Pyrroloquinoline Quinone disodium Munyu (PQQ)

Utano hwedu hunokanganiswa nezvinhu zvakawanda.Vatengi vanogona kusakurumidza kubatanidza hutano hwekuziva nekugara kwavo kwese, asi hutano hwekuziva, hwemuviri uye kunyangwe hwepfungwa hwakabatanidzwa zvakanyanya.Izvi zvinoratidzwa nenzira yekuti kushomeka kwekudya kwakasiyana-siyana kunogona kukonzera kuderera mukuziva basa (semuenzaniso, B12 uye magnesium).

Zvinoonekwawo sezvatinochembera.Kukura kwatichaita, muviri unokwanisa kunwa zvokudya zvishomanana zvinovaka muviri, izvo zvingaguma nokushomeka.Zviri nyore kubvisa kukanganwa uye kusava nehanya sezviratidzo zvezera, izvo zvavari, asi ivowo zviratidzo zvehutano hwemiviri yedu semugumisiro wekukwegura.Kuwedzera, nekugadzira kushomeka mune zvinovaka muviri, kunogonawo kuvandudza kugona kwekuziva.Heano zvimwe zvinovaka muviri zvine chekuita nehutano hwekuziva.

Chikamu chimwe muzvitatu cheuropi chinoumbwa ne polyunsaturated fatty acids (PUFA), inoverengera 15–30% yehuropi hwakaoma huremu, ine docosahexaenoic acid (DHA) ichiita chikamu chimwe muzvitatu cheiyo (1).

DHA is omega-3 fatty acid inoita basa rakakosha muuropi, ichitarisa muzvikamu zvehuropi zvinoda mwero wepamusoro wekuita kwemagetsi, kusanganisira ma synaptosomes apo magumo etsinga anosangana nekutaurirana, mitochondria, iyo inoburitsa simba rekushandisa. masero etsinga, uye cerebral cortex, inova chikamu chekunze cheuropi (2).Zvakanyatsosimbiswa kuti DHA chinhu chakakosha pakukura kweuropi hwemucheche uye zvakakosha muhupenyu hwese kuchengetedza hutano hwakanaka hwekuziva.Kukosha kweDHA patinenge takura kunova pachena kana tichitarisa kune avo vanobatwa nekuderera kwezera, sechirwere cheAlzheimer (chimiro chedementia chinokonzera kufambira mberi kwendangariro, kurangarira uye kuderera kwehunhu).

Maererano nekuongorora kwakaitwa naThomas et al., "Muvarwere vakaonekwa vane chirwere cheAlzheimer, zvakanyanya kuderera mazinga eDHA akaonekwa muplasma yeropa uye muuropi.Izvi hazvingove zvichikonzerwa nekudzikira kwekudya kweomega-3 fatty acids, asi zvinogona zvakare kukonzerwa nekuwedzera oxidation yePUFAs "(3).

Muvarwere veAlzheimer, kuderera kwekuziva kunofungidzirwa kunokonzerwa neprotein beta-amyloid, ine chepfu kumasero etsinga.Kana mazinga epuroteni iyi akawandisa, anoparadza maturakiti makuru emasero europi, achisiya maamyloid plaques ane chokuita nechirwere (2).

Zvidzidzo zvakasiyana-siyana zvakaratidza kuti DHA inogona kuva neuroprotective effect nekuderedza beta-amyloid toxicity uye nekupa anti-inflammatory effect iyo inogona kuderedza amyloid plaque-yakakonzera oxidative stress uye kuderedza mazinga emapuroteni ane oxidized ne 57% (2).Nepo kushomeka kweDHA muvarwere veAlzheimer kungave nemhedzisiro yekuti kuwedzera kungavabatsire sei, zvinofanirwa kucherechedzwa kuti ma supplements haagone kurapa izvi kana chero chirwere uye zvidzidzo zvine chekuita nemusoro uyu zvakave nemhedzisiro yakasanganiswa.

Zvekuwedzera hazvisi mushonga, uye chokwadi ndechekuti varwere veAlzheimer vakura muzera vanozobatsirwa zvishoma kubva kuDHA kana zvimwe zvinovaka muviri zverutsigiro rwekuziva nekuti panguva yavanozoonekwa, kukuvara kwemuviri kwakatoitwa kuuropi.

Zvakangodaro, vamwe vaongorori vari kuongorora kana DHA yekuwedzera inogona kunonoka kufambira mberi kwekuderera kwekuziva.Itay Shafat Ph.D., sainzi mukuru wechikamu chekudya kunovaka muviri paEnzymotec, Ltd., ane hofisi yeUS muMorristown, NJ, anotaura ongororo yakaitwa naYouko-Mauro et al.iyo yakawana, "Kuwedzerwa kwe900 mg / zuva DHA kwemavhiki e24, kune zvidzidzo zvezera> 55 nekuenzanisa kuderera kwekuziva, kwakavandudza chiyeuchidzo chavo uye unyanzvi hwekudzidza" (4).

