Pyrroloquinoline Quinone Disodium nnu (PQQ)

Ọtụtụ ihe na-emetụta ahụ ike anyị.Ndị na-azụ ahịa nwere ike ọ gaghị ejikọta ahụike ọgụgụ isi ozugbo na ọdịmma ha niile, mana ahụike uche, anụ ahụ na ọbụna nke mmetụta uche na-ejikọta ya nke ukwuu.E gosiputara nke a n'ụzọ na ụkọ nri dị iche iche nwere ike ibute mbelata ọrụ ọgụgụ isi (dịka, B12 na magnesium).

Ọ na-apụtakwa ìhè ka anyị na-aka nká.Ka anyị na-akawanye nká, ahụ́ na-adị ntakịrị ihe oriri na-edozi ahụ, nke nwere ike ịkpata erughị eru.Ọ dị mfe ịhapụ ichefu na enweghị uche dị ka ihe mgbaàmà nke afọ, nke ha bụ, ma ha bụkwa ihe mgbaàmà nke ọnọdụ ahụ anyị dum n'ihi ịka nká.Mgbakwunye, site n'ịmepụta mperi na nri, nwere ike imeziwanye ọrụ ọgụgụ isi.Nke a bụ ụfọdụ nri akọwapụtara nke metụtara ahụike ọgụgụ isi.

Otu ụzọ n'ụzọ atọ nke ụbụrụ bụ polyunsaturated fatty acids (PUFA), na-aza 15-30% nke arọ akọrọ nke ụbụrụ, yana docosahexaenoic acid (DHA) na-eme ihe dị ka otu ụzọ n'ụzọ atọ nke (1).

DHA bụ omega-3 fatty acid nke na-arụ ọrụ dị mkpa na ụbụrụ, na-etinye uche n'akụkụ ụbụrụ nke chọrọ ogo eletrik kachasị elu, gụnyere synaptosomes ebe njedebe akwara na-ezute ma na-ekwurịta okwu, mitochondria, nke na-emepụta ike maka ya. mkpụrụ ndụ akwara, na cortex cerebral, nke bụ oyi akwa mpụta nke ụbụrụ (2).O doro anya na DHA bụ ihe dị mkpa maka mmepe ụbụrụ nwa na ụmụaka na ọ dị oke mkpa n'oge ndụ niile maka ịnọgide na-enwe ahụike ọgụgụ isi.Mkpa DHA dị ka anyị na-eme agadi na-apụta ìhè mgbe ị na-ele ndị na-emetụta afọ ndụ ndị metụtara afọ, dị ka ọrịa Alzheimer (ụdị nkwarụ nke na-ebute ebe nchekwa na-aga n'ihu, ọgụgụ isi na ọdịda omume).

Dabere na nyocha nke Thomas et al., "N'ime ndị ọrịa a chọpụtara na ha nwere ọrịa Alzheimer, achọpụtara ọkwa DHA dị ntakịrị na plasma ọbara na ụbụrụ.Ọ bụghị naanị na nke a nwere ike ịbụ n'ihi obere nri omega-3 fatty acids, mana enwere ike ịsị ya na mmụba oxidation nke PUFAs"(3).

N'ebe ndị ọrịa Alzheimer nọ, a na-eche na ọ bụ protein beta-amyloid kpatara mbelata ọgụgụ isi, nke na-egbu egbu na mkpụrụ ndụ akwara.Mgbe ọkwa nke protein a na-abawanye, ha na-ebibi nnukwu traktị nke mkpụrụ ndụ ụbụrụ, na-ahapụ ihe amyloid plaques nke metụtara ọrịa ahụ (2).

Nnyocha dị iche iche egosila na DHA nwere ike inwe mmetụta neuroprotective site na ibelata beta-amyloid toxicity na site n'inye mmetụta mgbochi mkpali nke nwere ike ibelata amyloid plaque nke kpatara nrụgide oxidative na ibelata ọkwa nke protein oxidized site na 57% (2).Ọ bụ ezie na ụkọ DHA na ndị na-arịa ọrịa Alzheimer nwere ike inwe mmetụta ụfọdụ maka otú mgbakwunye nwere ike isi baara ha uru, ekwesịrị iburu n'uche na mgbakwunye enweghị ike ịgwọ ọrịa a ma ọ bụ ọrịa ọ bụla na ọmụmụ ihe na-ekwu banyere isiokwu ahụ nwere ihe mgbagwoju anya.

Ihe mgbakwunye abụghị ọgwụ, na eziokwu bụ na ndị ọrịa Alzheimer torola agadi ga-erite uru nke kacha nta site na DHA ma ọ bụ ihe ndị ọzọ na-edozi ahụ maka nkwado nghọta n'ihi na mgbe a chọpụtara ha, mmebi anụ ahụ emelarị ụbụrụ.

Ka o sina dị, ụfọdụ ndị nchọpụta na-enyocha ma ihe mgbakwunye DHA nwere ike belata ọganihu nke ịda mbà n'obi.Itay Shafat Ph.D., ọkà mmụta sayensị dị elu maka ngalaba na-edozi ahụ na Enzymotec, Ltd., na ụlọ ọrụ US na Morristown, NJ, na-ehota ihe ọmụmụ nke Yourko-Mauro et al.nke chọpụtara, "Mgbakwunye nke 900 mg / ụbọchị DHA maka izu 24, na isiokwu ndị dị afọ> 55 nwere oke ọgụgụ isi, mere ka ncheta ha na nkà mmụta dịkwuo mma" (4).

