Pyrroloquinoline Quinone Disodium ntsev (PQQ)

Peb kev noj qab haus huv cuam tshuam los ntawm ntau yam.Cov neeg yuav khoom tsis tuaj yeem koom nrog kev paub txog kev noj qab haus huv tam sim ntawd nrog lawv txoj kev noj qab haus huv tag nrho, tab sis kev txawj ntse, lub cev thiab kev xav txog kev noj qab haus huv tau cuam tshuam ntau heev.Qhov no tau pom nyob rau hauv txoj kev uas ntau yam khoom noj khoom haus tsis txaus tuaj yeem ua rau poob ntawm kev txawj ntse (xws li, B12 thiab magnesium).

Nws kuj tshwm sim thaum peb muaj hnub nyoog.Thaum peb laus lawm, cov khoom noj tsawg dua lub cev tuaj yeem nqus tau los ntawm cov zaub mov, uas yuav ua rau muaj qhov tsis txaus.Nws yog ib qho yooj yim kom tso tseg tsis nco qab thiab tsis muaj kev tsom xam raws li cov tsos mob ntawm lub hnub nyoog, uas lawv yog, tab sis lawv kuj yog cov tsos mob ntawm tag nrho cov mob ntawm peb lub cev raws li kev laus.Supplementation, los ntawm kev ua kom tsis txaus ntawm cov as-ham, tuaj yeem txhim kho kev txawj ntse.Nov yog qee cov khoom noj tshwj xeeb cuam tshuam nrog kev paub txog kev noj qab haus huv.

Ib feem peb ntawm lub hlwb yog tsim los ntawm polyunsaturated fatty acids (PUFA), suav txog 15-30% ntawm lub hlwb qhuav qhov hnyav, nrog docosahexaenoic acid (DHA) ua txog ib feem peb ntawm qhov ntawd (1).

DHA yog ib qho omega-3 fatty acid uas ua lub luag haujlwm tseem ceeb hauv lub hlwb, tsom mus rau qhov chaw ntawm lub hlwb uas xav tau qhov siab tshaj plaws ntawm kev ua haujlwm hluav taws xob, suav nrog cov synaptosomes qhov twg cov paj hlwb sib ntsib thiab sib txuas lus nrog ib leeg, mitochondria, uas tsim lub zog rau paj hlwb, thiab cerebral cortex, uas yog txheej txheej ntawm lub hlwb (2).Nws tau tsim tau zoo tias DHA yog ib qho tseem ceeb rau kev loj hlob ntawm cov me nyuam mos thiab me nyuam lub hlwb thiab nws yog ib qho tseem ceeb nyob rau hauv lub neej rau kev tswj kom zoo kev txawj ntse.Qhov tseem ceeb ntawm DHA thaum peb muaj hnub nyoog dhau los ua pov thawj thaum saib cov cuam tshuam los ntawm lub hnub nyoog poob qis, xws li Alzheimer's kab mob (ib hom kev dementia uas ua rau muaj kev nco, kev txawj ntse thiab kev coj cwj pwm poob).

Raws li kev tshuaj xyuas los ntawm Thomas et al., "Nyob rau hauv cov neeg mob kuaj pom tias muaj tus kab mob Alzheimer's, txo qis DHA qib tau pom hauv cov ntshav plasma thiab hlwb.Qhov no tsis yog tsuas yog vim kev noj zaub mov tsawg ntawm omega-3 fatty acids, tab sis nws kuj tuaj yeem raug ntaus nqi rau oxidation ntawm PUFAs "(3).

Hauv cov neeg mob Alzheimer, kev paub txog kev poob qis yog xav tias yog los ntawm cov protein beta-amyloid, uas yog tshuaj lom rau cov paj hlwb.Thaum cov qib ntawm cov protein ntau dhau lawm, lawv rhuav tshem cov kab mob loj ntawm lub hlwb, tawm hauv qab cov amyloid plaques uas cuam tshuam nrog tus kab mob (2).

Ntau yam kev tshawb fawb tau pom tias DHA tuaj yeem muaj cov txiaj ntsig zoo los ntawm kev txo cov beta-amyloid toxicity thiab los ntawm kev muab cov tshuaj tiv thaiv kab mob uas tuaj yeem txo cov amyloid plaque-ua rau oxidative kev nyuaj siab thiab txo cov qib ntawm oxidized proteins los ntawm 57% (2).Thaum DHA tsis txaus hauv Alzheimer's cov neeg mob tej zaum yuav muaj qee qhov cuam tshuam rau qhov kev pab ntxiv tuaj yeem pab tau lawv li cas, nws yuav tsum raug sau tseg tias cov tshuaj tsis tuaj yeem kho qhov no lossis ib qho kab mob thiab cov kev tshawb fawb hais txog cov ntsiab lus tau sib xyaw ua ke.

Cov tshuaj ntxiv tsis yog tshuaj, thiab qhov tseeb yog Alzheimer cov neeg mob siab rau hnub nyoog yuav tau txais txiaj ntsig tsawg tshaj plaws los ntawm DHA lossis lwm yam nutraceuticals rau kev paub txog kev txawj ntse vim hais tias los ntawm lub sij hawm lawv kuaj pom, lub cev puas tsuaj twb tau ua rau lub hlwb.

Txawm li cas los xij, qee cov kws tshawb fawb tab tom tshawb xyuas seb DHA supplementation tuaj yeem ua rau kev loj hlob ntawm kev txawj ntse poob.Itay Shafat Ph.D., tus kws tshawb fawb laus rau kev faib khoom noj khoom haus ntawm Enzymotec, Ltd., nrog US chaw ua haujlwm hauv Morristown, NJ, hais txog kev tshawb fawb los ntawm Yourko-Mauro li al.uas pom, "Kev ntxiv ntawm 900 mg / hnub DHA rau 24 lub lis piam, rau cov neeg muaj hnub nyoog> 55 xyoo nrog kev paub tsis meej qis, txhim kho lawv cov kev nco thiab kev kawm" (4).