Kunyange zvazvo vamwe vatengi vangave vasingafungi nezvehutano hwepfungwa kusvikira matambudziko amuka, chinhu chinokosha kune vatengesi kuvayeuchidza nezvekukosha kweDHA yehuropi muupenyu hwose.Muchokwadi, DHA inogona kutsigira hutano hwekuziva kwevadiki vechidiki vane hutano uye vasina zvinoonekwa zvinoshomeka.Muedzo uchangobva kurongeka wakadzorwa naStonehouse et al., vachidzidza 176 vakuru vane hutano vane makore gumi nemasere kusvika makumi mana nemashanu, vakawana, "DHA yekuwedzera yakavandudza zvakanyanya kuita nguva yekurangarira episodic, nepo kurongeka kwekuyeuka episodic kwakagadziridzwa muvakadzi, uye nguva yekuita ndangariro dzinoshanda dzakavandudzwa muvarume” (5).Kuvandudzika uku paudiki kunogona kushandura kuita muviri nepfungwa dzakagadzirirwa zviri nani kumatambudziko ezera rekukura.

Alpha-linolenic acid (ALA) ndeye omega-3, inowanzo kucheneswa kubva muzvirimwa zvakaita sechia uye flaxseed seimwe nzira yemafuta emugungwa.ALA inofanotungamira kuDHA, asi kutendeuka kwakawanda-nhanho kubva kuALA kuenda kuDHA hakuna kukwana muvanhu vazhinji, nokudaro zvichiita kuti DHA yekudya ive yakakosha parutsigiro rwekuziva.ALA inoita, zvisinei, ine mamwe mabasa akakosha pachayo.Herb Joiner-Bey, chipangamazano wesainzi yezvekurapa weBarlean's, Ferndale, WA, anoti ALA zvakare, "inoshandiswa nemasero europi kugadzira mahormone emuno, anosanganisira 'neuroprotectins,' anokosha pakushanda kweuropi."Anotaura kuti neuroprotectins inowanikwawo yakaderera muvarwere veAlzheimer uye mukuedzwa kwerabhoritari, ALA yakaonekwa yakakosha mukukura kwehuropi.

Zvinhu zvekufunga kana uchitora DHA zvekuwedzera ndeye dosage uye bioavailability.Vanhu vazhinji havawani DHA yakakwana mukudya kwavo uye vangabatsirika nekutora yakanyanya kunyura kana madosi epamusoro.Kukosha kwedosi kwakaburitswa pachena muongororo yemakore mashanu naChew et al.iyo haina kuwana misiyano yakakosha mukuziva basa panguva ye omega-3 yekuwedzera mune vakwegura zvidzidzo (kureva zera: 72) ine zera-yakabatana macular degeneration.Vanamazvikokota vazhinji vezvekudya vakakahadzika nezvekugadzirwa kwechidzidzo.Semuenzaniso, Jay Levy, director wezvekutengesa kuWakunaga weAmerica Co., Ltd., Mission Viejo, CA, akati, "Chikamu cheDHA chaingova 350 mg apo meta-ongororo ichangoburwa yakawana kuti zuva nezuva DHA dosi pamusoro pe580 mg yaidiwa inopa mabhenefiti ekuita kwekuziva" (6).

Douglas Bibus, Ph.D., nhengo yedare rezano resainzi yeCoromega, Vista, CA, akataura chinyorwa cheGlobal Organisation for EPA neDHA Omega-3s (GOED) chine musoro unoti “Omega-3s and Cognition: Dosage Matters.”Boka rakawana, mushure me "kuongorora 20 cognitive-based zvidzidzo zvakaitwa mukati memakore gumi apfuura, zvidzidzo chete zvinopa 700 mg yeDHA kana kupfuura pazuva zvakashuma zvibereko zvakanaka" (7).

Mamwe mafomu ekutumira anogona kuita kuti mafuta emugungwa awedzere kunyura.Semuyenzaniso, Andrew Aussie, mutevedzeri wemutungamiri mukuru uye mukuru anoshanda kuCoromega, anoti kambani yake inoshanda ne, "emulsified omega-3 supplements inopa 300% kunyudzwa kuri nani."Maererano nekudzidza kwaRaatz et al.iyo Aussie inotaura, lipid emulsification mudumbu inhanho inokosha mukudya kwemafuta "kuburikidza nechizvarwa che lipid-water interface inokosha pakubatana pakati pemvura-soluble lipases uye insoluble lipids" (8).Nokudaro, nekuisa emulsifying mafuta ehove, iyi nzira inodarika, ichiwedzera kunwa kwayo (8).

Chimwe chinhu chinokanganisa bioavailability ndeye molecular fomu ye omega-3.Chris Oswald, DC, CNS, nhengo yedare rekupa mazano kuNordic Naturals, Watsonville, CA, anotenda kuti triglyceride fomu ye omega-3s inonyanya kushanda pakusimudza mazinga eropa kupfuura zvinyorwa zvekugadzira.Kana ichienzaniswa neyakagadzirwa ethyl ester-yakasungwa mamorekuru, iyo yakasikwa triglyceride fomu haina kurwisa enzymatic digestion, zvichiita kuti isvike 300% inonyura (2).Nekuda kwechimiro chayo chemolecular yeatatu fatty acids akasungirirwa kumusana weglycerol, kana mafuta ehove akagayiwa, lipid yemukati inoshandurwa kuita imwe-strand fatty acids.Mushure mekunyudzwa kuburikidza nemasero epithelial, anodzoserwa zvakare kuita triglycerides.Izvi zvinogoneka neiyo inowanikwa glycerol musana, iyo ethyl ester yaisazove nayo (2).