Ọ bụ ezie na ụfọdụ ndị na-azụ ahịa nwere ike ọ gaghị eche banyere ahụike uche ruo mgbe nsogbu bilitere, ọ bụ isi ihe maka ndị na-ere ahịa na-echetara ha mkpa DHA maka ụbụrụ n'oge ndụ niile.N'ezie, DHA nwere ike ịkwado ahụike ahụike nke ndị na-eto eto nwere ahụike na enweghị ụkọ nri doro anya.Nnwale a na-achịkwa n'oge na-adịbeghị anya site n'aka Stonehouse et al., Na-amụ 176 ndị okenye ahụike dị afọ 18 ruo 45, chọpụtara, "Mgbakwunye DHA mere ka oge mmeghachi omume nke ebe nchekwa episodic dịkwuo mma, ebe a na-emeziwanye ebe nchekwa episodic n'ime ụmụ nwanyị, na oge mmeghachi omume nke A na-eme ka ebe nchekwa ọrụ dịkwuo mma n'ime ụmụ nwoke" (5).Ọganihu a n'oge dị obere nwere ike ịtụgharị n'ime ahụ na uche nke a kwadebere nke ọma maka ihe ịma aka nke ịka nká.

Alfa-linolenic acid (ALA) bụ omega-3, nke a na-esi na osisi dị ka chia na flaxseed dị ka ihe ọzọ na mmanụ mmiri.ALA bụ ihe mmalite maka DHA, mana ntụgharị ọtụtụ nzọụkwụ site na ALA gaa DHA adịghị arụ ọrụ n'ọtụtụ mmadụ, si otú a na-eme DHA nri nri dị mkpa maka nkwado nghọta.Otú ọ dị, ALA nwere ọrụ ndị ọzọ dị mkpa n'onwe ya.Herb Joiner-Bey, onye ndụmọdụ sayensị ahụike maka Barlean's, Ferndale, WA, na-ekwu na ALA na-ejikwa “sel ụbụrụ na-eme homonụ mpaghara, gụnyere 'neuroprotectins,' dị mkpa maka ịrụ ọrụ ụbụrụ."Ọ na-ekwu na a na-ahụkwa neuroprotectins dị ala na ndị ọrịa Alzheimer na na nyocha ụlọ nyocha, ALA weere na ọ dị mkpa maka mmepe ụbụrụ.

Ihe ndị ị ga-atụle mgbe ị na-ewere mgbakwunye DHA bụ usoro onunu ogwu na bioavailability.Ọtụtụ ndị mmadụ anaghị enweta DHA zuru oke na nri ha, ha ga-eritekwa uru site na ị theụ ọgwụ siri ike ma ọ bụ karịa.Ewetara mkpa usoro onunu ogwu n'oge na-adịbeghị anya na nyocha afọ ise nke Chew et al.nke ahụghị ọdịiche dị ịrịba ama na ọrụ ọgụgụ isi n'oge omega-3 supplementation na ndị agadi (pụtara afọ: 72) na-emetụta macular degeneration.Ọtụtụ ndị ọkachamara n'ihe banyere nri na-enwe obi abụọ maka nhazi ọmụmụ.Dịka ọmụmaatụ, Jay Levy, onye isi ahịa nke Wakunaga of America Co., Ltd., Mission Viejo, CA, kwuru, "Ihe akụrụngwa DHA bụ naanị 350 mg ebe meta-analysis na nso nso a chọpụtara na a chọrọ dose DHA kwa ụbọchị karịa 580 mg. na-enye uru ọrụ ọgụgụ isi" (6).

Douglas Bibus, Ph.D., onye otu bọọdụ ndụmọdụ sayensị maka Coromega, Vista, CA, zoro aka na akụkọ sitere na Global Organisation for EPA na DHA Omega-3s (GOED) akpọrọ "Omega-3s na Cognition: Dosage Matters."Ndị otu ahụ chọpụtara, mgbe ha nyochachara nyocha 20 dabere na ọgụgụ isi emere n'ime afọ 10 gara aga, naanị ọmụmụ na-enye 700 mg DHA ma ọ bụ karịa kwa ụbọchị gosipụtara nsonaazụ dị mma” (7).

Ụdị nnyefe ụfọdụ nwere ike ime ka mmanụ dị n'oké osimiri nwee ike ịmịkọrọ ya.Dịka ọmụmaatụ, Andrew Aussie, onye isi osote onye isi na onye isi ọrụ na Coromega, na-ekwu na ụlọ ọrụ ya bụ ọkachamara na, "emulsified omega-3 supplements na-enye 300% mma absorption."Dị ka ọmụmụ Raatz et al.nke Aussie kwuru, emulsification lipid na afọ bụ nzọụkwụ dị mkpa na mgbaze abụba "site na ọgbọ nke mmiri mmiri mmiri dị mkpa maka mmekọrịta dị n'etiti lipases mmiri na-adịghị ike" (8).Ya mere, site na emulsifying mmanụ azụ, a na-agafe usoro a, na-eme ka ọ dịkwuo mma (8).

Ihe ọzọ na-emetụta bioavailability bụ ụdị molekụla nke omega-3.Chris Oswald, DC, CNS, onye so na bọọdụ ndụmọdụ na Nordic Naturals, Watsonville, CA, kwenyere na triglyceride ụdị omega-3 dị irè karị n'ịkwalite ọkwa ọbara ọbara karịa ụdị sịntetik.E jiri ya tụnyere mkpụrụ ndụ ihe nke ethyl ester sịntetik, ụdị triglyceride sitere n'okike adịghị egbochi mgbaze enzymatic, na-eme ka ọ bụrụ 300% karịa nnabata (2).N'ihi nhazi molekụla ya nke acid fatty acid atọ jikọtara ya na ọkpụkpụ azụ glycerol, mgbe agbazere mmanụ azụ, ọdịnaya lipid ha na-agbanwe ka ọ bụrụ acid fatty nke nwere otu eriri.Mgbe etinyere ya na sel epithelial, a na-atụgharịghachi ha na triglycerides.Nke a ga-ekwe omume site na ọkpụkpụ azụ glycerol dị, nke ethyl ester agaghị enwe (2).