Txawm hais tias qee tus neeg siv khoom yuav tsis xav txog kev paub txog kev noj qab haus huv kom txog thaum muaj teeb meem, nws yog qhov tseem ceeb rau cov khw muag khoom kom nco ntsoov lawv txog qhov tseem ceeb ntawm DHA rau lub hlwb thoob plaws lub neej.Qhov tseeb, DHA tuaj yeem pab txhawb kev paub txog kev noj qab haus huv ntawm cov tub ntxhais hluas uas muaj kev noj qab haus huv thiab tsis muaj cov zaub mov tsis txaus.Tsis ntev los no randomized tswj kev sim los ntawm Stonehouse li al., kawm 176 noj qab nyob zoo cov neeg laus hnub nyoog 18 txog 45, pom, "DHA supplementation ho txhim kho lub sij hawm cov tshuaj tiv thaiv ntawm episodic nco, whereas qhov tseeb ntawm episodic nco tau txhim kho nyob rau hauv cov poj niam, thiab cov tshuaj tiv thaiv lub sij hawm. Kev ua haujlwm nco tau txhim kho hauv cov txiv neej” (5).Qhov kev txhim kho no thaum muaj hnub nyoog me me tuaj yeem txhais ua lub cev thiab lub siab zoo npaj rau cov kev cov nyom ntawm lub hnub nyoog siab.

Alpha-linolenic acid (ALA) yog ib qho omega-3, feem ntau yog los ntawm cov nroj tsuag xws li chia thiab flaxseed ua lwm txoj rau roj marine.ALA yog qhov ua ntej rau DHA, tab sis kev hloov pauv ntau kauj ruam ntawm ALA rau DHA tsis muaj txiaj ntsig rau ntau tus neeg, yog li ua rau kev noj haus DHA tseem ceeb heev rau kev paub txog kev txhawb nqa.ALA, txawm li cas los xij, muaj lwm txoj haujlwm tseem ceeb hauv nws txoj cai.Herb Joiner-Bey, kws pab tswv yim kho mob rau Barlean's, Ferndale, WA, hais tias ALA kuj yog, "siv los ntawm lub hlwb hlwb los ua cov tshuaj hormones hauv zos, suav nrog 'neuroprotectins,' tseem ceeb rau lub hlwb ua haujlwm."Nws hais tias neuroprotectins kuj pom tias muaj tsawg hauv Alzheimer's cov neeg mob thiab hauv kev sim kuaj, ALA tau suav tias yog qhov tseem ceeb rau kev loj hlob ntawm lub hlwb.

Cov laj thawj los xav txog thaum noj cov tshuaj DHA yog ntau npaum li cas thiab bioavailability.Ntau tus neeg tsis tau txais DHA txaus hauv lawv cov zaub mov thiab yuav tau txais txiaj ntsig los ntawm kev noj cov tshuaj ntau ntau lossis ntau dua.Qhov tseem ceeb ntawm kev noj tshuaj tsis ntev los no tau coj los rau hauv kev tshawb fawb tsib xyoos los ntawm Chew li al.uas pom tsis muaj qhov sib txawv tseem ceeb hauv kev paub txog kev ua haujlwm thaum lub sij hawm omega-3 supplementation hauv cov neeg laus (lub hnub nyoog nruab nrab: 72) nrog rau hnub nyoog ntsig txog macular degeneration.Ntau tus kws paub txog khoom noj khoom haus tau tsis ntseeg txog kev tsim qauv.Piv txwv li, Jay Levy, tus thawj coj ntawm kev muag khoom rau Wakunaga of America Co., Ltd., Lub Hom Phiaj Viejo, CA, tau hais tias, "DHA feem tsuas yog 350 mg thaum tsis ntev los no kev tshuaj ntsuam xyuas pom tias DHA niaj hnub noj ntau dua 580 mg yuav tsum tau ua. muab cov txiaj ntsig kev paub txog kev txawj ntse” (6).

Douglas Bibus, Ph.D., ib tug tswv cuab ntawm pawg thawj coj saib xyuas kev tshawb fawb rau Coromega, Vista, CA, tau hais ib tsab xov xwm los ntawm Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv rau EPA thiab DHA Omega-3s (GOED) lub npe hu ua "Omega-3s thiab Cognition: Dosage Matters."Cov pab pawg tau pom, tom qab "kev tshuaj xyuas 20 cov kev tshawb fawb txog kev txawj ntse tau ua nyob rau hauv 10 xyoo dhau los, tsuas yog cov kev tshawb fawb muab 700 mg ntawm DHA lossis ntau dua ib hnub tau tshaj tawm cov txiaj ntsig zoo" (7).

Qee daim ntawv xa tuaj yuav ua rau cov roj marine absorbable.Piv txwv li, Andrew Aussie, tus lwm thawj tswj hwm thiab tus thawj coj ua haujlwm ntawm Coromega, hais tias nws lub tuam txhab tshwj xeeb hauv, "emulsified omega-3 ntxiv uas muab 300% kev nqus zoo dua."Raws li kev tshawb fawb los ntawm Raatz li al.hais tias Aussie cites, lipid emulsification nyob rau hauv lub plab yog ib qho tseem ceeb hauv kev zom cov rog "los ntawm cov tiam ntawm lipid-dej interface tseem ceeb rau kev sib cuam tshuam ntawm dej-soluble lipases thiab insoluble lipids" (8).Yog li, los ntawm emulsifying cov ntses roj, cov txheej txheem no yog bypassed, txhim khu nws absorbability (8).

Lwm qhov cuam tshuam rau bioavailability yog daim ntawv molecular ntawm omega-3.Chris Oswald, DC, CNS, ib tug tswv cuab ntawm pawg thawj coj saib xyuas ntawm Nordic Naturals, Watsonville, CA, ntseeg tias daim ntawv triglyceride ntawm omega-3s muaj txiaj ntsig zoo ntawm kev nce ntshav cov ntshav ntau dua li cov khoom siv hluavtaws.Piv nrog rau cov hluavtaws ethyl ester-bound molecules, daim ntawv ntuj triglyceride tsis tshua muaj zog rau kev zom zaub mov, ua rau nws mus txog 300% ntau absorbable (2).Vim tias nws cov qauv molecular ntawm peb fatty acids txuas rau glycerol qaum, thaum cov roj ntses tau zom, lawv cov ntsiab lus lipid hloov mus rau hauv ib leeg-strand fatty acids.Tom qab absorbed los ntawm lub epithelial hlwb, lawv rov qab mus rau hauv triglycerides.Qhov no yog ua tau los ntawm qhov muaj glycerol qaum, uas ib qho ethyl ester yuav tsis muaj (2).

