fokotsehile haholo," le "ntlafatso e kholo mabapi le Boitšoaro ba Prosocial" (24) .Ka lebaka la mefokolo ea thuto, joalo ka ho se be le taolo kapa sampole e kholoanyane, ha ho qeto e tiileng e ka hlahisoang mabapi le katleho ea eona, empa ka tšepo e tla khothaletsa liteko tse qaqileng haholoanyane tsa taolo.
Setlama se seng se sebetsang ka tsela e tšoanang ke Bacopa monniera eo, ho ea ka Levy, phuputso ea morao-rao ea liphoofolo ho Phytotherapy Research e bontšitse "keketseho ea 25% ea phallo ea mali bokong har'a liphoofolo tse nkang 60 mg ea bacopa monniera letsatsi le leng le le leng ha li bapisoa le ho se be le keketseho ea tse fuoeng donepezil. ” (25).
E boetse e boleloa hore e na le thepa ea antioxidant.Ho ea ka Shaheen Majeed, motsamaisi oa mebaraka oa Sabinsa Corp., East Windsor, NJ, bacopa "e thibela lipid peroxidation 'me kahoo e thibela tšenyo ea cortical neurons."Lipid peroxidation e etsahala nakong ea khatello ea oxidative e amanang le khaello ea DHA, eo hape e leng sesupo sa lefu la Alzheimer's.
Mary Rove, ND, mosuoe oa bongaka oa Gaia Herb, Brevard, NC, o boetse o bua ka ho tlatsetsa li-supplement tsa bona tsa Gingko ka litlama tse kang peppermint le rosemary.Ho ea ka eena, peppermint e tšehetsa ho falimeha 'me "lipatlisiso li matlafalitse rosmaranic acid, e leng karolo e sebetsang e nang le thepa ea antioxidant."O phaella ka ho re, "ho na le boitsebiso bo bongata ba morao-rao bo tšehetsang lepetjo le reng 'rosemary bakeng sa khopotso.'
Huperzine A, e boletsoeng pejana bakeng sa ts'ebetso ea eona e le acetylcholinesterase inhibitor, e nkiloe ho setlama sa China Huperzia serrata.Bokhoni ba eona ba ho thibela ho senyeha ha acetylcholine bo tšoana le ba lithethefatsi tse amohetsoeng ke FDA ho phekola matšoao a lefu la Alzheimer ho kenyelletsa donepezil, galantamine le rivastigmine, e leng cholinesterase inhibitors (11).
Meta-analysis e entsoeng ke Yang et al."Huperzine A e bonahala e na le liphello tse molemo ntlafatsong ea ts'ebetso ea kelello, mosebetsi oa letsatsi le letsatsi le tlhahlobo ea lefats'e ea bongaka ho barupeluoa ba nang le lefu la Alzheimer."Leha ho le joalo, ba lemositse hore liphuputso li lokela ho hlalosoa ka hloko ka lebaka la boleng bo bobe ba mekhoa ea liteko tse kenyellelitsoeng, mme ba kopa liteko tse ling tse matla haholoanyane (11).
Li-antioxidants.Bongata ba li-supplement tseo ho buisanoeng ka tsona li na le matla a antioxidant, a thusang ho li etsa hore li sebetse khahlano le mathata a kelello, ao hangata khatello ea oxidative e tlatsetsang ho ona.Ho ea ka Meyers, “Hoo e ka bang maloetseng ’ohle a bokong, ho ruruha ke ntho ea bohlokoa—ho fetola tsela eo lisele li sebelisanang ka eona.”Ke ka lebaka leo ho bileng le keketseho e joalo ea botumo le lipatlisiso ka curcumin, e leng motsoako o fumanoang ho tloha turmeric, o bontšitsoeng ho fokotsa tšenyo ea ho ruruha le ea oxidative bokong le ho tšehetsa ho thunngoa ho nepahetseng ha li-neurone, ho bolela Meyers.
Tabeng ea maemo a kang Alzheimer's, curcumin e ka 'na ea e-ba le monyetla oa ho sitisa ho bokellana ha beta-amyloid.Phuputso e 'ngoe e entsoeng ke Zhang et al., E ileng ea leka curcumin ka litloaelo tsa lisele le mouse primary cortical neurons, e fumane hore setlama se fokolitse maemo a beta-amyloid ka ho liehisa kholo ea amyloid-beta precursor protein (APP).E fokolitse khōlo ea APP ka ho eketsa botsitso ba APP e sa ntseng e hōla ka nako e le 'ngoe le ho fokotsa botsitso ba APP e hōlileng tsebong (26).
Ho hlokahala lipatlisiso tse eketsehileng ho utloisisa ka botlalo hore na curcumin e ka ba le liphello life mabapi le ho tseba le hore na e ka ntlafatsa bokooa ba kelello joang.Hajoale, McCusker Alzheimer's Research Foundation e tšehetsa lipatlisiso tse etsoang Univesithing ea Edith Cowan e Perth, Australia, ho leka ho sebetsa ha curcumin ho bakuli ba nang le bokooa bo fokolang ba kelello.Boithuto ba likhoeli tse 12 bo tla hlahloba hore na setlama se tla boloka tšebetso ea kelello ea bakuli.
Antioxidant e 'ngoe e matla e tšehetsang ts'ebetso ea kelello ke Pycnogenol (e ajoang ke Horphag Research).Ntle le ho ba le matla a mangata khahlanong le tšenyo ea oxidative, setlama, se nkiloeng ho French maritime pine bark, se boetse se bontšitsoe ho ntlafatsa phallo ea mali, ho kenyelletsa le microcirculation bokong hammoho le ho eketsa tlhahiso ea nitric oxide, e sebetsang joaloka neurotransmitter. , mohlomong e tlatsetsa mohopolong le bokhoning ba ho ithuta (25).Phuputsong e 'ngoe ea libeke tse robeli, bafuputsi ba ile ba fa liithuti tse 53 ho tloha ho lilemo tse 18 ho isa ho tse 27 Pycnogenol le ho lekola tšebetso ea bona litekong tsa sebele.Liphello li bontšitse hore sehlopha sa liteko se hlōlehile liteko tse fokolang ho feta taolo (tse supileng vs. robong) 'me li entse 7.6% ho feta taolo (27).WF
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E hatisitsoe ho WholeFoods Magazine Pherekhong 2016
WholeFoods Magazine ke sesebelisoa sa hau sa mantlha bakeng sa lingoloa tsa hajoale tsa bophelo bo botle le phepo e nepahetseng, ho kenyeletsoa mokhoa oa bophelo oa mahala oa gluten le litaba tsa tlatsetso ea lijo.
Sepheo sa lingoliloeng tsa rona tsa bophelo bo botle le phepo e nepahetseng ke ho tsebisa barekisi le barekisi ba lihlahisoa tsa tlhaho ka litaba tsa morao-rao tsa lihlahisoa tsa tlhaho le litaba tsa tlatsetso ea lijo, e le hore ba ka sebelisa menyetla e mecha le ho ntlafatsa likhoebo tsa bona.Makasine ea rona e fana ka leseli la bohlokoa mabapi le mefuta ea lihlahisoa tse ncha le tse ntseng li hlaha tsa indasteri, hammoho le mahlale a mantlha a tlatselletsang lijong.
Nako ea poso: Jun-20-2019