Ụlọ ọrụ ndị ọzọ kwenyere na phospholipid-bound omega-3 ga-eme ka mmịpụta dịkwuo mma.Cheryl Meyers, onye isi agụmakwụkwọ na ihe gbasara sayensị na EuroPharma, Inc., Greenbay, WI, na-ekwu na usoro a "ọ bụghị naanị na ọ na-arụ ọrụ dị ka usoro njem maka omega-3, kamakwa ọ na-enye nkwado ụbụrụ siri ike n'onwe ya."Myers na-akọwa otu mgbakwunye sitere na ụlọ ọrụ ya nke na-enye omega-3 nke nwere phospholipid nke ewepụtara na isi salmon (Vectomega).Ihe mgbakwunye ahụ nwekwara peptides nke o kwenyere na "nwere ike ichebe arịa ọbara dị nro na ụbụrụ site n'ịlụso mmebi oxidative ọgụ."

Maka ihe ndị yiri ya, ụfọdụ ụlọ ọrụ na-ahọrọ ịmepụta mmanụ krill, isi iyi ọzọ nke phospholipid-bound omega-3 nke na-enye ezigbo bioavailability n'ihi mmiri ha na-edozi.Lena Burri, onye isi ihe odide sayensị na Aker Biomarine Antarctic AS, Oslo, Norway, na-enye nkọwa ọzọ maka ihe kpatara ụdị DHA a ji dị oke mkpa: otu "DHA transporter (Mfsd2a, isi ngalaba nlekọta ezinụlọ nwere 2a)… na-anabata DHA naanị ma ọ bụrụ na ọ na-ejikọta na phospholipids-ka ọ bụrụ kpọmkwem lysoPC" (9).

Otu ọmụmụ ihe atụnyere nke krill, mmanụ sardine (ụdị triglyceride) na placebo na ebe nchekwa na-arụ ọrụ na ngụkọ na 45 ndị ​​okenye nọ na 61-72 maka izu 12.Site n'ịtụgharị mgbanwe nke mkpokọta oxyhemoglobin n'oge ọrụ, nsonaazụ gosipụtara mgbanwe dị ukwuu na ntinye uche na otu ọwa mgbe izu iri na abụọ gasịrị karịa placebo, na-atụ aro na mgbakwunye ogologo oge nke ma krill na mmanụ sardine "na-akwalite ọrụ ebe nchekwa na-arụ ọrụ site na ịgbalite cortex prefrontal dorsolateral na ndị agadi. ndị mmadụ, ma si otú ahụ na-egbochi mmebi na ọrụ ọgụgụ isi"(10).

Otú ọ dị, n'ihe gbasara ọrụ mgbako, mmanụ krill "gosipụtara nnukwu mgbanwe dị ukwuu na oxyhemoglobin dị n'akụkụ aka ekpe," ma e jiri ya tụnyere placebo na mmanụ sardine, nke na-egosighi mmetụta ọ bụla na-arụ ọrụ n'oge ọrụ mgbako (10).

Ndị ọzọ karịa inye aka na nnabata nke omega-3s, phospholipids na-arụ ọrụ dị mkpa na ahụike ọgụgụ isi na ikike nke aka ha.Dị ka Burri si kwuo, phospholipids na-eme ihe dị ka 60% nke ụbụrụ site n'ịdị arọ, karịsịa na dendrites na synapses.Na mgbakwunye na nke a, ọ na-ekwu na in vitro, uto irighiri akwara na-eme ka mmụba dị ukwuu maka phospholipids na uto akwara na-akpali ọgbọ phospholipid.A na-etinye mgbakwunye na phospholipids nke ukwuu ma dị irè n'ịkwado ọrụ ọgụgụ isi n'ihi na nhazi ha yiri nke dị na akpụkpọ ahụ akwara.

Phospholipids abụọ a na-ahụkarị bụ phosphatidylserine (PS) na phosphatidylcholine (PC).Shafat na-ekwu na PS enwetala nkwupụta ahụike tozuru oke nke nchịkwa nri na ọgwụ US (FDA) kwadoro.Nkwuputa ndị a gụnyere: "Iri PS nwere ike ibelata ihe ize ndụ nke ịda mbà n'obi na ndị agadi," "Iri PS nwere ike ibelata ihe ize ndụ nke dysfunction cognition na ndị agadi," na ruru eru, "Nchọpụta sayensị dị oke oke na nke mbụ na-egosi na PS nwere ike belata ihe ize ndụ. nke dementia / belata ihe ize ndụ nke adịghị arụ ọrụ nke uche na ndị agadi.FDA kwubiri na enwere ntakịrị ihe sayensị na-akwado nkwupụta a. "

Shafat na-akọwa na n'onwe ya, PS "dị irè ugbua na dose nke 100 mg / ụbọchị," nke dị ntakịrị karịa ụfọdụ ihe ndị ọzọ na-akwado nkwado.

N'ihe gbasara ọrụ ya, Chase Hagerman, onye nduzi akara na ChemiNutra, White Bear Lake, MN, na-ekwu na PS "na-enyere ndị na-edozi ahụ aka na-ahụ maka ọrụ akpụkpọ anụ na-etinye aka na nnyefe nke ozi mkpụrụ ndụ site na cell gaa na cell, na-enyere aka ịbanye n'ime sel, ma na-enyere aka. Ngwaahịa mkpofu metụtara nrụgide na-emerụ ahụ iji pụọ na cell.”