Lwm lub tuam txhab ntseeg tias phospholipid-bound omega-3s yuav txhim kho kev nqus.Cheryl Meyers, tus thawj coj ntawm kev kawm thiab kev tshawb fawb ntawm EuroPharma, Inc., Greenbay, WI, hais tias cov qauv no "tsis yog tsuas yog ua raws li kev thauj mus los rau omega-3s, tab sis kuj tseem muab kev txhawb nqa hlwb rau lawv tus kheej."Myers piav qhia txog ib qho ntxiv los ntawm nws lub tuam txhab uas muab phospholipid-bound omega-3s rho tawm los ntawm salmon hau (Vectomega).Cov tshuaj ntxiv kuj tseem muaj peptides uas nws ntseeg tias "tuaj yeem tiv thaiv cov hlab ntsha hauv lub hlwb los ntawm kev tawm tsam oxidative puas tsuaj."

Rau cov laj thawj zoo sib xws, qee lub tuam txhab xaiv los tsim cov roj krill, lwm qhov ntawm phospholipid-bound omega-3s uas muaj bioavailability zoo vim lawv cov dej solubility.Lena Burri, tus thawj coj ntawm kev sau ntawv tshawb fawb ntawm Aker Biomarine Antarctic AS, Oslo, Norway, muab cov lus piav qhia ntxiv rau vim li cas daim ntawv no ntawm DHA tseem ceeb heev: ib qho "DHA transporter (Mfsd2a, tus neeg saib xyuas loj super tsev neeg sau muaj 2a) ... lees txais DHA tsuas yog Nws raug khi rau phospholipids - kom meej rau lysoPC" (9).

Ib qho randomized, ob-dig muag, sib piv-pab pawg kev tshawb fawb tau ntsuas qhov cuam tshuam ntawm cov roj krill, sardine roj (triglyceride daim ntawv) thiab cov placebo ntawm kev ua haujlwm nco thiab suav cov haujlwm hauv 45 cov txiv neej laus hnub nyoog 61-72 rau 12 lub lis piam.Los ntawm kev ntsuas cov kev hloov pauv ntawm oxyhemoglobin concentrations thaum lub sijhawm ua haujlwm, cov txiaj ntsig tau pom muaj kev hloov pauv ntau dua hauv cov ntsiab lus hauv ib qho channel tom qab 12 lub lis piam dua li cov placebo, qhia tias kev noj qab haus huv ntev ntawm ob qho tib si krill thiab sardine roj "txhawb kev ua haujlwm nco los ntawm kev ua kom lub dorsolateral prefrontal cortex hauv cov laus. tib neeg, thiab yog li tiv thaiv kev tsis zoo ntawm kev paub txog kev ua haujlwm "(10).

Txawm li cas los xij, hais txog kev suav cov dej num, krill roj "tshwj xeeb ntau dua kev hloov pauv hauv oxyhemoglobin concentrations hauv thaj tsam sab laug," piv rau cov tshuaj placebo thiab sardine roj, uas tsis ua rau muaj kev cuam tshuam rau kev ua haujlwm thaum lub sijhawm ua haujlwm (10).

Lwm yam tshaj li kev pab hauv kev nqus ntawm omega-3s, phospholipids ua lub luag haujlwm tseem ceeb hauv kev paub txog kev noj qab haus huv ntawm lawv tus kheej txoj cai.Raws li Burri, phospholipids tsim txog li 60% ntawm lub hlwb los ntawm qhov hnyav, tshwj xeeb tshaj yog enriched hauv dendrites thiab synapses.Ntxiv rau qhov no, nws hais tias nyob rau hauv vitro, paj hlwb kev loj hlob tsim ib qho kev xav tau ntau ntxiv rau phospholipids thiab paj hlwb kev loj hlob zoo txhawb phospholipid tiam.Ntxiv nrog phospholipids yog siv tau zoo heev thiab muaj txiaj ntsig zoo hauv kev pab kev paub txog kev ua haujlwm vim tias lawv cov qauv zoo ib yam li cov hauv cov paj hlwb.

Ob hom phospholipids yog phosphatidylserine (PS) thiab phosphatidylcholine (PC).Shafat hais tias PS muaj peev xwm thov kev noj qab haus huv tau pom zoo los ntawm US Food and Drug Administration (FDA).Cov ntawv thov suav nrog: "Kev noj PS tuaj yeem txo qis kev pheej hmoo ntawm dementia hauv cov neeg laus," "Kev noj PS tuaj yeem txo qhov kev pheej hmoo ntawm kev paub tsis meej hauv cov neeg laus," thiab tsim nyog nrog, "Kev txwv tsis pub dhau thiab kev tshawb fawb ua ntej qhia tias PS tuaj yeem txo kev pheej hmoo. ntawm dementia / txo qhov kev pheej hmoo ntawm kev paub tsis meej hauv cov neeg laus.FDA xaus lus tias tsis muaj pov thawj kev tshawb fawb me me los txhawb qhov kev thov no. "

Shafat piav qhia tias ntawm nws tus kheej, PS "yog siv tau ntawm koob tshuaj 100 mg / hnub," ib qho me me dua li lwm cov khoom xyaw kev txawj ntse.

Raws li nws txoj haujlwm, Chase Hagerman, tus thawj coj ntawm cov khoom lag luam ntawm ChemiNutra, White Bear Lake, MN, hais tias PS "pab cov proteins uas tswj cov txheej txheem ntawm daim nyias nyias muaj feem cuam tshuam rau kev xa cov lus molecular ntawm cell mus rau cell, pab cov as-ham nkag mus rau hauv lub hlwb, thiab pab. Cov khoom pov tseg uas muaj kev ntxhov siab cuam tshuam rau kev tawm ntawm lub cell. "

PC, ntawm qhov tod tes, xws li uas tsim los ntawm alpha-glyceryl phosphoryl choline (A-GPC), Hagerman hais tias, "migrates mus rau lub paj hlwb synaptic xaus pom thoob plaws hauv lub hauv nruab nrab lub paj hlwb, thiab nyob rau hauv lem, tsub kom lub synthesis thiab tso tawm. acetylcholine (AC)," uas yog ib qho tseem ceeb neurotransmitter "tam sim no nyob rau hauv ob lub hlwb thiab cov nqaij ntshiv nqaij", ua lub luag hauj lwm tseem ceeb nyob rau hauv "qhov tseem ceeb ntawm txhua qhov kev txawj ntse muaj nuj nqi thaum nyob rau hauv cov nqaij nws yog ib qho tseem ceeb rau kev koom tes nyob rau hauv cov leeg nqaij contraction."