Mamwe makambani anotenda phospholipid-yakasungwa omega-3s inovandudza kunyura.Cheryl Meyers, mukuru wezvedzidzo nesainzi paEuroPharma, Inc., Greenbay, WI, anoti chimiro ichi “hachingoite senzira yekufambisa yeomega-3s, asi chinopa tsigiro yakasimba yehuropi pachayo.Myers anotsanangura chimwe chekuwedzera kubva kukambani yake inopa phospholipid-yakasungwa omega-3s yakatorwa kubva kumisoro yesalmon (Vectomega).Iyo yekuwedzera inewo peptides yaanotenda kuti "inogona kuchengetedza tsinga dzeropa muuropi nekurwisa kukuvara kweoxidative."

Nezvikonzero zvakafanana, mamwe makambani anosarudza kugadzira nemafuta ekrill, imwe sosi yephospholipid-yakasungwa omega-3s inopa yakanaka bioavailability nekuda kwekunyungudika kwemvura.Lena Burri, director wezvesainzi kunyora kuAker Biomarine Antarctic AS, Oslo, Norway, inopa imwe tsananguro yekuti sei iyi fomu yeDHA yakakosha: imwe "DHA transporter (Mfsd2a, mufambisi mukuru wemhuri domain ine 2a) ... inobvuma DHA chete kana inosungirirwa kune phospholipids-kuva chaiyo kune lysoPC" (9).

Imwe yakasarudzika, yakapetwa kaviri-mapofu, yakafanana-boka-boka kuenzanisa mhedzisiro yakayera mhedzisiro yekrill mafuta, sardine mafuta (triglyceride fomu) uye placebo pakushanda ndangariro uye kuverenga mabasa mu45 varume vakuru mazera kubva 61-72 kwemavhiki gumi nemaviri.Nekuyera shanduko yeoxyhemoglobin concentrations panguva yemabasa, mhedzisiro yakaratidza shanduko huru mukusungwa mune imwe chiteshi mushure memavhiki gumi nemaviri kupfuura placebo, zvichiratidza kuti kuwedzeredza kwenguva refu kwese krill uye sardine mafuta "kunokurudzira kushanda kwendangariro basa nekuita dorsolateral prefrontal cortex kune vakwegura. vanhu, uye nokudaro kudzivirira kudzikira mukuita kwekuziva”(10).

Zvisinei, maererano nemabasa ekuverenga, mafuta ekrill "yakaratidza kuchinja kwakanyanya muhuwandu hweoxyhemoglobin munzvimbo yekuruboshwe yakatarisana," zvichienzaniswa ne placebo uye sardine mafuta, iyo isina kuratidza chero maitiro ekugadzirisa panguva yekuverenga mabasa (10).

Kunze kwekubatsira mukutora omega-3s, phospholipids inoita basa rakakosha muhutano hwekuziva ivo pachavo.Maererano naBurri, phospholipids inoumba inenge 60% yehuropi nehuremu, kunyanya kupfumiswa mumadendrites uye synapses.Pamusoro peizvi, anoti mu vitro, kukura kwetsinga kunogadzira kuwedzera kudiwa kwephospholipids uye nerve yekukura chinhu inosimudzira phospholipid chizvarwa.Kuwedzera ne phospholipids kunoshandiswa zvakanyanya uye kunoshanda mukubatsira kugona kwekuziva nekuti chimiro chayo chakafanana neicho chiri mutsinga membranes.

Maviri akajairika phospholipids phosphatidylserine (PS) uye phosphatidylcholine (PC).Shafat anoti PS ine zvichemo zvehutano zvakatenderwa neUS Food and Drug Administration (FDA).Zvichemo zvinosanganisira: "Kushandisa PS kunogona kuderedza njodzi yedementia kune vakwegura," "Kushandisa PS kunogona kuderedza njodzi yekusashanda zvakanaka kwevakwegura," uye vane ruzivo, "Kunyanya kushoma uye kwekutanga tsvagiridzo yesainzi inoratidza kuti PS inogona kuderedza njodzi. ye dementia / kuderedza njodzi yekusagadzikana kwekuziva kune vakwegura.FDA inogumisa kuti kune humbowo hushoma hwesainzi hunotsigira izvi. "

Shafat anotsanangura kuti pachayo, PS "inoshanda nechekare pachiyero che100 mg / zuva," chiyero chidiki pane zvimwe zvekuziva-rutsigiro zvinongedzo.

Nezvebasa rayo, Chase Hagerman, brand director kuChemiNutra, White Bear Lake, MN, anoti PS "inobatsira mapuroteni anodzora mabasa emu membrane akabatanidzwa mukufambiswa kwemamolecular meseji kubva kune sero kuenda kune sero, anobatsira zvinovaka muviri kupinda mumasero, uye zvinobatsira. marara anokuvadza ane chekuita nekushushikana kuti abude musero."