PC, n'aka nke ọzọ, dị ka nke a kpụrụ site na alpha-glyceryl phosphoryl choline (A-GPC), Hagerman na-ekwu, "na-akwaga na synaptic nerve endings nke dị n'ime dum Central ụjọ usoro, na n'aka na-abawanye njikọ na ntọhapụ nke. acetylcholine (AC)," nke bụ ihe dị mkpa neurotransmitter "nke dị ugbu a na ụbụrụ na anụ ahụ anụ ahụ," na-arụ ọrụ dị mkpa na "n'ụzọ bụ isi ọrụ ọ bụla na-achọpụta mgbe ọ dị na akwara, ọ na-etinye aka na nkwonkwo akwara."

Ihe dị iche iche na-arụ ọrụ na njedebe a.Dallas Clouatre, Ph.D., onye na-ahụ maka R&D na Jarrow Formulas, Inc., Los Angeles, CA, na-akọwa ha dị ka "ezinaụlọ nke otu mkpụrụ osisi," nke gụnyere uridine, choline, CDP-choline (Citocoline) na PC dị ka. akụkụ nke okirikiri ụbụrụ mgbe ụfọdụ a na-akpọ Kennedy Cycle.Ihe ndị a niile na-ekere òkè n'ịmepụta PC na ụbụrụ ma si otú ahụ na-emepụta AC.

Mmepụta AC bụkwa ihe ọzọ na-ebelata ka anyị na-aka.Otú ọ dị, n'ozuzu, n'ihi na neurons enweghị ike ịmepụta choline nke ha ma ga-anata ya n'ọbara, nri ndị na-enweghị choline na-emepụta ihe na-ezughị ezu nke AC (2).Enweghị choline dịnụ na-ekere òkè na mmepe nke ọrịa ndị dị ka Alzheimer na mbelata ọgụgụ isi metụtara afọ.Ọrụ nke onye nchọpụta Richard Wurtman, MD, si Massachusetts Institute of Technology tụrụ aro na n'ihi ezughị oke choline, ụbụrụ nwere ike n'ezie cannibalize PC si ya neural akpụkpọ anụ ime AC (2).

Neil E. Levin, CCN, DANLA, onye na-ahụ maka agụmakwụkwọ na-edozi ahụ na UGBUA Food, Bloomingdale, IL na-akọwa usoro "na-akwado nlezianya anya na mmụta site n'ịkwalite mmepụta AC kwesịrị ekwesị na ọrụ," site na ijikọta A-GPC, "ụdị choline bioavailable. , ” ya na Huperzine A iji kwado ọkwa AC (RememBRAIN sitere na nri UGBUA).Huperzine A na-ejigide AC site n'ịrụ ọrụ dị ka onye na-emechi ihe nke acetylcholinesterase, nke bụ enzyme nke na-akpata nkwụsị nke AC (11).

Dị ka Levy si kwuo, citicoline bụ otu n'ime ihe ọhụrụ ọhụrụ maka ịkwado cognition, na-elekwasị anya n'ihu lobe, nke bụ mpaghara maka idozi nsogbu, nlebara anya na itinye uche.Ọ na-ekwu na mgbakwunye na citicoline na ndị toro eto egosila "ime ka ncheta okwu dịkwuo mma, ịrụ ọrụ ncheta na cognition, ogologo oge nlebara anya, ọbara na-eruba n'ụbụrụ na ọrụ bioelectrical."Ọ na-ehota ọtụtụ ọmụmụ nke gosipụtara nsonaazụ dị mma, gụnyere nyocha abụọ nke kpuru ìsì, nke a na-achịkwaghị achịkwa, na-achịkwa ebebo nke ndị ọrịa 30 Alzheimer nke gosipụtara ọrụ ụbụrụ dị mma ma e jiri ya tụnyere placebo mgbe ọ na-ewere citicoline kwa ụbọchị, karịsịa n'etiti ndị nwere nkwarụ dị nro (12).

Elyse Lovett, onye njikwa ahịa na Kyowa USA, Inc., New York, NY, kwuru na ụlọ ọrụ ya nwere "naanị ụdị citicoline a na-amụ n'ụlọ ọgwụ na ndị okenye na ndị nọ n'afọ iri na ụma," nakwa na ọ bụ "naanị ụdị citicoline nwere GRAS [n'ozuzu ya." ghọtara dị ka nchekwa] ọnọdụ na United States" (Cognizin).

Ihe mgbakwunye ọzọ metụtara ya, dị ka Dan Lifton si kwuo, onye isi oche nke Maypro's Proprietary Branded Ingredients Group, Purchase, NY, bụ INM-176 sitere na mgbọrọgwụ Angelica gigas Nakai, bụ nke egosiri na-akwado ahụike ahụike site na ịba ụba ụbụrụ AC.

Enweghị ụkọ vitamin na-egosipụtakarị onwe ha site na mbelata ọrụ ọgụgụ isi.Enweghị vitamin B12, dịka ọmụmaatụ, nwere ike ịgụnye mgbaàmà dịka mgbagwoju anya, nkwụsị ncheta, mgbanwe mmadụ, paranoia, ịda mbà n'obi na àgwà ndị ọzọ yiri mgbaka.Ọbụghị naanị nke ahụ, mana 15% nke ndị agadi yana ihe ruru 40% nke ndị nwere akara ngosi karịa afọ 60 nwere ọkwa B12 dị ala ma ọ bụ oke (13).

Dị ka Mohajeri et al., B12 na-arụ ọrụ dị mkpa n'ịgbanwe homocysteine ​​​​(Hcy) n'ime amino acid methionine, ma vitamin B ndị ọzọ folate (B9) na B6 bụ ihe dị mkpa na-akwado maka metabolization na-eme, na-enweghị ya, Hcy na-agbakọta.Hcy bụ amino acid a na-emepụta n'ime ahụ site na methionine nri ma dị mkpa maka ọrụ cellular nkịtị, mana nnukwu mkpokọta ya na-emebi ọrụ ahụ kwuru (14)."Egosipụta ọkwa ọbara dị elu nke homocysteine ​​​​na-emebi ebe nchekwa na ọtụtụ akụkụ ndị ọzọ nke ọrụ ọgụgụ isi," ka Michael Mooney, onye nduzi sayensị na agụmakwụkwọ na SuperNutrition, Oakland, CA na-ekwu.