Ntau yam khoom ua haujlwm rau qhov kawg no.Dallas Clouatre, Ph.D., R&D tus kws pab tswv yim ntawm Jarrow Formulas, Inc., Los Angeles, CA, piav qhia lawv tias "ib tsev neeg txuas ntxiv ntawm ib qho chaw tshwj xeeb," uas suav nrog uridine, choline, CDP-choline (Citocoline) thiab PC raws li ib feem ntawm lub hlwb lub voj voog qee zaum hu ua Kennedy Cycle.Tag nrho cov tshuaj no ua lub luag haujlwm hauv kev tsim PC hauv lub hlwb thiab yog li kev sib txuas AC.

Kev tsim tawm AC tseem yog lwm yam uas txo qis thaum peb muaj hnub nyoog.Txawm li cas los xij, feem ntau, vim tias cov neurons tsis tuaj yeem tsim lawv tus kheej choline thiab yuav tsum tau txais los ntawm cov ntshav, cov khoom noj uas tsis muaj choline tsim cov khoom tsis txaus ntawm AC (2).Qhov tsis muaj choline muaj nyob rau hauv kev loj hlob ntawm cov kab mob xws li Alzheimer's thiab hnub nyoog txog kev paub txog kev poob qis.Kev ua haujlwm ntawm tus kws tshawb fawb Richard Wurtman, MD, los ntawm Massachusetts Institute of Technology tau tawm tswv yim tias vim tias tsis txaus choline, lub hlwb tuaj yeem ua rau PC los ntawm nws tus kheej neural membrane los ua AC (2).

Neil E. Levin, CCN, DANLA, tus thawj saib xyuas kev noj haus ntawm NOW Foods, Bloomingdale, IL piav qhia txog cov qauv "uas txhawb kev puas siab puas ntsws thiab kev kawm los ntawm kev txhawb nqa AC ntau lawm thiab kev ua haujlwm," los ntawm kev sib txuas A-GPC, "cov ntaub ntawv bioavailable ntawm choline ,” nrog Huperzine A kom tswj tau qib AC (RememBRAIN los ntawm NOW Foods).Huperzine A tswj AC los ntawm kev ua haujlwm raws li kev xaiv inhibitor ntawm acetylcholinesterase, uas yog ib qho enzyme uas ua rau kev tawg ntawm AC (11).

Raws li Levy, citicoline yog ib qho ntawm cov khoom xyaw tshiab rau kev txhawb nqa kev paub, tsom mus rau lub ntsej muag lobe, uas yog thaj chaw lub luag haujlwm rau kev daws teeb meem, kev mloog thiab kev xav.Nws hais tias ntxiv nrog citicoline hauv cov neeg laus tau pom tias "kev txhim kho kev hais lus, kev nco thiab kev paub, kev saib xyuas, ntshav ntws mus rau lub hlwb thiab kev ua haujlwm bioelectrical."Nws hais txog ntau qhov kev tshawb fawb uas tau pom cov txiaj ntsig zoo, suav nrog ob qhov muag tsis pom kev, randomized, kev sim tshuaj placebo ntawm 30 Alzheimer's cov neeg mob uas tau pom tias muaj kev paub zoo dua qub piv rau cov placebo tom qab noj citicoline txhua hnub, tshwj xeeb tshaj yog cov neeg mob me me dementia (12).

Elyse Lovett, tus thawj saib xyuas kev lag luam ntawm Kyowa USA, Inc., New York, NY, hais tias nws lub tuam txhab muaj "tsuas yog kev tshuaj xyuas cov ntawv citicoline rau cov neeg laus noj qab haus huv thiab cov hluas," thiab nws yog "tsuas yog citicoline nrog GRAS [feem ntau. lees paub tias muaj kev nyab xeeb] xwm txheej hauv Tebchaws Meskas” (Cognizin).

Lwm yam ntxiv ntxiv, raws li Dan Lifton, tus thawj tswj hwm ntawm Maypro's Proprietary Branded Ingredients Group, Purchase, NY, yog INM-176 muab los ntawm lub hauv paus Angelica gigas Nakai, uas kuj tau pom los txhawb kev paub txog kev noj qab haus huv los ntawm kev nce lub hlwb ntawm AC.

Cov vitamin tsis txaus feem ntau tshwm sim lawv tus kheej los ntawm kev poob qis hauv kev paub txog kev ua haujlwm.Piv txwv li, vitamin B12 deficiency tuaj yeem suav nrog cov tsos mob xws li tsis meej pem, nco tsis tau, hloov tus cwj pwm, paranoia, kev nyuaj siab thiab lwm yam kev coj cwj pwm zoo li dementia.Tsis tas li ntawd xwb, tab sis 15% ntawm cov neeg laus thiab ntau npaum li 40% ntawm cov neeg mob uas muaj hnub nyoog 60 xyoo muaj qis lossis ciam teb B12 qib (13).

Raws li Mohajeri li al., B12 plays lub luag haujlwm tseem ceeb hauv kev hloov homocysteine ​​(Hcy) rau hauv cov amino acid methionine, tab sis lwm cov vitamins B folate (B9) thiab B6 yog cov tsim nyog cofactors rau metabolization tshwm sim, tsis muaj qhov twg, Hcy accumulates.Hcy yog ib qho amino acid tsim nyob rau hauv lub cev los ntawm kev noj haus methionine thiab yog ib qho tseem ceeb rau ib txwm cellular muaj nuj nqi, tab sis siab concentrations ntawm nws undermine hais tias ua hauj lwm (14).Michael Mooney, tus thawj coj ntawm kev tshawb fawb thiab kev kawm ntawm SuperNutrition, Oakland, CA hais tias "cov ntshav siab ntawm homocysteine ​​tau pom tias ua rau muaj kev puas tsuaj rau kev nco thiab ntau yam ntawm kev paub txog kev ua haujlwm."