PC, kune rumwe rutivi, yakadai seyakaumbwa kubva ku-alpha-glyceryl phosphoryl choline (A-GPC), Hagerman anoti, "inotamira kune synaptic nerve endings inowanikwa mukati mese central central nervous system, uye inowedzera iyo synthesis uye kusunungurwa kwe acetylcholine (AC)," inova neurotransmitter yakakosha "iripo muhuropi nemunyama matishu," ichiita basa rakakosha mu "chaizvoizvo zvese zvekuziva basa nepo mumhasuru inobatanidzwa zvakanyanya mukubatana kwemhasuru."

Zvinhu zvakasiyana-siyana zvinoshanda kune izvi.Dallas Clouatre, Ph.D., R&D consultant kuJarrow Formulas, Inc., Los Angeles, CA, anovarondedzera se "mhuri yakawedzerwa yeimwe substrate," iyo inosanganisira uridine, choline, CDP-choline (Citocoline) uye PC se. chikamu chekutenderera kwehuropi dzimwe nguva inonzi Kennedy Cycle.Zvese izvi zvinhu zvinoita basa mukugadzira PC muuropi uye nekudaro synthesizing AC.

Kugadzirwa kweAC chimwezve chinhu chinodzikira sezvatinokura.Zvisinei, kazhinji, nokuti neurons haigoni kubereka choline yavo uye inofanira kuigamuchira kubva muropa, kudya kusina choline kunogadzira kusakwana kwe AC (2).Kushaikwa kwecholine iripo kunobata basa mukukura kwezvirwere zvakaita seAlzheimer's uye zvine chekuita nezera rekuziva kuderera.Basa remuongorori Richard Wurtman, MD, anobva kuMassachusetts Institute of Technology rakurudzira kuti nekuda kwekushaikwa kwecholine, uropi hunogona kunyatso bvisa PC kubva kune yayo neural membrane kugadzira AC (2).

Neil E. Levin, CCN, DANLA, maneja wezvidzidzo zvinovaka muviri paNOW Foods, Bloomingdale, IL inotsanangura kuumbwa "inotsigira kusvinura kwepfungwa uye kudzidza nekusimudzira kugadzirwa kwakakodzera kweAC uye basa," nekubatanidza A-GPC, "iyo bioavailable fomu yecholine. ,” neHuperzine A kuchengetedza AC mazinga (RememBRAIN kubva NOW Foods).Huperzine A inochengetedza AC kuburikidza nekushanda sekusarudza inhibitor yeacetylcholinesterase, iyo enzyme inokonzera kuparara kwe AC (11).

Sekureva kwaLevy, citicoline ndechimwe chezvinhu zvitsva zvekutsigira cognition, yakanangana neiyo lobe yepamberi, inova nzvimbo inokonzeresa kugadzirisa matambudziko, kutarisisa uye kuisa pfungwa.Anotaura kuti kuwedzera ne citicoline muvakuru vakuru kwakaratidza "kuvandudza ndangariro yemashoko, ndangariro nekuziva, kutarisisa nguva, kuyerera kweropa kuuropi uye bioelectrical chiitiko."Anotaura zvidzidzo zvakawanda zvakaratidza migumisiro yakanaka, kusanganisira muedzo wakapetwa kaviri-bofu, randomized, placebo-controlled controlled yevarwere veAlzheimer's 30 iyo yakaratidza kuvandudzwa kwehutano hwepfungwa kana ichienzaniswa ne placebo mushure mekutora citicoline zuva rega rega, kunyanya pakati pevaya vane dementia (12).

Elyse Lovett, maneja wezvekushambadzira kuKyowa USA, Inc., New York, NY, anoti kambani yake ine "itiko chete yakadzidzwa nekiriniki ye citicoline muvanhu vakuru vane hutano nevechiri kuyaruka," uye kuti "ndiyo chete nzira ye citicoline ne GRAS [kazhinji. inozivikanwa seyakachengeteka] chinzvimbo muUnited States” (Cognizin).

Chimwe chekuwedzera chine hukama, sekureva kwaDan Lifton, purezidhendi weMaypro's Proprietary Branded Ingredients Group, Purchase, NY, iri INM-176 yakatorwa kubva kumudzi Angelica gigas Nakai, iyo yakaratidzawo kutsigira hutano hwekuziva nekuwedzera huropi huwandu hweAC.

Kushaikwa kwevhitamini kunowanzo kuzviratidza kuburikidza nekuderera kwekuziva basa.Kushaikwa kweVitamin B12, semuenzaniso, kunogona kusanganisira zviratidzo zvakadai sekuvhiringidzika, kurasikirwa nekuyeuka, kushanduka kwehunhu, paranoia, kuora mwoyo uye mamwe maitiro akafanana nedementia.Kwete izvozvo chete, asi 15% yevakuru uye yakawanda se40% yevanhu vane zviratidzo pamusoro pemakore makumi matanhatu ezera vane yakaderera kana yemuganhu B12 mazinga (13).

Maererano naMohajeri et al., B12 inobata basa rinokosha pakushandura homocysteine ​​(Hcy) muamino acid methionine, asi mamwe mavhithamini eB folate (B9) uye B6 anodiwa macofactors kuti metabolism iite, pasina iyo, Hcy inounganidza.Hcy is amino acid inogadzirwa mumuviri kubva mukudya methionine uye yakakosha kune yakajairika cellular basa, asi yakanyanya kuwanda kwayo inodzikisira kushanda kwayo (14)."Mwero wepamusoro weropa wehomocysteine ​​​​unoratidzwa kuti unokanganisa ndangariro uye zvimwe zvinoverengeka zvebasa rekuziva," anodaro Michael Mooney, mutungamiriri wesainzi uye dzidzo paSuperNutrition, Oakland, CA.