Mohajeri et al.na-akwado nkwupụta a: “E jikọtara ịdị njọ nke enweghị ọgụgụ isi na mmụba nke plasma Hcy.Ọzọkwa, a kọrọ nnukwu ihe ize ndụ nke ọrịa Alzheimer mgbe ọkwa folate na B12 dị ala” (15).

Niacin bụ vitamin B ọzọ na-akwado ọrụ nchekwa na ọgụgụ isi.Dị ka Mooney si kwuo, niacin, ụdị vitamin B3 na-arụsi ọrụ ike, bụ ndị dọkịta na-enyekarị ya na 1,000 mg ma ọ bụ karịa kwa ụbọchị iji kwado ọkwa cholesterol nkịtị, mana nchọpụta a na-achịkwa placebo chọpụtara na dose 425 mg nke nri kwa ụbọchị na-eme ka nchekwa dịkwuo mma. nwalee akara site na ihe ruru 40% yana imeziwanye ndekọ ndekọ uche site na ihe ruru 40%.N'ebe ike dị elu, a na-egosikwa niacin na-eme ka ọbara na-erugharị n'ụbụrụ, "nke na-eme ka mgbasa nke nri na ikuku oxygen dị n'ụbụrụ," ka ọ gbakwụnyere (16).

Na mgbakwunye na niacin, Mooney na-akọwa niacinamide, nke bụ ụdị vitamin B3 ọzọ.Na 3,000 mg / ụbọchị, UC Irvine na-amụ niacinamide dị ka ọgwụgwọ nwere ike ịgwọ ọrịa Alzheimer na ọnwụ ebe nchekwa jikọtara ya na nsonaazụ dị mma na nyocha òké.Ụdị abụọ a, ọ kọwara, na-atụgharị n'ime ahụ n'ime NAD +, molecule nke egosiri na ọ na-agbanwe ịka nká na mitochondria, onye na-emepụta ike cellular dị mkpa.Ọ na-ekwu, "Nke a nwere ike bụrụ nnukwu ihe na-enye aka na nchekwa nchekwa vitamin B3 na mmetụta ndị ọzọ na-egbochi ịka nká," ka o kwuru.

Ihe mgbakwunye ọzọ iji kwado ndị ahịa bụ PQQ.Clouatre na-ekwu na ụfọdụ ndị na-ewere ya dị ka nanị vitamin ọhụrụ a chọtara n'ime iri afọ ole na ole gara aga, na-egosi ihe ndị dị mma n'akụkụ ndị dị ka ihe nchebe akwara ozi."PQQ na-egbochi oke ọgbọ nke ọtụtụ radicals, gụnyere oke peroxynitrite radical," ka ọ na-ekwu, na PQQ egosila mmetụta dị mma na mmụta na ebe nchekwa na ọmụmụ anụmanụ na ụmụ mmadụ.Otu nnwale ụlọ ọgwụ chọpụtara na nchikota nke 20 mg nke PQQ na CoQ10 nyere uru dị ukwuu na isiokwu mmadụ na ebe nchekwa, nlebara anya na cognition (17).

Lifton na-ekwu dị ka niacin, PQQ na CoQ10 na-akwado ọrụ mitochondrial.Ọ na-ekwu na CoQ10 na-eme nke a site n'ichebe "mitochondria kpọmkwem site na mmebi n'ihi mmegide na-aga n'ihu na-aga n'ihu," yana ịba ụba "mmepụta ume cell, nke nwere ike ime ka ike dịkwuo maka usoro ọgụgụ isi."Nke a dị mkpa n'ihi na "nchọpụta ọhụrụ na-akpali akpali na-egosi na otu n'ime isi ihe na-akpata nsogbu ncheta dị nro na-ejikọta na ịka nká bụ mmebi nke mitochondria anyị," ka Lifton na-ekwu.

Magnesium bụ ihe dị mkpa ịnweta maka ịnọgide na-arụ ọrụ nke ọma, ma ọ bụ maka nke ahụ, ọrụ ahụ n'ozuzu ya.Dị ka Carolyn Dean, MD, ND si kwuo, onye otu ndụmọdụ ahụike ahụike nke Òtù Na-ahụ Maka Nri na-edozi ahụ, "Magnesium naanị chọrọ na 700-800 usoro enzyme dị iche iche" na "ATP (adenosine triphosphate) mmepụta na okirikiri Krebs na-adabere na magnesium maka isii. nke nzọụkwụ asatọ ya.”

N'ihu ọgụgụ isi, Dean na-ekwu na magnesium na-egbochi neuro-mbufụt nke nkwụnye ego nke calcium na ọla ndị ọzọ dị arọ na ụbụrụ ụbụrụ yana ichebe ọwa ion na igbochi ọla ndị dị arọ ịbanye.Ọ na-akọwa na mgbe magnesium dị ala, calcium na-agbaba na-akpata ọnwụ cell.Levin na-agbakwụnye, "Nnyocha ndị na-adịbeghị anya egosila na ọ dịkwa oke mkpa maka ahụike ụbụrụ nkịtị na ọrụ ụbụrụ nkịtị site n'ịkwado njupụta na nkwụsi ike nke synapses neuronal."