Mohajeri et al.txhawb cov nqe lus no: "Qhov hnyav ntawm kev puas siab puas ntsws tau cuam tshuam nrog kev nce siab ntawm Hcy plasma.Ntxiv mus, muaj kev pheej hmoo siab dua ntawm Alzheimer's kab mob tau tshaj tawm thaum ob qho tib si folate thiab B12 qib qis "(15).

Niacin yog lwm cov vitamin B uas txhawb kev nco thiab kev paub txog kev ua haujlwm.Raws li Mooney, niacin, ntau hom vitamin B3, feem ntau yog muab los ntawm cov kws kho mob ntawm 1,000 mg lossis ntau dua ib hnub los txhawb cov qib roj cholesterol ib txwm, tab sis txoj kev tshawb nrhiav placebo tau pom tias noj zaub mov noj 425 mg ib hnub twg txhim kho kev nco. xeem cov qhab nia los ntawm ntau npaum li 40% nrog rau kev txhim kho kev hnov ​​​​lus sau npe los ntawm ntau npaum li 40%.Thaum lub zog ntau dua, niacin kuj tau pom tias yuav txhim kho cov ntshav hauv hlwb, "uas ua rau cov khoom noj thiab cov pa oxygen hauv lub hlwb nce ntxiv," nws hais ntxiv (16).

Ntxiv rau niacin, Mooney piav txog niacinamide, uas yog lwm hom vitamin B3.Ntawm 3,000 mg / hnub, niacinamide tau kawm los ntawm UC Irvine raws li kev kho mob rau Alzheimer's thiab nco tsis tau cuam tshuam nrog nws tom qab tau txais txiaj ntsig zoo hauv kev tshawb fawb nas.Ob daim ntawv, nws piav qhia, hloov hauv lub cev mus rau hauv NAD +, ib qho molecule uas tau pom tias rov qab kev laus hauv mitochondria, qhov tseem ceeb ntawm cov cellular zog tsim."Qhov no yuav yog ib qho tseem ceeb rau cov vitamin B3's nco boosting thiab lwm yam los tiv thaiv kev laus," nws hais.

Lwm qhov ntxiv los qhia cov neeg siv khoom yog PQQ.Clouatre hais tias nws tau txiav txim siab los ntawm qee tus tsuas yog cov vitamin tshiab uas pom nyob rau hauv ob peb lub xyoo dhau los, uas qhia tau zoo hauv thaj chaw xws li neuroprotection."PQQ inhibits ntau tiam ntawm ntau cov radicals, suav nrog peroxynitrite radical uas muaj kev phom sij heev," nws hais tias, thiab hauv PQQ tau pom cov txiaj ntsig zoo hauv kev kawm thiab kev nco hauv tsiaj thiab tib neeg kev tshawb fawb.Ib qho kev sim tshuaj pom tau tias kev sib xyaw ntawm 20 mg ntawm PQQ thiab CoQ10 tau txais txiaj ntsig zoo hauv tib neeg cov ntsiab lus hauv kev nco, kev xav thiab kev paub (17).

Lifton hais tias zoo li niacin, PQQ thiab CoQ10 txhawb nqa mitochondrial muaj nuj nqi.Nws hais tias CoQ10 ua li ntawd los ntawm kev tiv thaiv "mitochondria tshwj xeeb los ntawm kev puas tsuaj los ntawm kev tawm tsam dawb-radical tsis tu ncua," ntxiv rau "kev tsim hluav taws xob ntawm tes, uas yuav ua rau muaj zog ntau ntxiv rau cov txheej txheem kev txawj ntse."Qhov no yog qhov tseem ceeb vim tias "kev tshawb fawb tshiab zoo siab qhia tias ib qho ntawm cov laj thawj tseem ceeb ntawm cov teeb meem kev nco me me cuam tshuam nrog kev laus yog kev puas tsuaj rau peb cov mitochondria," hais tias Lifton.

Magnesium yog cov ntxhia tseem ceeb rau kev tswj xyuas kev paub zoo, lossis rau qhov teeb meem ntawd, lub cev ua haujlwm tag nrho.Raws li Carolyn Dean, MD, ND, tus kws tshaj lij pab tswv yim kho mob ntawm Lub Koom Haum Noj Qab Haus Huv Magnesium, "Magnesium ib leeg yog xav tau nyob rau hauv 700-800 txawv enzyme systems" thiab "ATP (adenosine triphosphate)) ntau lawm nyob rau hauv Krebs voj voog nyob ntawm magnesium rau rau. ntawm nws yim kauj ruam. "

Ntawm kev paub txog pem hauv ntej, Dean hais tias magnesium blocks neuro-mob mob tshwm sim los ntawm kev tso nyiaj ntawm calcium thiab lwm yam hlau hnyav hauv hlwb hlwb nrog rau kev tiv thaiv ion channel thiab thaiv cov hlau hnyav los ntawm kev nkag mus.Nws piav qhia tias thaum magnesium tsawg, calcium rushes rau hauv thiab ua rau cell tuag.Levin hais ntxiv, "Kev tshawb fawb tsis ntev los no tau pom tias nws tseem ceeb heev rau lub hlwb kev noj qab haus huv thiab kev paub txog kev ua haujlwm los ntawm kev tswj xyuas qhov ceev thiab ruaj khov ntawm neuronal synapses."

Hauv nws phau ntawv Magnesium Miracle, Dean piav qhia tias qhov tsis txaus ntawm magnesium ib leeg tuaj yeem tsim cov tsos mob ntawm dementia.Qhov no yog qhov tseeb tshwj xeeb tshaj yog thaum peb muaj hnub nyoog, txij li lub cev muaj peev xwm nqus tau magnesium los ntawm peb cov zaub mov txo qis thiab tseem tuaj yeem cuam tshuam los ntawm cov tshuaj ntau hauv cov neeg laus (18).Yog li, magnesium qib hauv cov ntshav tuaj yeem txo qis vim tias lub cev tsis muaj peev xwm nqus cov ntxhia, noj zaub mov tsis zoo thiab tshuaj noj, tsim kom muaj calcium thiab glutamate ntau dhau (tshwj xeeb yog noj cov zaub mov siab hauv MSG), ob qho tib si muaj lub luag haujlwm ua si. nyob rau hauv mob neural degeneration thiab kev loj hlob ntawm dementia (19).