Mohajeri et al.inosimbisa ichi chirevo: “Kuoma kwekusaziva zvakanaka kwave kwakabatana nekuwedzera kwehuwandu hweplasma Hcy.Zvakare, njodzi yakakura kwazvo yechirwere cheAlzheimer yakataurwa apo ese ari maviri folate uye B12 mazinga aive akaderera ”(15).

Niacin imwe B vhitamini inotsigira ndangariro uye cognitive basa.Maererano naMooney, niacin, iyo inonyanya kushanda yevhitamini B3, inowanzorongedzerwa navanachiremba pa1,000 mg kana kupfuura pazuva kuti vatsigire yakajairika cholesterol mazinga, asi chidzidzo chinodzorwa ne placebo chakawana kuti kudya kunovaka muviri kwe425 mg pazuva kwakavandudza chiyeuchidzo. bvunzo zvibodzwa nekuwanda se40% pamwe nekuvandudza sensory registry nekuwanda se40%.Pamasimba akakwirira, niacin inoratidzwawo kuvandudza cerebral blood flow, "iyo inowedzera kupararira kwezvokudya uye oksijeni muuropi," anowedzera (16).

Kuwedzera kune niacin, Mooney anotsanangura niacinamide, inova imwe mhando yevhitamini B3.Pa3,000 mg/zuva, niacinamide iri kudzidzwa neUC Irvine semushonga ungangoita weAlzheimer's uye kurasikirwa nekurangarira kwakabatana nawo mushure memhedzisiro yakanaka mukudzidza mbeva.Mafomu ese ari maviri, anotsanangura, anoshandura mumuviri kuita NAD +, molekuru yakaratidzwa kudzosera kuchembera mumitochondria, iyo yakakosha zvakanyanya cellular simba inogadzira."Izvi zvinogona kubatsira zvakanyanya mukusimudzira ndangariro kwevhitamini B3 uye zvimwe zvinopesana nekuchembera," anodaro.

Imwe yekuwedzera yekukurudzira vatengi ndeye PQQ.Clouatre anoti rinorangarirwa nevamwe sevhitamini itsva chete yakawanikwa mumakumi emakore anoverengeka apfuura, zvichiratidza migumisiro yakanaka munzvimbo dzakadai seneuroprotection."PQQ inodzvanyirira chizvarwa chakawandisa chehuwandu hwema radicals, kusanganisira iyo yakanyanya kukuvadza peroxynitrite radical," anodaro, uye muPQQ yakaratidza mhedzisiro mukudzidza nekuyeuka mune zvese mhuka uye zvidzidzo zvevanhu.Imwe ongororo yekiriniki yakawana kuti musanganiswa we20 mg wePQQ uye CoQ10 wakapa mabhenefiti akakura muzvidzidzo zvevanhu mundangariro, kutarisisa uye cognition (17).

Lifton anoti senge niacin, PQQ uye CoQ10 inotsigira mitochondrial basa.Anotaura kuti CoQ10 inoita izvi nekuchengetedza "mitochondria kunyanya kubva mukukuvadzwa nekuda kwekurwiswa kwemahara," pamwe nekuwedzera "kugadzirwa kwesimba remagetsi, izvo zvinogona kuita kuti simba rakawanda riwanikwe kune maitiro ekuziva."Izvi zvakakosha nekuti "kutsvagisa kutsva kunofadza kunoratidza kuti chimwe chezvikonzero zvinokonzeresa zvikanganiso zvendangariro zvine chekuita nekuchembera kukuvadzwa kwemitochondria yedu," anodaro Lifton.

Magnesium iminerari yakakosha yekuchengetedza basa rakanaka rekuziva, kana kune iyo nyaya, kushanda kwemuviri sese.Sekureva kwaCarolyn Dean, MD, ND, nhengo yedare rezano rezvekurapa reNutritional Magnesium Association, "Magnesium chete inodiwa mu700-800 akasiyana enzyme masisitimu" uye "ATP (adenosine triphosphate) kugadzirwa muKrebs kutenderera kunoenderana nemagnesium kune matanhatu. zvematanho ayo masere.

Pamberi pekuziva, Dean anoti magnesium inovhara neuro-kuzvimba kunokonzerwa nekuiswa kwecalcium uye mamwe masimbi anorema mumasero europi pamwe nekuchengetedza nzira dzeion uye kuvhara simbi dzinorema kupinda.Anotsanangura kuti kana magnesium yakadzikira, calcium inopinda ichimhanya ichikonzera kufa kwesero.Levin anowedzera, "Kutsvakurudza kwemazuva ano kwakaratidza kuti zvakakoshawo kune hutano hwakanaka hwehuropi uye hutano hwekuziva nekuchengetedza hutsika uye kugadzikana kweuronal synapses."