N'akwụkwọ ya bụ Magnesium Miracle, Dean na-akọwa na erughị eru na magnesium naanị nwere ike ịmepụta mgbaàmà nke ịda mbà n'obi.Nke a bụ eziokwu karịsịa ka anyị na-aka nká, ebe ọ bụ na ike ahụ nwere ike ịnweta magnesium site na nri anyị na-ebelata ma ọgwụ ndị na-emekarị na ndị agadi nwere ike igbochi ya (18).Ya mere, ọkwa magnesium n'ime ọbara nwere ike ibelata n'ihi na ahụ enweghị ike ịmịnye mineral, nri na-adịghị mma na ọgwụ, na-emepụta oke calcium na glutamate (karịsịa ma ọ bụrụ na-eri nri dị elu na MSG), ha abụọ nwere ọrụ ha ga-egwu. na-adịghị ala ala neural degeneration na mmepe nke dementia (19).

Ọ bụ ezie na nri ndị na-edozi ahụ dị oke mkpa maka ịnọgide na-arụ ọrụ ọgụgụ isi dị mma, ihe enyemaka herbal nwekwara ike inye nkwado ọzọ n'ọtụtụ dị iche iche.Enwere ike ịmepụta mbelata ọgụgụ isi na mgbaka afọ n'ụzọ dị iche iche, na mbelata ọbara ọbara nke ụbụrụ bụ otu n'ime usoro dị iche iche.Ọtụtụ herbs na-arụ ọrụ iji lụso ihe a ọgụ.Ekwesiri ighota na mkpuru osisi nke na-eme ka mgbasa ọbara ka mma nwere ike di ize ndụ nye ndi ahia bu ndi na-añụrị ọgwụ na-ebelata ọbara dị ka warfarin.

Ọrụ bụ isi nke Gingko biloba bụ mmụba ọbara nke ụbụrụ ụbụrụ, nke na-ekere òkè dị ukwuu na mmepe nke dementia ma ọ bụ ọrịa Alzheimer ma ọ bụ ọrịa cerebrovascular malitere.A na-ekwukwa na ọ na-eweghachi ọrụ mitochondrial na-adịghị mma iji melite ike nke neuronal, mee ka choline na-enweta na hippocampus, na-egbochi nchịkọta na nsị nke protein b-amyloid ma nwee mmetụta antioxidant (20, 21).

Levy na-ekwu maka ọmụmụ ihe pilot nke izu anọ na Neuroradiology nke "kpughere mmụba pasent anọ ruo asaa na ọbara ụbụrụ na oke nke 120 mg kwa ụbọchị" nke gingko (22).Ọmụmụ ihe dị iche iche, nke a na-achịkwa ebebo, nke kpuru ìsì abụọ na-ekpebi ịdị irè na nchekwa nke gingko biloba na ndị ọrịa nwere nkwarụ dị nro na mgbaàmà neuropsychiatric (NPS) nke Gavrilova et al., chọpụtara na "n'oge usoro ọgwụgwọ 24-izu, mmụba na NPS na ikike ọgụgụ isi dị ịrịba ama ma na-apụtakarị na ndị ọrịa na-ewere 240 mg kwa ụbọchị nke G. biloba wepụ EGb 761 karịa ndị ọrịa na-ewere placebo" (23).

A na-anwale ịdị irè nke gingko biloba na ọnọdụ ndị ọzọ dị ka nsogbu nlebara anya hyperactive (ADHD) na ụmụaka.Otu nyocha nwere oke mana na-ekwe nkwa nke Sandersleben et al.kọrọ na mgbe emejuchara ya na gingko, a chọtara mmụba dị ukwuu maka ntule ndị nne na nna na-eleba anya nke ụmụ ha… hyperactivity, impulsivity, and the total scores of the sympatibility agbadala nke ukwuu,” na, “Mmalite dị ịrịba ama gbasara Prosocial Behavior” (24) .N'ihi njedebe nke ọmụmụ ihe, dị ka enweghị njikwa ma ọ bụ ihe nlele ka ukwuu, ọ nweghị nkwubi okwu siri ike nwere ike ịbịaru na ịdị irè ya, ma na-atụ anya na ọ ga-agba ume ka ọ gbasie ike n'ụzọ zuru ezu na-achịkwa ule.

Osisi ọzọ na-arụ ọrụ n'otu aka ahụ bụ Bacopa monniera nke, dị ka Levy si kwuo, nchọpụta anụmanụ na nso nso a na Phytotherapy Research gosiri "25% mmụba nke ọbara na-eruba na ụbụrụ n'etiti ụmụ anụmanụ na-ewere 60 mg nke bacopa monniera kwa ụbọchị ma e jiri ya tụnyere enweghị mmụba na ndị nyere donepezil. (25).

A na-ekwukwa na ọ nwere mmetụta antioxidant.Dị ka Shaheen Majeed si kwuo, onye isi ahịa nke Sabinsa Corp., East Windsor, NJ, bacopa "na-egbochi peroxidation lipid ma si otú a na-egbochi mmebi nke neurons cortical."Lipid peroxidation na-eme n'oge nrụgide oxidative jikọtara ya na ụkọ DHA, nke, ọzọ, bụ ihe mgbaàmà nke Alzheimer.

Mary Rove, ND, onye nkuzi ahụike na Gaia Herb, Brevard, NC, kwukwara na iji herbs dị ka pepemint na rosemary na-agbakwunye Gingko ha.Dị ka ya si kwuo, pepemint na-akwado ịmụrụ anya na "nnyocha abanyela na rosmaranic acid, ihe na-arụ ọrụ nke nwere ihe ndị na-eme ka ahụ dị mma."Ọ tụgharịrị, ọ gbakwụnyere, “enwere ọtụtụ data ọgbara ọhụrụ iji jide obere okwu ahụ bụ́ 'rosemary maka ncheta.'”

Huperzine A, nke a kpọtụrụ aha na mbụ maka ọrụ ya dị ka acetylcholinesterase inhibitor, sitere na ahịhịa ndị China Huperzia serrata.Ikike ya iji gbochie nkwụsị nke acetylcholine yiri nke ọgwụ FDA kwadoro iji gwọọ mgbaàmà nke ọrịa Alzheimer gụnyere donepezil, galantamine na rivastigmine, nke bụ cholinesterase inhibitors (11).