Txawm hais tias cov khoom noj muaj txiaj ntsig tseem ceeb rau kev tswj hwm kev noj qab haus huv kev paub txog kev ua haujlwm, cov tshuaj ntsuab tuaj yeem pab txhawb ntxiv rau ntau yam peev xwm.Kev paub txog hnub nyoog txog kev poob qis thiab kev dementia tuaj yeem tsim nyob rau hauv ntau txoj hauv kev, nrog txo cov ntshav cerebral yog ib qho ntawm cov txheej txheem sib txawv.Ob peb tshuaj ntsuab ua haujlwm los tawm tsam qhov xwm txheej no.Nws yuav tsum raug sau tseg tias tshuaj ntsuab uas txhim kho cov ntshav ncig tuaj yeem ua rau muaj kev phom sij rau cov neeg siv khoom uas twb tau noj cov tshuaj uas txo cov ntshav siab xws li warfarin.

Lub luag haujlwm tseem ceeb ntawm Gingko biloba yog nce cov ntshav hauv hlwb, uas ua lub luag haujlwm loj hauv kev txhim kho dementia txawm tias pib los ntawm Alzheimer's lossis kab mob cerebrovascular.Nws kuj tau hais tias kom rov ua haujlwm tsis zoo mitochondrial los txhim kho cov khoom siv hluav taws xob neuronal, nce choline uptake hauv hippocampus, inhibit kev sib sau thiab tshuaj lom ntawm b-amyloid protein thiab muaj cov teebmeem antioxidant (20, 21).

Levy hais txog plaub lub lis piam sim kev tshawb fawb hauv Neuroradiology uas "qhia tawm plaub mus rau xya feem pua ​​​​ntawm cov ntshav cerebral ntws ntawm ib koob tshuaj ntawm 120 mg ib hnub twg" ntawm gingko (22).Ib qho kev sib cais, kev tswj hwm cov placebo, ob qhov muag tsis pom kev kawm txiav txim siab txog kev ua tau zoo thiab kev nyab xeeb ntawm gingko biloba rau cov neeg mob uas muaj kev paub tsis meej thiab cov tsos mob neuropsychiatric (NPS) los ntawm Gavrilova li al., pom tias "thaum lub sijhawm 24-lub lim tiam ntawm kev kho mob, Kev txhim kho hauv NPS thiab kev txawj ntse muaj peev xwm tseem ceeb thiab tsis tu ncua hauv cov neeg mob noj 240 mg ib hnub ntawm G. biloba extract EGb 761 dua li cov neeg mob noj cov placebo "(23).

Qhov kev ua tau zoo ntawm gingko biloba tseem raug sim rau lwm yam mob xws li kev tsis txaus siab tsis txaus ntseeg siab (ADHD) hauv cov menyuam yaus.Ib qho kev txwv tab sis kev vam meej los ntawm Sandersleben li al.tau tshaj tawm tias tom qab ntxiv nrog gingko, "kev txhim kho tseem ceeb tau pom rau cov niam txiv qhov kev ntsuam xyuas ntawm lawv cov me nyuam txoj kev mob siab rau ... hyperactivity, impulsivity, thiab tag nrho cov qhab nia ntawm cov tsos mob hnyav tau txo qis," thiab, "kev txhim kho tseem ceeb ntawm kev coj tus cwj pwm zoo" (24) .Vim tias txoj kev tshawb fawb muaj kev txwv, xws li tsis muaj kev tswj hwm lossis tus qauv loj dua, tsis muaj qhov kev txiav txim siab zoo tuaj yeem rub tawm ntawm nws txoj kev ua tau zoo, tab sis cia siab tias nws yuav txhawb kom cov ncauj lus kom ntxaws ntxiv, tswj kev sim.

Lwm cov tshuaj ntsuab uas ua haujlwm zoo ib yam yog Bacopa monniera uas, raws li Levy, kev tshawb fawb tsiaj tsis ntev los no hauv Phytotherapy Kev Tshawb Fawb tau pom tias "25% nce hauv cov ntshav ntws mus rau lub hlwb ntawm cov tsiaj noj 60 mg ntawm bacopa monniera txhua hnub piv rau tsis muaj kev nce ntxiv hauv cov neeg uas tau muab ua tiav. ” (25).

Nws kuj tau hais tias muaj cov tshuaj antioxidant.Raws li Shaheen Majeed, tus thawj coj lag luam ntawm Sabinsa Corp., East Windsor, NJ, bacopa "inhibits lipid peroxidation thiab yog li tiv thaiv kev puas tsuaj rau cortical neurons."Lipid peroxidation tshwm sim thaum lub sij hawm oxidative kev nyuaj siab txuam nrog DHA deficiency, uas, dua, yog cov tsos mob ntawm Alzheimer's.

Mary Rove, ND, tus kws qhia kho mob ntawm Gaia Herb, Brevard, NC, kuj hais txog kev ntxiv lawv cov tshuaj Gingko nrog tshuaj ntsuab xws li peppermint thiab rosemary.Raws li nws, peppermint txhawb kev ceeb toom thiab "kev tshawb fawb tau honed nyob rau hauv rosmaranic acid, ib tug active constituent nrog antioxidant zog."Hloov tawm, nws hais ntxiv, "muaj ntau cov ntaub ntawv niaj hnub los tuav cov lus hais me me 'rosemary rau kev nco qab."

Huperzine A, tau hais yav dhau los rau nws txoj haujlwm ua acetylcholinesterase inhibitor, yog muab los ntawm Suav tshuaj ntsuab Huperzia serrata.Nws lub peev xwm los tiv thaiv kev tawg ntawm acetylcholine zoo ib yam li cov tshuaj FDA pom zoo pom zoo los kho cov tsos mob ntawm Alzheimer's kab mob xws li donepezil, galantamine thiab rivastigmine, uas yog cholinesterase inhibitors (11).