Mubhuku rake rinonzi Magnesium Miracle, Dean anotsanangura kuti kuperevedza kwemagnesium chete kunogona kuparira zviratidzo zvedementia.Izvi ndezvechokwadi kunyanya patinenge tichikura, sezvo kugona kwemuviri kutora magnesium kubva mukudya kwedu kunodzikira uye zvakare kunogona kudziviswa nemishonga inowanikwa muvanhu vakura (18).Saka, mazinga e magnesium muropa anogona kuderera nekuti muviri hauna kugona kutora mineral, kudya kwakashata uye mishonga, kugadzira yakawandisa yecalcium uye glutamate (kunyanya kana kudya chikafu chakakwira muMSG), zvese zviri zviviri zvine basa rekuita. mukusingaperi neural degeneration uye kukura kwekuora mwoyo (19).

Nepo zvinovaka muviri zvakakosha pakuchengetedza hutano hwekuziva basa, herbal aids inogonawo kupa rumwe rutsigiro mune akasiyana siyana.Zera-nechekuita nekuziva kuderera uye dementia inogona kugadzirwa nenzira dzakasiyana-siyana, nekuderedzwa kwecerebral kuyerera kweropa iri imwe yenzira dzakasiyana.Mishonga yakawanda inoshanda kutarisana nechinhu ichi.Zvinofanira kuonekwa kuti mishonga inovandudza kutenderera kweropa inogona kuva nengozi kune vatengi vari kutora mishonga inoderedza ropa yakadai sewarfarin.

Basa guru reGingko biloba kuwedzera kuyerera kweropa rehuropi, iro rinoita basa guru mukukura kwedementia ingave yakatanga neAlzheimer's kana cerebrovascular disease.Zvinonzi zvakare kudzoreredza kukanganisa mitochondrial basa rekuvandudza neuronal simba rekupa, kuwedzera choline kukwira muhippocampus, inhibit aggregation uye chepfu yeb-amyloid protein uye ine antioxidant mhedzisiro (20, 21).

Levy inotaura nezvechidzidzo chekuedza kwemavhiki mana muNeuroradiology iyo "yakaratidza kuwedzera kwechina kusvika kune manomwe kubva muzana mukuyerera kweropa pachiyero chepakati che 120 mg pazuva" yegingko (22).Imwe yakasiyana randomized, placebo-inodzorwa, kaviri-mapofu kudzidza kutarisa kushanda uye kuchengetedzwa kwegingko biloba kune varwere vane hunyoro hwekuziva uye neuropsychiatric zviratidzo (NPS) naGavrilova et al., vakawana kuti "panguva ye24-vhiki yekurapa, kuvandudzwa kweNPS uye kugona kwekuziva kwaive kwakakosha uye kwainyanya kutaurwa kune varwere vanotora 240 mg pazuva reG. biloba inobvisa EGb 761 pane varwere vanotora placebo "(23).

Kushanda kwe gingko biloba kuri kutoedzwa pane mamwe mamiriro akadai seattention deficit hyperactive disorder (ADHD) muvana.Imwe shoma asi inovimbisa kudzidza naSandersleben et al.yakashuma kuti mushure mekuwedzera ne gingko, "kuvandudzika kwakakosha kwakawanikwa pakuongorora kwevabereki kwekuteerera kwevana vavo ... kushaya simba, kusagadzikana, uye nhamba yose yechiratidzo chekuoma kwakaderera zvikuru," uye, "kuvandudzwa kwakakosha maererano neProsocial Behavior" (24) .Nekuda kwekugumira kwechidzidzo, sekusava nekutonga kana sampuli yakakura, hapana mhedziso yakasimba inogona kukweverwa pakuita kwayo, asi netarisiro ichakurudzira yakadzama yakasarudzika, kutonga miedzo.

Imwe mishonga inoshanda zvakafanana ndeyeBacopa monniera iyo, maererano naLevy, chidzidzo chemhuka chichangobva kuitika muPhytotherapy Research chakaratidza "25% kuwedzera kwekuyerera kweropa kuuropi pakati pemhuka dzinotora 60 mg ye bacopa monniera zuva nezuva zvichienzaniswa nekusawedzera kune avo vakapiwa donepezil. ” (25).

Inonziwo ine antioxidant properties.Sekureva kwaShaheen Majeed, director director weSabinsa Corp., East Windsor, NJ, bacopa "inodzivirira lipid peroxidation uye nekudaro inodzivirira kukuvadzwa kwecortical neurons."Lipid peroxidation inoitika panguva yeoxidative kusagadzikana kwakabatana nekushomeka kweDHA, iyo, zvakare, chiratidzo cheAlzheimer's.

Mary Rove, ND, mudzidzisi wezvokurapa paGaia Herb, Brevard, NC, anotaurawo kuwedzera kwavo Gingko kuwedzera nemishonga yakadai se peppermint uye rosemary.Sekureva kwake, peppermint inotsigira kusvinura uye "tsvagiridzo yakasimudzira rosmaranic acid, inoshanda ine antioxidant zvimiro."Anowedzera kudaro, “kune mashoko akawanda emazuva ano anosimbisa sirogani iya yekuti 'rosemary yendangariro.'

Huperzine A, yakambotaurwa nezvekushanda kwayo seacetylcholinesterase inhibitor, inotorwa kubva kuChinese herb Huperzia serrata.Kugona kwayo kudzivirira kuparara kweacetylcholine kwakafanana neiyo yeFDA-yakatenderwa mishonga inotenderwa kurapa zviratidzo zvechirwere cheAlzheimer zvinosanganisira donepezil, galantamine uye rivastigmine, ayo ari cholinesterase inhibitors (11).