Meta-analysis nke Yang et al.kwubiri, "Huperzine A yiri ka ọ nwere mmetụta bara uru na mmelite nke ọrụ ọgụgụ isi, ọrụ ndụ kwa ụbọchị na nyocha ụlọ ọgwụ zuru ụwa ọnụ na ndị sonyere na ọrịa Alzheimer."Ha dọrọ aka ná ntị, ka ọ dị, na e kwesịrị iji nlezianya tụgharịa nchoputa n'ihi usoro adịghị mma nke ule ndị agụnyere, ma kpọkuo maka nnwale ndị ọzọ siri ike (11).

Antioxidants.Ọtụtụ n'ime ihe mgbakwunye a tụlere nwere ikike antioxidant, nke na-enyere aka mee ka ha dị irè megide mmejọ ọgụgụ isi, nke nrụgide oxidative na-enyekarị aka.Dị ka Meyers si kwuo, "N'ihe fọrọ nke nta ka ọ bụrụ ọrịa niile dị n'ụbụrụ, mbufụt bụ ihe dị mkpa - ọ na-agbanwe ọdịdị nke otu mkpụrụ ndụ na-esi emekọrịta ihe."Ọ bụ ya mere e ji nwee mmụba dị otú ahụ na-ewu ewu na nyocha n'ime curcumin, nke bụ ihe a na-enweta site na turmeric, nke gosipụtara iji belata mkpali na mmebi oxidative na ụbụrụ ma na-akwado ịkụnye neurons kwesịrị ekwesị, ka Meyers na-ekwu.

N'ihe banyere ọnọdụ ndị dị ka Alzheimer's, curcumin nwere ike ịkpaghasị mwube nke beta-amyloid.Otu nnyocha nke Zhang et al., bụ onye nwalere curcumin na omenala cell na mouse primary cortical neurons, chọpụtara na ogwu ahụ belatara ọkwa beta-amyloid site na ibelata maturation nke amyloid-beta precursor protein (APP).Ọ mebiri APP maturation site n'otu oge na-abawanye nkwụsi ike nke APP akabeghị aka na ibelata nkwụsi ike nke APP tozuru okè (26).

Achọrọ nyocha ọzọ iji ghọta nke ọma ụdị mmetụta curcumin nwere ike inwe na cognition yana otu ọ ga-esi meziwanye mmejọ ọgụgụ isi.Ugbu a, McCusker Alzheimer's Research Foundation na-akwado nyocha a na-eme na Mahadum Edith Cowan dị na Perth, Australia, iji nwalee ịdị irè nke curcumin na ndị ọrịa nwere obere nghọta.Ọmụmụ ihe nke ọnwa iri na abụọ ga-enyocha ma ahịhịa ahụ ọ ga-echekwa ọrụ ọgụgụ isi nke ndị ọrịa.

Ihe ọzọ antioxidant siri ike na-akwado ọrụ ọgụgụ isi bụ Pycnogenol (nke Horphag Research kesara).E wezụga ịbụ ike dị ukwuu megide mmebi oxidative, ahịhịa ahụ, nke sitere na ogbugbo pine pine nke France, egosikwara na ọ na-eme ka mgbasa ọbara dịkwuo mma, gụnyere microcirculation na ụbụrụ yana ịbawanye mmepụta nke nitric oxide, nke na-arụ ọrụ dị ka neurotransmitter. , ikekwe na-enye aka n'ichekwa ihe na ikike mmụta (25).N'ime otu ọmụmụ ihe nke were izu asatọ, ndị nchọpụta nyere ụmụ akwụkwọ 53 sitere na afọ 18 ruo 27 Pycnogenol ma nyochaa arụmọrụ ha na ule n'ezie.Nsonaazụ gosiri na otu nnwale ahụ dara ule ole na ole karịa njikwa (asaa vs. itoolu) wee mee 7.6% ka mma karịa njikwa (27).WF