Ib qho kev tshuaj ntsuam meta ua los ntawm Yang et al.xaus lus, "Huperzine A zoo li muaj qee qhov txiaj ntsig ntawm kev txhim kho kev paub txog kev ua haujlwm, kev ua neej nyob txhua hnub thiab kev soj ntsuam thoob ntiaj teb hauv cov neeg koom nrog Alzheimer's disease."Lawv tau ceeb toom, txawm li cas los xij, qhov kev tshawb pom yuav tsum tau txhais ua tib zoo saib vim qhov tsis zoo ntawm cov txheej txheem kev sim, thiab tau thov kom muaj kev sim nruj ntxiv (11).

Antioxidants.Ntau ntawm cov tshuaj sib tham muaj peev xwm antioxidant, uas pab ua rau lawv zoo tiv thaiv kev puas hlwb, uas oxidative stresses feem ntau ua rau.Raws li Meyers, "Nyob rau hauv txhua yam kab mob hauv lub hlwb, qhov mob yog qhov tseem ceeb - nws hloov qhov xwm txheej ntawm cov hlwb cuam tshuam nrog ib leeg."Tias yog vim li cas thiaj li muaj qhov muaj koob npe nrov thiab kev tshawb fawb txog curcumin, uas yog cov khoom sib xyaw tau los ntawm turmeric, pom tias yuav txo qis kev mob thiab oxidative puas hauv lub hlwb thiab txhawb kev tua cov neurons, hais tias Meyers.

Hauv cov xwm txheej xws li Alzheimer's, curcumin yuav muaj peev xwm cuam tshuam rau kev tsim cov beta-amyloid.Ib txoj kev tshawb fawb los ntawm Zhang li al., uas tau sim curcumin ntawm cov kab lis kev cai ntawm tes thiab nas thawj cortical neurons, pom tias cov tshuaj ntsuab txo qis beta-amyloid los ntawm kev ua kom qeeb ntawm kev loj hlob ntawm amyloid-beta precursor protein (APP).Nws attenuated APP maturation los ntawm ib txhij ua kom ruaj ntseg ntawm APP tsis paub qab hau thiab txo stability ntawm mature APP (26).

Kev tshawb fawb ntxiv yuav tsum tau ua kom nkag siab zoo txog cov txiaj ntsig curcumin tuaj yeem muaj rau kev paub thiab yuav ua li cas nws tuaj yeem txhim kho kev txawj ntse.Tam sim no, McCusker Alzheimer's Research Foundation tab tom txhawb kev tshawb fawb ntawm Edith Cowan University hauv Perth, Australia, txhawm rau ntsuas qhov ua tau zoo ntawm curcumin rau cov neeg mob uas muaj kev puas hlwb me me.Txoj kev tshawb no 12 lub hlis yuav soj ntsuam seb cov tshuaj ntsuab puas yuav khaws cov neeg mob kev paub txog kev ua haujlwm.

Lwm qhov muaj zog antioxidant uas txhawb kev txawj ntse yog Pycnogenol (muab los ntawm Horphag Research).Dhau li ntawm kev ua kom muaj zog tiv thaiv oxidative kev puas tsuaj, cov tshuaj ntsuab, uas yog muab los ntawm Fabkis maritime ntoo thuv bark, kuj tau pom los txhim kho cov ntshav ncig, nrog rau microcirculation nyob rau hauv lub hlwb raws li zoo raws li nce zus tau tej cov nitric oxide, uas ua raws li ib tug neurotransmitter. , tejzaum nws ua rau kev nco thiab kev kawm muaj peev xwm (25).Hauv ib txoj kev kawm yim-lub lim tiam, cov kws tshawb fawb tau muab 53 tus tub ntxhais kawm muaj hnub nyoog ntawm 18 txog 27 Pycnogenol thiab ntsuas lawv qhov kev ua tau zoo ntawm qhov kev sim tiag tiag.Cov txiaj ntsig tau pom tias pawg neeg sim ua tsis tau qhov kev sim tsawg dua li kev tswj hwm (xya vs. cuaj) thiab ua tau 7.6% zoo dua li kev tswj hwm (27).WF