Meta-analysis yakaitwa naYang et al.yakagumisa, "Huperzine A inoratidzika kuva nemigumisiro inobatsira pakuvandudza kushanda kwekuziva, mararamiro ezuva nezuva uye kuongororwa kwekliniki yepasi rose kune vatori vechikamu vane chirwere cheAlzheimer."Vakayambira, zvisinei, kuti zvakawanikwa zvinofanirwa kududzirwa zvine hungwaru nekuda kwehurombo hwemaitiro emhando yemiedzo inosanganisirwa, uye yakadana mimwe miedzo yakaoma (11).

Antioxidants.Mazhinji ezvakakurukurwa ekuwedzera ane antioxidant masimba, ayo anobatsira kuti aite kuti ashande kurwisa kukanganisa kwekuziva, izvo zvinokonzeresa oxidative kusagadzikana.Maererano naMeyers, "Munenge zvirwere zvose zviri muuropi, kuzvimba chinhu chinokosha-kunoshandura maitiro ekuti masero anobatana sei."Ndicho chikonzero kwave kune kuwedzera kwakadai mukuzivikanwa uye kutsvakurudza mu curcumin, iyo inhengo inowanikwa kubva kune turmeric, inoratidzwa kuderedza kukuvara kwekuputika uye oxidative muuropi uye kutsigira kupfurwa kwakakodzera kweneurons, anodaro Meyers.

Mumamiriro ezvinhu akadai seAlzheimer's, curcumin inogona kunge iine mukana wekukanganisa kuvakwa kwe beta-amyloid.Imwe ongororo yakaitwa naZhang et al., iyo yakaedza curcumin pamasero tsika uye mbeva yekutanga cortical neurons, yakawana kuti herb yakaderedza beta-amyloid mazinga nekunonotsa kukura kweamyloid-beta precursor protein (APP).Iyo yakadzora kukura kweAPP nekuwedzera panguva imwe chete kugadzikana kweasina kukura APP uye kuderedza kugadzikana kwevakuru APP (26).

Kutsvakurudza kwakawanda kunodiwa kuti unzwisise zvizere mhando yemhedzisiro inogona kuve necurcumin pakuziva uye kuti inogona sei kuvandudza kukanganiswa kwekuziva.Parizvino, McCusker Alzheimer's Research Foundation iri kutsigira tsvakiridzo iri kuitwa paEdith Cowan University muPerth, Australia, kuyedza kushanda kwe curcumin pavarwere vane hurema hwekuziva.Chidzidzo chemwedzi gumi nemiviri chichaongorora kana mushonga wacho uchachengetedza huchenjeri hwemurwere.

Imwe antioxidant ine simba inotsigira cognitive basa iPycnogenol (inoparadzirwa neHorphag Research).Kunze kwekuve simba rakawanda rinopesana nekukuvara kweoxidative, herb, iyo inotorwa kubva kuFrench maritime pine bark, yakaratidzawo kuvandudza kutenderera kweropa, kusanganisira microcirculation muuropi pamwe nekuwedzera kugadzirwa kwenitric oxide, inoshanda seyeurotransmitter. , zvichida zvichibatsira kuyeuka uye kukwanisa kudzidza (25).Mune kumwe kuongorora kwemavhiki masere, vaongorori vakapa vadzidzi makumi mashanu nevatatu kubva pazera re18 kusvika pa27 Pycnogenol uye vakaongorora mashandiro avo pabvunzo chaidzo.Migumisiro yakaratidza kuti boka rekuedza rakakundikana miedzo shoma pane kutonga (zvinomwe vs. mapfumbamwe) uye yakaita 7.6% zviri nani pane kutonga (27).WF