1. Joseph C. Maroon na Jeffrey Bost, Mmanụ azụ: The Natural Anti-Inflammatory.Basic Health Publications, Inc. Laguna Beach, California.2006. 2. Michael A. Schmidt, Brian-Building Nutrition: Olee otú abụba na mmanụ na-eri nri si emetụta uche, anụ ahụ, na mmetụta mmetụta uche, mbipụta nke atọ.Akwụkwọ Frog, Ltd. Berkeley, California, 2007. 3. J. Thomas et al., "Omega-3 fatty ccids na mmalite mgbochi nke ọrịa neurodegenerative mkpali: A na-elekwasị anya na ọrịa Alzheimer."Hindawa Publishing Corporation, BioMed Research International, Mpịakọta 2015, Nkeji edemede ID 172801. 4. K. Yurko-Mauro et al., "Mmetụta bara uru nke docosahexaenoic acid na cognition na afọ-mmetụta uche ọdịda."Alzheimers Dement.6 (6): 456-64 .2010. 5. W. Stonehouse et al., "Mgbakwunye DHA kwalitere ma ebe nchekwa na oge mmeghachi omume na ndị na-eto eto nwere ahụike: nnwale a na-achịkwa nke na-enweghị usoro."Aha m bụ J Clin Nutr.97: 1134-43 .2013. 6. EY Chew et al., "Mmetụta nke omega-3 fatty acids, lutein/zeaxanthin, ma ọ bụ ihe mgbakwunye nri ndị ọzọ na ọrụ ọgụgụ isi: AREDS2 na-anwale ụlọ ọgwụ."JAMA.314 (8): 791-801.2015. 7. Adam Ismail, "Omega-3s na cognition: usoro onunu ogwu."http://www.goedomega3.com/index.php/blog/2015/08/omega-3s-and-cognition-dosage-matters.8. Susan K. Raatz et al., "Enwetara nnabata nke omega-3 fatty acids sitere na emulsified ma e jiri ya tụnyere mmanụ azụ̀ kpuchiri ekpuchi."J Am Diet Assoc.109 (6).1076-1081.2009. 9. LN Nguyen et al., "Mfsd2a bụ onye na-ebufe maka omega-3 fatty acid docosahexaenoic acid dị mkpa."http://www.nature.com/nature/journal/v509/n7501/full/nature13241.html 10. C. Konagai et al., "Mmetụta nke mmanụ krill nwere n-3 polyunsaturated fatty acids n'ụdị phospholipid na ụbụrụ mmadụ ọrụ: nnwale a na-achịkwaghị achịkwa n'ime ndị ọrụ afọ ofufo agadi ahụike siri ike. "Clin Interv ịka nká.8: 1247-1257.2013. 11. Guoyan Yang et al., "Huperzine A maka ọrịa Alzheimer: nyochaa usoro na meta-analysis nke randomized ụlọ ọgwụ ọnwụnwa."PLoS ONE.8 (9).2013. 12. XA.Alvarez et al."Ọmụmụ ihe na-achịkwa placebo okpukpu abụọ na citicoline na APOE genotyped Alzheimer's ọrịa ndị ọrịa: mmetụta na arụmọrụ cognitive, ụbụrụ bioelectrical ọrụ na ụbụrụ perfusion."Ụzọ Chọta Exp Clin Pharmacol.21 (9): 633-44 .1999. 13. Sally M. Pacholok na Jeffrey J. Stuart.Ọ nwere ike ịbụ B12: Ọrịa na-efe efe nke nyocha, mbipụta nke abụọ.Akwụkwọ ndị ọkwọ ụgbọala Quill.Fresno, CA.2011. 14. M. Hasan Mohajeri et al., "Enweghi oke vitamin na DHA na ndị agadi: Mmetụta maka ịka nká ụbụrụ na ụdị nkwarụ Alzheimer."Nri nri.31: 261-75 .2015. 15. SM.Loriaux et al.“Mmetụta nke nicotinic acid na xanthinol nicotinate na ebe nchekwa mmadụ n'ụdị afọ dị iche iche.Ọmụmụ kpuru ìsì abụọ.”Psychopharmacology (Berl).867 (4): 390-5 .1985. 16. Steven Schreiber, "Ọmụmụ Nchekwa nke Nicotinamide iji gwọọ ọrịa Alzheimer."https://clinicaltrials.gov/ct2/show/NCT00580931?term=nicotinamide+alzheimer%27s&rank=1.17. Koikeda T. et.al, "Pyrroloquinoline quinone disodium nnu mere ka ọrụ ụbụrụ dị elu dịkwuo elu."Ndụmọdụ ahụike na ọgwụgwọ ọhụrụ.48 (5): 519. 2011. 18. Carolyn Dean, The Magnesium Ebube.Akwụkwọ Ballantine, New York, NY.2007. 19. Dehua Chui et al., "Magnesium na ọrịa Alzheimer."Magnesium na Central Nevous System.Mahadum Adelaide Press.2011. 20. S. Gauthier na S. Schlaefke, "Irụ ọrụ na nnabata nke Gingko biloba wepụ Egb 761 na dementia: nyocha nhazi na meta-analysis nke ule ndị a na-achịkwa ebebo."Ihe mgbochi ụlọ ọgwụ na ịka nká.9: 2065-2077.2014. 21. T. Varteresian na H. Lavretsky, "Ngwaahịa eke na ihe mgbakwunye maka ịda mbà n'obi geriatric na nsogbu uche: nyocha nke nyocha.Curr Psychiatry Rep. 6 (8), 456. 2014. 22. A. Mashayekh, et al., "Mmetụta nke Ginkgo biloba na ọbara ọbara ụbụrụ nke a na-enyocha site na ọnụọgụ MR perfusion imaging: nchọpụta pilot."Neuroradiology.53 (3): 185-91 .2011. 23. SI Gavrilova, et al., "Irụ ọrụ na nchekwa nke Gingko biloba wepụ EGb 761 na nhụsianya dị nro na mgbaàmà neuropsychiatric: ihe a na-ahụ anya, nke a na-achịkwa ebebo, kpuru ìsì abụọ, ikpe multicenter."Int J Geriatr Psychiatry.29:1087-1095.2014. 24. HU Sandersleben et al., "Gingko biloba wepụ EGb 761 na ụmụaka nwere ADHD."Z. Kinder-Jugendpsychiatr.Psychother.42 (5): 337-347 .2014. 25. N. Kamkaew, et al., "Bacopa monnieri na-eme ka ọbara ọbara na-eru n'ọbara na oke oke nke ọbara mgbali."Phytother Res.27 (1): 135-8 .2013. 26. C. Zhang, et al., "Curcumin na-ebelata ọkwa amyloid-beta peptide site na ibelata maturation nke amyloid-beta precursor protein."J Biol Chem.285 (37): 28472-28480.2010. 27. Richard A. Passwater, Ntuziaka onye ọrụ na mgbakwunye Pynogenol Nature's Most Versatile Supplement.Basic Health Publications, Laguna Beach, CA.2005. 28. R. Lurri, et al., "Mgbakwunye Pynogenol na-eme ka ọrụ ọgụgụ isi, nlebara anya na ịrụ ọrụ nke uche na ụmụ akwụkwọ."J Neurosurg Sci.58 (4): 239-48 .2014.

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Magazin WholeFoods bụ ebe nkwụsị gị maka akụkọ ahụike na nri nri ugbu a, gụnyere ụdị ndụ na-enweghị gluten na akụkọ mgbakwunye nri.

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