1. Joseph C. Maroon thiab Jeffrey Bost, Ntses Roj: Lub Ntuj Tiv Thaiv Kab Mob.Basic Health Publications, Inc. Laguna Beach, California.2006. 2. Michael A. Schmidt, Brian-Building Nutrition: How Dietary Fats and Oils Affect Mental, Physical, and Emotional Intelligence, Third Edition.Frog Books, Ltd. Berkeley, California, 2007. 3. J. Thomas li al., “Omega-3 fatty ccids in early prevention of inflammatory neurodegenerative disease: A focus on Alzheimer's disease.”Hindawa Publishing Corporation, BioMed Research International, Volume 2015, Tshooj ID 172801. 4. K. Yurko-Mauro li al., "Cov txiaj ntsig zoo ntawm docosahexaenoic acid rau kev paub txog kev paub txog hnub nyoog txog kev poob qis." Alzheimers Dement.6(6): 456-64.2010. 5. W. Stonehouse li al., "DHA supplementation txhim kho ob qho tib si nco thiab cov tshuaj tiv thaiv lub sij hawm nyob rau hauv cov hluas noj qab haus huv: ib tug randomized tswj mus sib hais."Am J Clin Nutr.97:1134-43.2013. 6. EY Chew et al., "Cov nyhuv ntawm omega-3 fatty acids, lutein/zeaxanthin, los yog lwm yam as-ham supplementation ntawm kev txawj ntse muaj nuj nqi: lub AREDS2 randomized soj ntsuam kuaj."JAMA.314(8): 791-801.2015. 7. Adam Ismail, “Omega-3s and cognition: dosage matters.”http://www.goedomega3.com/index.php/blog/2015/08/omega-3s-and-cognition-dosage-matters.8. Susan K. Raatz li al., "Txhim kho qhov nqus ntawm omega-3 fatty acids los ntawm emulsified piv nrog cov roj ntses encapsulated."J Am Diet Assoc.109(6).1076-1081 Ib.2009. 9. LN Nguyen et al., "Mfsd2a yog ib qho kev thauj mus rau qhov tseem ceeb omega-3 fatty acid docosahexaenoic acid."http://www.nature.com/nature/journal/v509/n7501/full/nature13241.html 10. C. Konagai et al., “Cov teebmeem ntawm cov roj krill uas muaj n-3 polyunsaturated fatty acids hauv phospholipid daim ntawv ntawm tib neeg lub hlwb muaj nuj nqi: ib qho kev soj ntsuam randomized hauv cov neeg laus noj qab haus huv tuaj yeem pab dawb. "Clin Interv Aging.8: 1247-1257.2013. 11. Guoyan Yang et al., "Huperzine A rau Alzheimer's disease: ib qho kev tshuaj xyuas thiab kev tshuaj xyuas meta-kev soj ntsuam ntawm randomized soj ntsuam."PLOS IB.8(9).2013. 12. XA.Alvarez et al."Kev kawm ob qhov muag tsis pom kev placebo-tswj nrog citicoline hauv APOE genotyped Alzheimer's cov neeg mob: Cov teebmeem ntawm kev paub txog kev ua tau zoo, lub hlwb bioelectrical kev ua haujlwm thiab cerebral perfusion."Txoj Kev Nrhiav Exp Clin Pharmacol.21(9):633-44.1999. 13. Sally M. Pacholok thiab Jeffrey J. Stuart.Nws puas tuaj yeem yog B12: Tus Kab Mob Sib Kis ntawm Misdiagnosis, Thib Ob.Quill Driver Books.Fresno, CA.2011. 14. M. Hasan Mohajeri et al., "Kev tsis txaus ntawm cov vitamins thiab DHA rau cov neeg laus: Kev cuam tshuam rau lub hlwb laus thiab Alzheimer-type dementia."Khoom noj khoom haus.31:261-75.2015. 15. WM.Loriaux et al."Qhov cuam tshuam ntawm nicotinic acid thiab xanthinol nicotinate rau tib neeg nco hauv ntau pawg hnub nyoog.Kev tshawb nrhiav ob qhov muag tsis pom.”Psychopharmacology (Berl).867 (4): 390-5.1985. 16. Steven Schreiber, "Kev Tshawb Fawb Txog Kev Nyab Xeeb ntawm Nicotinamide los kho Alzheimer's Disease."https://clinicaltrials.gov/ct2/show/NCT00580931?term=nicotinamide+alzheimer%27s&rank=1.17. Koikeda T. et al.al, "Pyrroloquinoline quinone disodium ntsev txhim kho lub hlwb ntau dua."Kev Sib Tham Txog Kev Kho Mob thiab Kev Kho Tshiab.48(5): 519. 2011. 18. Carolyn Dean, Magnesium Miracle.Ballantine Phau Ntawv, New York, NY.2007. 19. Dehua Chui et al., “Magnesium in Alzheimer's disease.”Magnesium hauv Central Nervous System.University of Adelaide Xovxwm.2011. 20. S. Gauthier thiab S. Schlaefke, "Kev ua tau zoo thiab kev kam rau siab ntawm Gingko biloba extract Egb 761 hauv kev dementia: kev tshuaj xyuas thiab kev tshuaj xyuas meta-kev sim ntawm randomized placebo-tswj kev sim."Clinical Interventions in Aging.9: 2065-2077 .2014. 21. T. Varteresian thiab H. Lavretsky, “Natural products and supplements for geriatric depression and cognitive disorders: an evaluation of research.Curr Psychiatry Rep. 6(8), 456. 2014. 22. A. Mashayekh, et al., "Cov teebmeem ntawm Ginkgo biloba ntawm cov hlab ntsha ntawm lub paj hlwb raug soj ntsuam los ntawm quantitative MR perfusion imaging: pilot study."Neuroradiology.53(3):185-91 : kuv.2011. 23. SI Gavrilova, et al., "Kev ua tau zoo thiab kev nyab xeeb ntawm Gingko biloba extract EGb 761 hauv kev paub tsis meej me ntsis nrog cov tsos mob neuropsychiatric: ib qho randomized, placebo tswj, ob-dig muag, multicenter sim."Int J Geriatr Psychiatry.29:1087-1095 : kuv.2014. 24. HU Sandersleben et al., "Gingko biloba extract EGb 761 nyob rau hauv cov me nyuam nrog ADHD."Z. Kinder-Jugendpsychiatr.Psychother.42 (5): 337-347.2014. 25. N. Kamkaew, et al., "Bacopa monnieri nce cerebral blood flow in rat indpendent of blood pressure."Phytother Res.27(1):135-8.2013. 26. C. Zhang, et al., "Curcumin txo qis amyloid-beta peptide theem los ntawm attenuating lub maturation ntawm amyloid-beta precursor protein."J Biol Chem.285(37): 28472-28480.2010. 27. Richard A. Passwater, Tus Neeg Siv Phau Ntawv Qhia rau Pynogenol Nature's Most Versatile Supplement.Basic Health Publications, Laguna Beach, CA.2005. 28. R. Lurri, et al., "Pynogenol supplementation txhim kho kev txawj ntse, kev mloog lus thiab kev xav ntawm cov menyuam kawm ntawv."J Neurosurg Sci.58(4): 239-48.Xyoo 2014.

Tshaj tawm hauv WholeFoods Magazine Lub Ib Hlis 2016

WholeFoods Magazine yog koj qhov chaw ib-nres rau kev noj qab haus huv thiab khoom noj khoom haus tam sim no, suav nrog gluten dawb txoj kev ua neej thiab xov xwm kev noj haus.

Lub hom phiaj ntawm peb cov khoom noj qab haus huv thiab khoom noj khoom haus yog qhia rau cov neeg muag khoom thiab cov neeg muag khoom txog cov khoom tshiab thiab cov khoom noj khoom haus tshiab tshaj plaws, yog li lawv tuaj yeem ua kom zoo dua ntawm cov cib fim tshiab thiab txhim kho lawv cov lag luam.Peb cov ntawv xov xwm muab cov ntaub ntawv tseem ceeb hais txog kev lag luam cov khoom lag luam tshiab thiab tawm tshiab, ntxiv rau kev tshawb fawb tom qab cov khoom noj tseem ceeb.