1. Joseph C. Maroon naJeffrey Bost, Mafuta Ehove: The Natural Anti-Inflammatory.Basic Health Publications, Inc. Laguna Beach, California.2006. 2. Michael A. Schmidt, Brian-Building Nutrition: Madyiro Ekudya uye Mafuta Anokanganisa Pfungwa, Muviri, uye Emotional Intelligence, Yechitatu Edition.Frog Books, Ltd. Berkeley, California, 2007. 3. J. Thomas et al., "Omega-3 fatty ccids mukudzivirira kwekutanga kwechirwere chinoputika neurodegenerative: Kutarisa pachirwere cheAlzheimer."Hindawa Publishing Corporation, BioMed Research International, Vhoriyamu 2015, Chinyorwa ID 172801. 4. K. Yurko-Mauro et al., "Batsiro mhedzisiro yedocosahexaenoic acid pakuziva mukuderera kwekuziva kwezera."Alzheimers Dement.6(6): 456-64.2010. 5. W. Stonehouse et al., "DHA yekuwedzera yakavandudza zvese zvekuyeuka uye nguva yekuita muvanhu vechidiki vane hutano: muyedzo wakasarudzika."Ndiri J Clin Nutr.97: 1134-43.2013. 6. EY Chew et al.,” Mhedzisiro yeomega-3 fatty acids, lutein/zeaxanthin, kana zvimwe zvinovaka muviri pakuziva basa: the AREDS2 randomized clinical trial.JAMA.314(8): 791-801.2015. 7. Adam Ismail, "Omega-3s uye cognition: dosage nyaya."http://www.goedomega3.com/index.php/blog/2015/08/omega-3s-and-cognition-dosage-matters.8. Susan K. Raatz et al., "Kuwedzerwa kutorwa kweomega-3 fatty acids kubva kune emulsified kana ichienzaniswa neyakavharirwa mafuta ehove."J Am Diet Assoc.109(6).1076-1081.2009. 9. LN Nguyen et al., "Mfsd2a mutakuri weiyo yakakosha omega-3 fatty acid docosahexaenoic acid."http://www.nature.com/nature/journal/v509/n7501/full/nature13241.html 10. C. Konagai et al., "Migumisiro yemafuta ekrill ane n-3 polyunsaturated fatty acids mune phospholipid fomu pauropi hwevanhu basa: muyedzo unodzorwa zvisina tsarukano mune vakwegura vane hutano vanozvipira. "Clin Interv Kuchembera.8: 1247-1257.2013. 11. Guoyan Yang et al., "Huperzine A yechirwere cheAlzheimer: kuongorora kwakarongeka uye meta-analysis ye randomized clinical trials."PLoS IMWE.8(9).2013. 12. XA.Alvarez et al."Double-blind placebo-controlled controlled study ne citicoline muAPOE genotyped Alzheimer's disease varwere: Migumisiro pakuita kwekuziva, brain bioelectrical activity uye cerebral perfusion."Nzira dzekutsvaga Exp Clin Pharmacol.21(9):633-44.1999. 13. Sally M. Pacholok naJeffrey J. Stuart.Inogona kunge iri B12: Epidemic of Misdiagnosis, Second Edition.Quill Driver Books.Fresno, CA.2011. 14. M. Hasan Mohajeri et al., "Kusakwana kwevhitamini neDHA kune vakwegura: Zvinokonzeresa kuchembera kweuropi uye Alzheimer-type dementia."Nutrition.31:261-75.2015. 15. SM.Loriaux et al."Migumisiro ye nicotinic acid uye xanthinol nicotinate pandangariro dzevanhu mumapoka akasiyana ezera.A double blind study.”Psychopharmacology (Berl).867 (4): 390-5.1985. 16. Steven Schreiber, "Safety Study yeNicotinamide Kurapa Chirwere cheAlzheimer."https://clinicaltrials.gov/ct2/show/NCT00580931?term=nicotinamide+alzheimer%27s&rank=1.17. Koikeda T. et.al, "Pyrroloquinoline quinone disodium munyu yakavandudza kushanda kwehuropi."Kuonana Kwezvokurapa uye Mishonga Mitsva.48(5): 519. 2011. 18. Carolyn Dean, Chishamiso cheMagnesium.Ballantine Books, New York, NY.2007. 19. Dehua Chui et al., "Magnesium muAlzheimer's disease."Magnesium muCentral Nervous System.Yunivhesiti yeAdelaide Press.2011 .Clinical Kupindira muKukwegura.9: 2065-2077.2014 .Curr Psychiatry Rep. 6(8), 456. 2014. 22. A. Mashayekh, et al., "Migumisiro yeGinkgo biloba pahuropi hwekuyerera kweropa yakaongororwa nehuwandu hweMR perfusion imaging: pilot study."Neuroradiology.53(3):185-91.2011. 23. SI Gavrilova, et al., "Kubudirira uye kuchengeteka kweGingko biloba inobvisa EGb 761 mukusaziva zvakanaka kwekuziva nezviratidzo zveurouropsychiatric: chirongwa che randomized, placebo controlled, double-blind, multicenter."Int J Geriatr Psychiatry.29:1087-1095.2014. 24. HU Sandersleben et al., "Gingko biloba inobvisa EGb 761 muvana vane ADHD."Z. Kinder-Jugendpsychiatr.Psychother.42 (5): 337-347.2014. 25. N. Kamkaew, et al., "Bacopa monnieri inowedzera kuyerera kweropa mumakonzo asingaenderane neBP."Phytother Res.27(1):135-8.2013. 26. C. Zhang, et al., "Curcumin inoderedza amyloid-beta peptide mazinga nekudzikisira kukura kweamyloid-beta precursor protein."J Biol Chem.285(37): 28472-28480.2010. 27. Richard A. Passwater, Bhuku reMushandisi kuPynogenol Nature's Most Versatile Supplement.Basic Health Publications, Laguna Beach, CA.2005. 28. R. Lurri, et al., "Pynogenol supplementation inovandudza kugona kwepfungwa, kutarisa uye kushanda kwepfungwa muvadzidzi."J Neurosurge Sci.58(4): 239-48.2014.

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Chinangwa chezvinyorwa zvedu zvehutano nezvekudya ndechekuzivisa vatengesi vezvigadzirwa zvechisikigo uye vatengesi nezve chazvino chigadzirwa chechisikigo uye nhau dzekuwedzera dzezvekudya, kuti vatore mukana wemikana mitsva nekuvandudza mabhizinesi avo.Magazini yedu inopa ruzivo rwakakosha maererano nezvikamu zvezvigadzirwa zveindasitiri zvitsva uye zviri kusimukira, pamwe nesainzi kuseri kwechikafu chekuwedzera.